Objective: To explore the therapeutic effect and safety of Yishen Tongluo Fang in treatment of chronic prostatitis cause by kidney deficiency blood stasis. Method: A total of 240 eligible cases were randomly divided into the traditional Chinese medicine (TCM) group

the western medicine (WM) group and the TCM and WM group

with 80 cases in each group. The TCM group was treated with Yishen Tongluo Fang; the WM group was given prostat tablets; the TCM and WM group was provided with Yishen Tongluo Fang combined with prostat tablets

with a course of 2 months. The clinical symptoms

serum inflammatory factors

hemorheological indexes and prostatic fluid indexes in three groups were observed before and after treatment. The total effective rate was recorded

and the 6-month follow-up visits were paid to observe the recurrence rate and the adverse reactions. Result: Seven cases were shed during the study. The total effective rate was 97.5% in the TCM and WM group

which was higher than 87.2% in the TCM group and 84.2% in the WM group (P<0.05). The total effective rate in the TCM was higher than that in the WM group

without statistically significant difference. After treatment

the serum inflammatory factors

hemorheological indexes and prostatic fluid indexes in the TCM and WM group were higher than those in the WM group and the TCM group. There was no significant difference between the TCM group and the WM group. By the adverse reactions

the order from low to high was the TCM group (1.3%) < the TCM and WM group (6.3%) < the WM group (17.1%) (P<0.05). Conclusion: Yishen Tongluo Fang is safe and effective in the treatment of chronic prostatitis cause by kidney deficiency blood stasis. Its combination with prostat tablets has a synergistic effect and detoxification.