Effect of Gualou Honghua Gancao Tang on Inflammatory Factors and T Lymphocyte Subsets in Herpes Zoster with Stagnated Heat of Liver Meridian

YU Zhi-ren; GU Yong-ge; GUO Xin; ZHAO Yan-xia; ZHANG Li-tao

doi:10.13422/j.cnki.syfjx.20181927

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Effect of Gualou Honghua Gancao Tang on Inflammatory Factors and T Lymphocyte Subsets in Herpes Zoster with Stagnated Heat of Liver Meridian

更新时间：2024-09-23

- Effect of Gualou Honghua Gancao Tang on Inflammatory Factors and T Lymphocyte Subsets in Herpes Zoster with Stagnated Heat of Liver Meridian
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 22, Pages: 159-163(2018)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.20181927
  CLC： R275.9
- Published：2018
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YU Zhi-ren, GU Yong-ge, GUO Xin, et al. Effect of Gualou Honghua Gancao Tang on Inflammatory Factors and T Lymphocyte Subsets in Herpes Zoster with Stagnated Heat of Liver Meridian[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(22): 159-163.
DOI：

YU Zhi-ren, GU Yong-ge, GUO Xin, et al. Effect of Gualou Honghua Gancao Tang on Inflammatory Factors and T Lymphocyte Subsets in Herpes Zoster with Stagnated Heat of Liver Meridian[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(22): 159-163. DOI： 10.13422/j.cnki.syfjx.20181927.

摘要

目的：探讨瓜蒌红花甘草汤治疗肝经郁热型带状疱疹患者的临床疗效及对炎症因子和T淋巴细胞亚群的影响。方法：选取本院皮肤科就诊的肝经郁热型带状疱疹患者162例，按照随机数字表法将患者分为对照组和治疗组，对照组采用常规治疗口服阿昔洛韦片和甲钴胺胶囊，治疗组在对照组的基础上给予瓜蒌红花甘草汤治疗，治疗两周后，观察患者临床疗效并检测治疗前后炎症因子和T淋巴细胞亚群水平的变化情况。随访6个月，观察患者后遗神经痛（PHN）的发生情况。结果：治疗后，治疗组临床有效率明显高于对照组（P<0.05）。治疗组患者止疱时间、结痂时间、脱痂时间、疼痛缓解时间均明显短于对照组（P<0.05）。治疗第7，14天时患者疼痛视觉模拟评分（VAS）明显低于本组治疗前（P<0.05），且治疗组明显低于对照组（P<0.05）。随访6个月，治疗组患者PHN发生率低于对照组（P<0.05）。治疗后，治疗组患者血清白细胞介素（IL）-4，IL-6，肿瘤坏死因子（TNF）-α和CD8+水平较本组治疗前降低，且低于对照组（P<0.05）；而CD4+和CD4+/CD8+水平较本组治疗前升高，且高于对照组（P<0.05）。结论：瓜蒌红花甘草汤通过增强肝经郁热型带状疱疹患者免疫功能及抑制炎症反应，来减轻患者疼痛，从而提高临床疗效。

Abstract

Objective:To investigate the effect of Gualou Honghua Gancao Tang on inflammatory factors and T lymphocyte subsets in herpes zoster with stagnated heat of the liver meridian. Method:A total of 162 cases in our hospital were divided into control group and treatment group by random number table method. The control group was treated with oral aciclovir tables and mecobalamin capsules

and treatment group was given Gualou Honghua Gancao Tang in addition to the therapy of control group for two week. The clinical effect and inflammatory factors and T lymphocyte subsets levels were observed. After 6 months of follow-up

postherpetic neuralgia (PHN) incidence was recorded. Result:After treatment

the clinical effective rate of treatment group was significantly higher than that of control group (P < 0.05). The blister time

scab time

scab removal time and pain relief time in treatment group were significantly shorter than those of control group (P<0.05). The visual analogue scale (VAS) score at 7

14 d after treatment was significantly lower than that before treatment (P<0.05)

and the treatment group was significantly lower than that of control group (P<0.05). After 6 months of follow-up

the incidence of PHN in treatment group was lower than that in control group (P<0.05). After treatment

the interleukins (IL-4)

IL-6

tumor necrosis factor (TNF)-α and CD8+ levels in treatment group were decreased and significantly lower than those of control group (P<0.05)

while the CD4+ and CD4+/CD8+ levels were increased compared with before treatment and significantly higher than those of control group (P<0.05). Conclusion:Gualou Honghua Gancao Tang could improve the clinical efficacy of herpes zoster patients with stagnated heat of the liver meridian by enhancing the immune function and inhibiting the inflammatory reaction.

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