Effect of Autophagy and Chinese Medicine Regulating Autophagy in Treatment and Prevention of Diseases

LI Huan; MIAO Ming-san

doi:10.13422/j.cnki.syfjx.20181936

您当前的位置：

首页 >

文章列表页 >

Effect of Autophagy and Chinese Medicine Regulating Autophagy in Treatment and Prevention of Diseases

更新时间：2024-01-04

- Effect of Autophagy and Chinese Medicine Regulating Autophagy in Treatment and Prevention of Diseases
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 20, Pages: 200-207(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20181936
  CLC： R285
- Published：2018
- 稿件说明：
移动端阅览
LI Huan, MIAO Ming-san. Effect of Autophagy and Chinese Medicine Regulating Autophagy in Treatment and Prevention of Diseases[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(20): 200-207.
DOI：

LI Huan, MIAO Ming-san. Effect of Autophagy and Chinese Medicine Regulating Autophagy in Treatment and Prevention of Diseases[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(20): 200-207. DOI： 10.13422/j.cnki.syfjx.20181936.

摘要

自噬是广泛存在于真核细胞中的生命现象，维持细胞内的稳态及胞内成分的不断更新，在保持细胞正常的生理状态过程中起着至关重要的调节作用。其是一条依赖溶酶体降解的途径，它具有清除细胞内蛋白质聚集体、损伤的细胞器，维持细胞内稳态的作用，同时还参与细胞很多生理和病理过程，尤其与肿瘤和神经退行性疾病的发生发展密切相关。近年来，中药单体通过调控自噬的某些信号通路，影响和抑制肿瘤的发生发展的作用机制日渐明了；此外，中医药在防治老年神经退行性疾病理论知识方面也取得了很多突破；本文介绍了与自噬密切相关的信号通路如雷帕霉素靶向蛋白信号通路（mTOR），磷脂酰肌醇-3-激酶/蛋白激酶B （PI3K/Akt）信号转导通路，活性氧（ROS）信号通路，核转录因子-κB （NF-κB）信号通路，另外还从中药单体调节自噬机制方面，概述中药单体在肿瘤和神经退行性疾病治疗中的应用及其分子机制。诸多研究表明，中药单体通过激活自噬途径，调节自噬活性，在肿瘤治疗和防治老年病如帕金森、阿尔兹海默症、亨廷顿等疾病方面有很好的改善作用，研究中药单体对肿瘤和神经退行性疾病的防治是崭新的思路和方法，以期为中医药研究工作者在探索中医药调控自噬的作用靶点研究中提供基础理论支撑，发现更多的中药及单体化合物通过调节自噬用于治疗肿瘤、神经退行性疾病等多种疾病。

Abstract

Autophagy is a widespread phenomenon in eukaryotic cells

with the aim to maintain the intracellular homeostasis and the constant update of intracellular components

and play a crucial regulatory role in maintaining the normal physiological state of cells. It is a way to degradate by relying on lysosomal

has organelles for clearing intracellular protein aggregates and damages

and maintains intracellular homeostasis. At the same time

it is also involved in many physiological and pathological processes of cells

especially closely related to the occurrence and development of tumors and neurodegenerative diseases. In recent years

traditional Chinese medicine(TCM)monomers have been found to have mechanisms for impacting and inhibiting the occurrence and development of tumor through the regulation of some signaling pathways of autophagy; In addition

TCM has many breakthroughs in the theoretical knowledge of prevention and treatment of neurodegenerative diseases. This article describes the signal pathways closely related to autophagy

such as rapamycin-targeted protein signaling (mTOR)

phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway (PI3K/Akt)

reactive oxygen species signaling (ROS) and nuclear factor (NF)-κB. In addition

it also summarizes the effect of TCM monomers in the treatment of tumor and neurodegenerative diseases by regulating autophagy mechanism and its molecular mechanism of action. Many studies have shown that TCM monomers can improve autophagy via autophagy pathway and play an important role in treatment and prevention of tumor and diseases

such as Parkinson's disease

Alzheimer's disease and Huntington disease. The study of the effect of TCM monomers in the prevention and treatment of cancer and neurodegenerative diseases provides new ideas and methods

in the expectation of providing basic theoretical support for TCM medicine research workers in exploring the role of TCM in the regulation of autophagy

and find more TCM and its monomeric compounds through the regulation of autophagy for the treatment of tumors

neurodegenerative diseases and other diseases.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Improved Learning and Memory in Sleep-deprived Mice by Anmeidan via Cellular Autophagy Regulation Through PI3K/Akt/mTOR Signaling Pathway

Effect of Yishen Huayu Prescription on Autophagy of Transdifferentiated TCMK-1 Cells Based on SIRT1/FoxO1 Pathway

Ginsenoside Rg₂ Protects Heart After Acute Myocardial Infarction by Regulating PI3K/Akt/mTOR Signaling Pathway

Effect of Guiqi Yiyuan Ointment on Lewis Lung Cancer Mice by Increasing Autophagic Flux and Stabilizing PD-L1 Expression Through Regulation of ERK Signaling Pathway

Mitochondrial Quality Control Regulating Pathogenesis of Sarcopenia and Its Intervention by Traditional Chinese Medicine： A Review

Related Author

LIU Huizhen

ZHANG Yini

CHEN Yumeng

XIAO Chunfeng

ZHANG Xuesong

WANG Ping

LI Qingru

ZHANG Linqi

Related Institution

School of Traditional Chinese Medicine， Hubei University of Chinese Medicine

Engineering Research Center of Traditional Chinese Medicine Protection Technology and New Product Development for the Elderly Brain Health， Ministry of Education， Hubei University of Chinese Medicine

School of Basic Medical Sciences， Hubei University of Chinese Medicine

School of Pharmaceutics， Hubei University of Chinese Medicine

Hubei Shizhen Laboratory

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰