Effect of Modified Chaihu Shugan Tang in Treatment of Liver-Qi Stagnation Type of Post-stroke Depression and on Serum Nerve Transmitters and Nerve Function Recovery

SHI Juan-Juan; YUAN Zhuo; SHEN Li; LI Hong-na; ZHANG Jia-rui

doi:10.13422/j.cnki.syfjx.20182029

您当前的位置：

首页 >

文章列表页 >

Effect of Modified Chaihu Shugan Tang in Treatment of Liver-Qi Stagnation Type of Post-stroke Depression and on Serum Nerve Transmitters and Nerve Function Recovery

更新时间：2024-09-23

- Effect of Modified Chaihu Shugan Tang in Treatment of Liver-Qi Stagnation Type of Post-stroke Depression and on Serum Nerve Transmitters and Nerve Function Recovery
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 24, Issue 21, Pages: 188-192(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20182029
  CLC： R277.7
- Published：2018
- 稿件说明：
移动端阅览
SHI Juan-Juan, YUAN Zhuo, SHEN Li, et al. Effect of Modified Chaihu Shugan Tang in Treatment of Liver-Qi Stagnation Type of Post-stroke Depression and on Serum Nerve Transmitters and Nerve Function Recovery[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(21): 188-192.
DOI：

SHI Juan-Juan, YUAN Zhuo, SHEN Li, et al. Effect of Modified Chaihu Shugan Tang in Treatment of Liver-Qi Stagnation Type of Post-stroke Depression and on Serum Nerve Transmitters and Nerve Function Recovery[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(21): 188-192. DOI： 10.13422/j.cnki.syfjx.20182029.

摘要

目的：探讨肝气郁结型卒中后抑郁（PSD）应用柴胡疏肝汤加减治疗的临床效果及对患者血清神经递质、神经功能恢复的影响。方法：选取2016年4月至2017年4月在天津中医药大学第一附属医院收治的86例肝气郁结型PSD患者，采用随机数字表法均分为两组。对照组（43例）予以氟西汀治疗，观察组（43例）采取柴胡疏肝汤加减治疗。记录比较两组临床疗效，治疗前后血清单胺类和氨基酸类神经递质水平及神经功能指标变化，不良反应发生情况。结果：观察组治疗6周后总有效率为95.4%（41/43），较对照组81.4%（35/43）明显升高（P<0.05）。与本组治疗前相比，两组治疗后血清多巴胺（DA），5-羟色胺（5-HT），去甲肾上腺素（NE）及甘氨酸（Gly）水平均显著升高（P<0.01），天冬氨酸（Asp），谷氨酸（Glu）水平均显著降低（P<0.01）；并以观察组改善更显著（P<0.01）。与本组治疗前比较，两组治疗后血清神经元烯醇化酶（NSE）水平，美国国立卫生研究院卒中量表（NIHSS）评分均显著降低（P<0.01），血清脑源性神经营养因子（BDNF）水平均显著升高（P<0.01）；且以观察组改善更显著（P<0.01）。两组均未见明显不良反应/事件。结论：肝气郁结型PSD应用柴胡疏肝汤加减治疗更能有效改善患者症状，调节机体神经递质表达，促进神经功能恢复，疗效显著且安全可靠。

Abstract

Objective: To investigate the clinical effect of Chaihu Shugan Tang in treating the liver-Qi stagnation type of post-stroke depression (PSD) and on serum nerve transmitters and nerve function recovery. Method: Totally 86 cases of the liver-Qi stagnation type of the liver-Qi PSD treated in our hospital from April 2016 to April 2017 were selected and divided into two groups with the random number table. The control group (43 cases) was treated with modified fluoxetine

and the observation group (43 cases) was treated with modified Chaihu Shugan Tang. The clinical efficacy

the levels of serum monoamine and amino acid neurotransmitters

the changes of neurological function and the incidence of adverse reactions were recorded and compared between the two groups. Result: The total effective rate in the observation group was 95.4% (41/43) after 6 weeks of treatment

which was significantly higher than 81.4% (35/43) in the control group (P<0.05). Compared with those before the treatment

serum dopamine (DA)

5-hydroxytryptamine (5-HT)

norepinephrine (NE) and glycine (Gly) levels all increased significantly in the two groups after the treatment (P<0.01)

and the levels of aspartic acid (Asp) and glutamic acid (Glu) decreased significantly (P<0.01); the improvement of the observation group was more significant (P<0.01). Compared with before the treatment

the levels of serum neuron enolase (NSE) and National Institutes of Health Stroke Scale (NIHSS) significantly decreased after the treatment in two groups (P<0.01). The level of serum brain derived neurotrophic factor (BDNF) increased significantly (P<0.01); the improvement of observation group was more significant (P<0.01). There was no obvious adverse reaction in the two groups. Conclusion: The application modified Chaihu Shugan Tang can effectively alleviate symptoms of cases of the liver-Qi stagnation type of the liver-Qi PSD

regulate neurotransmitter expression

and promote the recovery of neurological function

with a significant efficacy and safety.

关键词

Keywords

references

Views

164

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Jieyu Tongluo Method in Regulating Levels of Neurotransmitter from Patients with Post-stroke Depression

Effect and Mechanism of Modified Danzhi Xiaoyaosan in Treating Post-stroke Depression

Anmeidan Regulates Hepatic Neurotransmitters and Circadian Rhythm in Rat Model of Insomnia via OX1R/PLCβ-1/PKCα/ERK1/2 Signaling Pathway

Anti-convulsant Activity of Goat Horn and Its Effect on Neurotransmitters in Mouse Brain

Shenghuitang Mitigates Cognitive Impairment and Circadian Rhythm Disturbance in Mouse Model of Alzheimer's Disease via Regulating Expression Levels of Neurotransmitters

Related Author

Qing-li LI

Gui-xian WANG

Yan-jie WANG

Ming YANG

Zhong-feng XUE

Li-min JIANG

Xiang-zhe LIU

XU Bo

Related Institution

The Second Affiliated Hospital of Xinxiang Medical University

Guangxi University of Traditional Chinese Medicine

The First Affiliated Hospital of Henan University of Chinese Medicine

Hubei Shizhen Laboratory

Engineering Research Center of Chinese Medicine Protection Technology and New Product Development， Ministry of Education， Hubei University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰