Objective: To discuss the clinical efficacy of dialectical addition and subtraction of Jingfang Baidusan combined with ginger therapy at urinary bladder meridian to acute coughing (syndrome of wind-cold invading lung) caused by acute tracheitis and bronchitis

and to investigate its effect on inflammatory factors according to the academic thought of ‘cough’ established by professor FU Ru-mei. Method: One hundred and sixty eligible patients were randomly divided into control group (80 cases) and observation group (80 cases) by random number table. Both groups received ginger treatment at urinary bladder meridian. Patients in control group additionally got Tongxuan Lifei granules

9 g/time

tid. Patients in observation group additionally got dialectical addition and subtraction of Jingfang Baidusan combined

1 dose/day. The treatment course was 6 days in both groups. Symptom scores of cough

visual analogue scale (VAS)

and scores of syndrome of wind-cold invading lung were recorded both before and after treatment; in addition

prognosis of disease was also recorded. Before and after treatment

serum C reactive protein (CRP)

interleukin-4 (IL-4)

IL-6

interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) were detected. Result: After treatment

the total effective rate for the disease was 95.95% in observation group

better than 84.51% in control group (χ2=5.435

P<0.05). The total effective rate of cough was 97.30% in observation group

higher than 87.32% in control group (χ2=5.141

P<0.05). Scores of symptoms of cough (day

night and the total scores) and VAS of cough in the observation group were all lower than those in control group (P<0.01). Except for rhinobyon and fever

scores of other symptoms for syndrome of wind-cold invading lung and the total score in observation group were all lower than those in control group (P<0.01). The disappearance rates of cough

phlegm

flow and runny and pain of limbs in observation group were all higher than those in control group (P<0.01)

and there were no statistically significant differences in disappearance rates of cold and no sweat

nasal congestion

pharynx itching

and fever between two groups. In addition

the levels of CRP

IL-4

IL-6 and TNF-α in observation group were lower than those in control group

and level of IFN-γ was higher than that in control group (P<0.01). Conclusion: According to the academic thought of "cough" established by Professor Fu Rumei

dialectical addition and subtraction of Jingfang Baidusan combined as ginger treatment at urinary bladder meridian on cute coughing (syndrome of wind-cold invading lung) caused by tracheitis and bronchitis can ameliorate cough

promote disappearance of symptoms

improve clinical effect

and the anti-inflammatory can also be found.