Objective:To observe the efficacy of Runing granule in treating hyperplasia of mammary glands with syndrome of liver qi depression and phlegm stasis

and investigate its effects on progesterone(P)

estradiol (E2)

prolactin (PRL)

luteinizing hormone (LH)

follicle stimulating hormone (FSH) and angiogenic factors angiopoietin(Ang) -2

hypoxia inducible factor (HIF) -1α

vascular endothelial growth factor (VEGF)

and basic fibroblast growth factor (bFGF). Method:One hundred and twenty-two female patients with hyperplasia of mammary glands were selected and randomly divided into treatment group and control group with 61 cases in each group according to random number table. Both groups were orally with Xiaoyao wan(8 pills/time and tid). The patients in control group were additionally treated with Tamoxifen citrate tablets (20 mg/time and bid). Based on the treatment in control group

the patients in treatment group were additionally treated with Runing granule (1 bag/time and tid). Both groups were treated for 8 weeks. Scores of mammary gland hyperplasia symptoms

simple McGill pain questionnaire(SF-MPQ)

and symptoms of syndrome of liver Qi depression and phlegm stasis and efficacy were compared between two groups. Serum levels of P

E2

PRL

LH

and FSH as well as Ang-2

HIF-1α

VEGF

and bFGF were detected in both groups. Result:After treatment

scores of hyperplasia of mammary glands for breast lump hardness and gland tumor size

as well as SF-MPQ scale visual analogue scale (VAS)

present pain intensity (PPI)

pain rating index (PRI) of treatment group were evidently lower than those in control group (P<0.01). After treatment

scores of symptoms of syndrome of liver qi depression and phlegm stasis (depression and irritability

chest distress

insomnia and dreamy sleep

upset and bitter mouth) of treatment group were evidently lower than those of control group (P<0.01). Total clinical effective rate of treatment group was 98.31%

obviously higher than 86.89% in control group (χ2=4.319

P<0.05). After treatment

serum levels of E2

PRL

and LH in treatment group were remarkably lower

while P and FSH level were obviously higher than those in control group (P<0.01). After treatment

serum levels of ngiogenic factors Ang-2

HIF-1α

VEGF

and bFGF in treatment group were obviously lower than those in control group (P<0.01). Conclusion:Based on routine therapy

the efficacy of additional Runing Granule in treating hyperplasia of mammary glands with syndrome of liver qi depression and phlegm stasis is significant

which may be correlated with regulation of endocrine hormones (P

E2

PRL

LH

and FSH) and angiogenic factors (Ang-2

HIF-1α

VEGF

and bFGF).