Effect of Decocting Containers on Content of Sinapine and HPLC Specific Chromatograms of Sinapis Semen Decoction

Gang-yan YU; Yu-tao XUE; Li TAN; Xiang-long YU; Yu-jia MO; Ju-yuan LUO; Yang LU; Shou-ying DU; Jie BAI; Peng-yue LI

doi:10.13422/j.cnki.syfjx.20182303

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Effect of Decocting Containers on Content of Sinapine and HPLC Specific Chromatograms of Sinapis Semen Decoction

Pharmacy and Processing | 更新时间：2021-02-09

- Effect of Decocting Containers on Content of Sinapine and HPLC Specific Chromatograms of Sinapis Semen Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 1, Pages: 183-188(2019)
- 作者机构：
  
  北京中医药大学　中药学院，北京　 100029
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20182303
  CLC： R22;R94;R28;O657.7;TQ173.72
- Received：05 May 2018，
  
  Published Online：12 September 2018，
  
  Published：05 January 2019
- 稿件说明：
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Gang-yan YU, Yu-tao XUE, Li TAN, et al. Effect of Decocting Containers on Content of Sinapine and HPLC Specific Chromatograms of Sinapis Semen Decoction[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(1): 183-188.
DOI：

Gang-yan YU, Yu-tao XUE, Li TAN, et al. Effect of Decocting Containers on Content of Sinapine and HPLC Specific Chromatograms of Sinapis Semen Decoction[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(1): 183-188. DOI： 10.13422/j.cnki.syfjx.20182303.

摘要

目的：

比较4种煎药器皿对白芥子煎液中芥子碱含量及煎液特征图谱的影响，为经典名方的开发优选最佳的煎煮容器。

方法：

选择传统砂锅、陶瓷锅、圆底烧瓶、不锈钢锅4种煎煮器皿，以白芥子煎液中芥子碱含量及煎液的特征图谱为指标，探究不同煎煮器皿对白芥子指标性成分的含量和煎液特征图谱的影响。采用“中药色谱指纹图谱相似度评价系统”(2004A版)对特征图谱进行相似度评价。

结果：

传统砂锅、陶瓷锅、圆底烧瓶、不锈钢锅提取的芥子碱质量分数分别为0.04%，0.07%，0.84%，0.97%。传统砂锅与陶瓷锅、圆底烧瓶、不锈钢锅所制煎液的特征图谱相似度分别为0.98，0.82，0.68；陶瓷锅与圆底烧瓶、不锈钢锅所制煎液的特征图谱的相似度分别为0.79，0.62；圆底烧瓶与不锈钢锅所制煎液的特征图谱的相似度0.97。

结论：

不同煎煮容器所得白芥子煎液中芥子碱的含量有较大差异，传统砂锅与圆底烧瓶、不锈钢锅所得煎液的特征图谱的相似度较低。

Abstract

Objective:

To compare the effect of four kinds of decocting containers on the content of sinapine and the HPLC specific chromatograms of Sinapis Semen decoction

so as to optimize decocting container for the development of classical formulas.

Method:

Selecting four kinds of decoction vessels

named traditional casserole

ceramic pot

round-bottom flask and stainless-steel pot as the research object

the content of sinapine in Sinapis Semen decoction and its HPLC specific chromatograms were used as indexes to investigate the influence of different decoction vessels on the decoction.Similarity evaluation of specific chromatograms was performed by the " Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine" (edition of 2004A).

Result:

The contents of sinapine in the decoction prepared by traditional casserole

ceramic pot

round-bottom flask and stainless-steel pot were 0.04%

0.07%

0.84% and 0.97%

respectively.Compared with specific chromatograms of the decoction prepared by traditional casserole

the similarities of specific chromatograms of the decoction prepared by ceramic pot

round-bottom flask and stainless-steel pot were 0.98

0.82 and 0.68

respectively.Compared with specific chromatograms of the decoction prepared by ceramic pot

the similarities of specific chromatograms of the decoction prepared by round-bottom flask and stainless-steel pot were 0.79 and 0.62

respectively.Compared with specific chromatograms of the decoction prepared by round-bottom flask

the similarity of specific chromatograms of the decoction prepared by stainless-steel pot was 0.97.

Conclusion:

The content of sinapine and HPLC specific chromatograms of Sinapis Semen decoction obtained from different decocting containers are quite different.

关键词

Keywords

references

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The First Hospital of Hunan University of Chinese Medicine

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