Analysis of Molecular Mechanism of Dingxiang Shiditang for Hiccup and Vomit Based on Integrated Pharmacology

Fang-fang DING; Xiu-juan PENG; Wen-qiang TANG; Rui-rui ZHANG; Feng LIU

doi:10.13422/j.cnki.syfjx.20182307

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Analysis of Molecular Mechanism of Dingxiang Shiditang for Hiccup and Vomit Based on Integrated Pharmacology

Pharmacology | 更新时间：2021-02-09

- Analysis of Molecular Mechanism of Dingxiang Shiditang for Hiccup and Vomit Based on Integrated Pharmacology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 3, Pages: 100-107(2019)
- 作者机构：
  
  1.陕西国际商贸学院，陕西　咸阳　 712046
  2.陕西步长制药有限公司，西安　 710075
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20182307
  CLC： R22;R24;R28;C37;R256.31
- Received：07 March 2018，
  
  Published Online：12 September 2018，
  
  Published：05 February 2019
- 稿件说明：
移动端阅览
Fang-fang DING, Xiu-juan PENG, Wen-qiang TANG, et al. Analysis of Molecular Mechanism of Dingxiang Shiditang for Hiccup and Vomit Based on Integrated Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(3): 100-107.
DOI：

Fang-fang DING, Xiu-juan PENG, Wen-qiang TANG, et al. Analysis of Molecular Mechanism of Dingxiang Shiditang for Hiccup and Vomit Based on Integrated Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(3): 100-107. DOI： 10.13422/j.cnki.syfjx.20182307.

摘要

目的:

探讨经典名方丁香柿蒂汤降逆止呃的分子作用机制，为该方的后续研究与开发具有提供参考。

方法:

利用中药整合药理学平台，从多成分、多靶标的维度揭示丁香柿蒂汤降逆止呃的潜在分子机制。

结果:

丁香柿蒂汤降逆止呃作用主要与89个化学成分相关，共有靶标1个[大麻素受体1(CNR1)]，CNR1一方面通过抑制

-氨基丁酸(GABA)，多巴胺和5-羟色胺(5-HT)的释放而抑制呃逆的发生；另一方面，CNR1激活可抑制胃肠动力、延迟胃排空，推测可能是通过脑-肠轴发挥调节胃肠运动的作用。同时，丁香柿蒂汤降逆止呃作用可能与神经系统、核苷酸代谢相关。

结论:

丁香柿蒂汤可能是通过影响神经递质的释放、线粒体能量代谢等调节胃肠运动，基于多靶标、多通路共同干预实现其降逆止呃的作用。

Abstract

Objective:

The classical formula of Dingxiang Shiditang can be used for hiccup and vomit which caused by many reasons

its molecular mechanism of this formula was investigated.

Method:

Based on the integrated pharmacology platform of traditional Chinese medicine

the potential molecular mechanism of Dingxiang Shiditang was revealed from the dimensions of multi-components and multi-targets.

Result:

There were 89 compounds related to hiccup and vomit of Dingxiang Shiditang

and there was 1 common target[cannabinoid receptor 1(CNR1)]. On the one hand

CNR1 could inhibit the occurrence of hiccup and vomit by inhibiting the release of

-aminobutyric acid(GABA)

dopamine

5-hydroxytryptamine(5-HT); on the other hand

CNR1 could inhibit gastrointestinal motility and delay gastric emptying

and it was speculated that CNR1 may play a role in regulating gastrointestinal motility through brain-gut axis.Meanwhile

the mechanism of Dingxiang Shiditang may be related to nucleotide metabolism and nervous system.

Conclusion:

Dingxiang Shiditang may regulate gastrointestinal motility by affecting the release of neurotransmitters

mitochondrial energy metabolism

and achieve its effect on hiccup and vomit based on the joint intervention of multiple targets and multiple pathways.

关键词

Keywords

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