Analysis of Molecular Mechanism of Huangliantang in Treatment of Gastritis Based on Integrated Pharmacology Platform of Traditional Chinese Medicine

Zhi-chun WU; Hua-yun YU; Cheng-bo ZHANG; Ting MA; Xin ZONG; Xu-ming JI

doi:10.13422/j.cnki.syfjx.20182308

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Analysis of Molecular Mechanism of Huangliantang in Treatment of Gastritis Based on Integrated Pharmacology Platform of Traditional Chinese Medicine

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- Analysis of Molecular Mechanism of Huangliantang in Treatment of Gastritis Based on Integrated Pharmacology Platform of Traditional Chinese Medicine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 4, Pages: 57-62(2019)
- 作者机构：
  
  1.山东中医药大学，济南　 250355；
  2.浙江中医药大学，杭州　 310053
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20182308
  CLC： R22;R24;R28;C37;R573.3
- Received：07 March 2018，
  
  Published Online：12 September 2018，
  
  Published：20 February 2019
- 稿件说明：
移动端阅览
Zhi-chun WU, Hua-yun YU, Cheng-bo ZHANG, et al. Analysis of Molecular Mechanism of Huangliantang in Treatment of Gastritis Based on Integrated Pharmacology Platform of Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(4): 57-62.
DOI：

Zhi-chun WU, Hua-yun YU, Cheng-bo ZHANG, et al. Analysis of Molecular Mechanism of Huangliantang in Treatment of Gastritis Based on Integrated Pharmacology Platform of Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(4): 57-62. DOI： 10.13422/j.cnki.syfjx.20182308.

摘要

目的：

探讨黄连汤治疗胃炎的功效物质基础和可能的作用机制，为该复方的后续应用与研发提供参考。

方法：

利用中药整合药理学平台预测黄连汤治疗胃炎的主要活性成分和作用靶点，构建黄连汤成分靶标-疾病靶标网络，筛选关键节点进行通路富集分析，探索黄连汤多成分-多靶点-多通路治疗胃炎的可能作用机制。

结果：

黄连汤预测的175个活性成分与胃炎相关的538个关键靶标相互作用，通过趋化因子、雌激素和T细胞受体等信号通路参与幽门螺旋杆菌感染侵润、胃黏膜损伤、胃黏膜萎缩等胃炎发生与发展过程中病理环节的调控。

结论：

该研究初步揭示了黄连汤治疗胃炎的潜在活性成分及其可能的作用机制，为该方进一步的药效物质基础和作用机制实验研究提供了理论依据。

Abstract

Objective:

To investigate the effective substance basis and possible mechanism of Huangliantang in treatment of gastritis.

Method:

Integrated pharmacology platform of traditional Chinese medicine was employed to predict the main active ingredients and functional targets of Huangliantang in treatment of gastritis

network of composition target-disease target of Huangliantang was constructed

key nodes were screened for enrichment analysis of pathways

and the possible mechanism of Huangliantang in treatment of gastritis with multiple ingredients-multiple targets-multiple pathways was explored.

Result:

A total of 175 predicted active ingredients of Huangliantang interacted with 538 key targets about gastritis

the regulation and treatment of gastritis during its different pathological stages

such as

Helicobacter pylori

infection

gastric mucosal damage and gastric mucosal atrophy

were involved through chemokine

T cell receptor

estrogen and other signaling pathways.

Conclusion:

This research may reveal the potential active ingredients of Huangliantang in treatment of gastritis and its possible mechanism

and it also provides a theoretical basis for further experimental research of pharmacodynamic substance basis and mechanism of action.

关键词

Keywords

references

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