Summary and Review of Animal Models for Chronic Atrophic Gastritis and Precancerous Lesions of Gastric Cancer

Ling LIN; Tao HAN; Lu LU; Qian-qian SUN; Ming-yu SUN

doi:10.13422/j.cnki.syfjx.20182329

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Summary and Review of Animal Models for Chronic Atrophic Gastritis and Precancerous Lesions of Gastric Cancer

Review | 更新时间：2021-02-09

- Summary and Review of Animal Models for Chronic Atrophic Gastritis and Precancerous Lesions of Gastric Cancer
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 2, Pages: 220-227(2019)
- 作者机构：
  
  1.山东中医药大学，济南　 250355；
  2.上海中医药大学　附属曙光医院肝病研究所，上海　 201203；
  3.上海中医药大学，上海　 201203
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20182329
  CLC： R22; R242; R2-031; R273; R287
- Received：15 April 2018，
  
  Published Online：13 September 2018，
  
  Published：20 January 2019
- 稿件说明：
移动端阅览
Ling LIN, Tao HAN, Lu LU, et al. Summary and Review of Animal Models for Chronic Atrophic Gastritis and Precancerous Lesions of Gastric Cancer[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(2): 220-227.
DOI：

Ling LIN, Tao HAN, Lu LU, et al. Summary and Review of Animal Models for Chronic Atrophic Gastritis and Precancerous Lesions of Gastric Cancer[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(2): 220-227. DOI： 10.13422/j.cnki.syfjx.20182329.

摘要

胃癌是目前在全球范围中发病率和死亡率较高的一种疾病，也是在全球医学界作为重点关注的疾病。胃癌的发生是一个多重阶段、多重因素的过程。大量流行病学、病理学和临床证据证实，慢性萎缩性胃炎(chronic atrophic gastritis，CAG)患者的胃癌罹患风险增高，CAG的患病率与胃癌死亡率高度相关。胃黏膜萎缩和肠上皮化生(特别是不完全型结肠化生)及异型增生是胃癌的癌前病变(precancerous lesions of gastric cancer，PLGC)的主要阶段。对CAG患者尤其是伴有肠化和异型增生者进行病情监测，对于早期胃癌的发现意义重大。CAG与PLGC作为在胃癌发生过程中的重要病理阶段意义非凡，近年来与此相关的深入临床及实验研究越来越多。迄今为止，动物实验是CAG与PLGC疾病实验方向的主要研究途径，所以造模方法的探索显得尤为关键，选择一个稳定可靠的模型是研究动物实验的首要因素。鉴于两种疾病的关联性，本文总结了近年来CAG与PLGC动物模型的建立方法，大致分为化学药物诱变法、物理方式刺激法、免疫造模法、幽门螺杆菌感染复制法以及手术造模法，对各种方法在之前实验中的应用分别举例，并加以笔者后续探索而且已经成功的实验造模方法，同时对各种方法的优缺点做简要评述，为今后CAG与PLGC实验中动物模型的建立和应用提供一定的参考。

Abstract

Gastric cancer is a disease with high morbidity and mortality in the world

and also obtains attention in the global medicine. The occurrence of gastric cancer is a multi-stage and multi-factor process. A large number of epidemiological

pathological and clinical evidences have confirmed that the risk of gastric cancer in patients with chronic atrophic gastritis (CAG) is significantly correlated with the mortality of gastric cancer. Gastric mucosal atrophy

intestinal metaplasia (especially incomplete colonic metaplasia) and dysplasia are the main stages of precancerous lesions of precancerous lesions of gastric cancer (PLGC). Monitoring the condition of CAG patients

especially those with intestinal metaplasia and dysplasia

is of great significance for the discovery of early gastric cancer. CAG and PLGC are great significance in the pathological stage of gastric carcinogenesis. In recent years

more and more in-depth clinical and experimental studies have been carried out in this direction. So far

animal experiment is the main research way for CAG and PLGC disease

so it is very important to explore the modeling method. Choosing a stable and reliable model is the primary factor to study animal experiment. In view of the relationship between two diseases

this paper will summarize the methods of establishing animal models for CAG and PLGC in recent years

generally including chemical drug mutagenesis

physical stimulation

immune modeling

Helicobacter pylori

infection replication and surgical modeling. Examples would be given for the application of various methods in the previous experiments

and the author would make a brief comment on the merits and demerits of these methods

which have been explored and successfully made by the author. This study would provide certain reference for the establishment and application of animal models in further CAG and PLGC experiments.

关键词

Keywords

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