Diabetic nephropathy (DN) is one of the most important microvascular complications of diabetes

and the mortality caused by end-stage renal failure is very high. Current studies have discovered many factors affecting the development of DN

and the pathogenesis is complicated. Among them

oxidative stress caused by hyperglycemia

abnormal expression of cytokines

increased renal inflammatory reaction

renal hemodynamic changes and disorders of glycolipid metabolism are the main causes for DN. Western medicine used in clinical practice has a certain effect on the treatment of DN. Its main therapeutic mechanism is to reduce glycolipid

which however cannot fundamentally prevent the occurrence and development of DN. In addition

the treatment of DN is a long process

which requires long-term use of western medicine

and cause toxic side effects and economic burden on patients. In this case

traditional Chinese medicines(TCM) show great advantages in the treatment of multi-factor-induced DN. Many TCM have a variety of pharmacological properties

such as anti-oxidation

immune regulation

cardiovascular nutrition

lipid-lowering and hypoglycemic effects. With respect to the advantages of TCM

there have been many studies on the treatment of DN with TCM

and many drugs with good effects have been discovered. Clinical studies have shown that TCM for promoting blood circulation and removing phlegm can significantly reduce urinary protein

improve clinical symptoms

delay the occurrence and development of DN

and improve the quality of life of patients. To this end

this paper reviews the mechanisms of TCM for promoting blood circulation and removing blood stasis in the treatment of DN

and provides a scientific theoretical basis for the treatment of DN with TCM for promoting blood circulation and removing blood stasis from the perspective of molecular biology.