Objective:To observe the efficacy of modified Simiao Wan and Shixiaosan combined with Qianlie Beixi capsule in treating type Ⅲ chronic prostatitis with syndrome of damp-heat stagnation

and investigate its effect on levels of Th1/Th2 and cytokines. Method:One hundred and fifty-two type Ⅲ prostatitis patients were selected and randomly divided into control group (76 cases) and observation group (76 cases) by random number table. The patients in control group were given with Qianlie Beixi capsules (6 capsules/time before meals

tid). Based on the treatment in control group

the patients in observation group were additionally treated with modified Simiao pills and Shixiao San (1 dose/day

tid). Both groups were treated for 6 weeks. Then the scores of National Institutes of Health-chronic prostatitis symptom index (NIH-CPSI) and symptoms of damp-heat stagnation syndrome (frequent urination

urine pain

perineum and other local pain

scrotum wet

dripping urine

yellow turbidity

hot and dampness pain) were compared between two groups. The clinical efficacy and syndrome efficacy were analyzed for both groups. Peripheral blood levels of Th1 and Th2 and serum levels of interleukin(IL) -2

IL-4

IL-6

IL-10

tumor necrosis factor (TNF) -α and interferon (IFN) -γ were detected in two groups. Adverse reactions were also monitored in both groups. Result:After treatment

scores of pain discomfort

urinary symptoms

quality of life

NIH-CPSI total score and damp-heat stagnation symptoms in observation group were obviously lower than those in control group (P<0.01). Total clinical efficacy rate was 96.05% in observation group

higher than 84.21% in control group (P<0.05). Total syndrome efficacy rate was 97.37% in observation group

higher than 84.21% in control group (P<0.05). After treatment

peripheral blood levels of Th1 and Th1/Th2 in observation group were lower

while Th2 level was higher than those in control group (P<0.01). Serum levels of IL-2

IL-4

and IL-10 in observation group were significantly higher

while serum levels of IL-6

TNF-α and IFN-γ were lower than those in control group (P<0.01). Adverse reaction rate was 3.95% in control group and 5.26% in observation group

with no significant difference between two groups. Conclusion:Modified Simiaowan and Shixiaosan combined with Qianlie Beixi capsule in treating type Ⅲ chronic prostatitis with syndrome of damp-heat stagnation can improve clinical symptoms and syndrome indexes

increase the efficacy with a good safety

and regulate levels of Thl/Th2 and cytokines to restore balance.