Analysis of Fingerprint of Standard Decoction of Citri Reticulatae Pericarpium Based on Spectroscopic Method

Tao LIU; Yu-xue ZHANG; Jia ZHANG; Meng-die XIE; Chun-hui PAN; Hui YANG; Yan-jun DENG; Tian-yu JIANG; Yu-ling XU

doi:10.13422/j.cnki.syfjx.20182407

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Analysis of Fingerprint of Standard Decoction of Citri Reticulatae Pericarpium Based on Spectroscopic Method

Pharmacy and Processing | 更新时间：2021-02-09

- Analysis of Fingerprint of Standard Decoction of Citri Reticulatae Pericarpium Based on Spectroscopic Method
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 6, Pages: 136-143(2019)
- 作者机构：
  
  1.成都大学　药学与生物工程学院，成都　 610106；
  2.四川德成动物保健品有限公司，四川　德阳　 618100
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20182407
  CLC： R22;O657.7;R28;C37;O433
- Received：10 May 2018，
  
  Published Online：2018-29-09，
  
  Published：20 March 2019
- 稿件说明：
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Tao LIU, Yu-xue ZHANG, Jia ZHANG, et al. Analysis of Fingerprint of Standard Decoction of Citri Reticulatae Pericarpium Based on Spectroscopic Method[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(6): 136-143.
DOI：

Tao LIU, Yu-xue ZHANG, Jia ZHANG, et al. Analysis of Fingerprint of Standard Decoction of Citri Reticulatae Pericarpium Based on Spectroscopic Method[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(6): 136-143. DOI： 10.13422/j.cnki.syfjx.20182407.

摘要

目的：

建立陈皮饮片标准汤剂的指纹图谱并对其进行质量评价。

方法：

制备15批陈皮饮片标准汤剂，采用HPLC测定陈皮饮片标准汤剂中橙皮苷的含量；采用紫外光谱法(UV)和红外光谱法(IR)建立陈皮饮片标准汤剂的指纹图谱；利用相关系数法和双指标序列分析法对不同批次陈皮饮片标准汤剂的光谱图进行比对。

结果：

15批陈皮饮片标准汤剂中橙皮苷的质量分数0.82%～2.60%，出膏率实测值32.02%～46.11%；与紫外和红外对照指纹图谱相比，各批次陈皮饮片标准汤剂指纹图谱的相似度分别为>0.897和>0.942，双指标分析法结果显示各批次陈皮饮片标准汤剂的共有峰率均>62.50%，变异峰率均<46.67%。

结论：

该研究建立的质量评价方法可用于陈皮饮片标准汤剂的系统性评价，可为陈皮配方颗粒等相关制剂的质量标准制定提供参考。

Abstract

Objective:

To establish the fingerprint of standard decoction of Citri Reticulatae Pericarpium and evaluate its quality.

Method:

According to the preparation conditions of the standard decoction

15 batches of standard decoction of Citri Reticulatae Pericarpium were prepared. HPLC was employed to determine the content of hesperidin in this standard decoction. Ultraviolet spectroscopy(UV) and infrared spectroscopy(IR) were used to establish the fingerprint of standard decoction of Citri Reticulatae Pericarpium. The correlation coefficient method and double index sequence analysis method were used to compare and analyze the spectra of different batches of this standard decoction.

Result:

The content of hesperidin in 15 batches of this standard decoction were 0. 82%-2. 60%

and the measured value of dry extract rate was 32. 02%-46. 11%. Compared with ultraviolet and infrared control fingerprint

the fingerprint similarities of the standard decoction of each batch were >0. 897 and >0. 942

respectively. The double index analysis results showed that the common peak ratio was more than 62. 50%

variation peak ratio was less than 46. 67%.

Conclusion:

The quality evaluation method established in this study can be used for systematic evaluation of standard decoction of Citri Reticulatae Pericarpium

and it can provide theoretical reference for the formulation of quality standard of Citri Reticulatae Pericarpium dispensing granules and other related preparations.

关键词

Keywords

references

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