Effect of Heat Treatment on Contents of Sulfur Dioxide Residue and  Sulfur-containing Derivatives in Sulfur-fumigated Codonopsis Radix

Fei XU; Ming KONG; Jin-di XU; Song-lin LI; Yan JIANG

doi:10.13422/j.cnki.syfjx.20182414

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Effect of Heat Treatment on Contents of Sulfur Dioxide Residue and Sulfur-containing Derivatives in Sulfur-fumigated Codonopsis Radix

Quality Evaluation | 更新时间：2021-02-09

- Effect of Heat Treatment on Contents of Sulfur Dioxide Residue and Sulfur-containing Derivatives in Sulfur-fumigated Codonopsis Radix
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 3, Pages: 162-166(2019)
- 作者机构：
  
  1.南京林业大学　化学工程学院，南京　 210037
  2.南京中医药大学　附属中西医结合医院，南京　 210028
  3.江苏省中医药研究院&中国中医科学院江苏分院，南京　 210028
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20182414
  CLC： R282.4;R289;R22;R2-031
- Received：04 May 2018，
  
  Published Online：29 September 2018，
  
  Published：05 February 2019
- 稿件说明：
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Fei XU, Ming KONG, Jin-di XU, et al. Effect of Heat Treatment on Contents of Sulfur Dioxide Residue and Sulfur-containing Derivatives in Sulfur-fumigated Codonopsis Radix[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(3): 162-166.
DOI：

Fei XU, Ming KONG, Jin-di XU, et al. Effect of Heat Treatment on Contents of Sulfur Dioxide Residue and Sulfur-containing Derivatives in Sulfur-fumigated Codonopsis Radix[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(3): 162-166. DOI： 10.13422/j.cnki.syfjx.20182414.

摘要

目的:

通过测定热处理前后硫熏党参中二氧化硫残留和含硫衍生物量的变化规律，评估硫熏党参热处理脱硫技术的可行性。

方法:

采用酸碱滴定法测定硫熏党参中二氧化硫残留量；采用UPLC-Q-TOF-MS/MS定性和半定量表征硫熏党参中含硫衍生物；对不同硫磺熏蒸时间和不同热处理时间的硫熏党参中二氧化硫残留量与含硫衍生物含量的变化进行相关性分析。

结果:

白术内酯Ⅱ含硫衍生物和白术内酯Ⅲ含硫衍生物为硫熏党参主要特征含硫衍生物。随硫熏程度的增加，党参中二氧化硫残留量显著增加，含硫衍生物的含量先增加后维持稳定，二氧化硫残留量与含硫衍生物的量之间并不一定呈正相关；随热处理程度增加，硫熏党参中二氧化硫残留量持续明显下降，但含硫衍生物的量先下降后维持稳定并保持在较高的含量水平，相关性分析结果表明热处理脱硫所致的党参药材二氧化硫残留与含硫衍生物量的变化并不一定呈正相关。

结论:

热处理虽然可显著降低硫熏党参中二氧化硫残留量，但药材中仍存在含量较高的含硫衍生物，不能使硫熏党参内在质量恢复到与非硫熏品质一致。因此，热处理脱硫技术不是保证硫熏党参质量的可行技术。

Abstract

Objective:

To evaluate the feasibility of heat-treating de-sulfur method for sulfur-fumigated Codonopsis Radix (CR) by investigating the changes in contents of sulfur dioxide residue and sulfur-containing derivatives after sulfur-fumigation.

Method:

Qualitative and semi-quantitative characterization of sulfur-containing derivatives was analyzed by ultra-performance liquid chromatography-quadrupole-time of flight-mass spectrometry (UPLC-Q-TOF-MS/MS)

and sulfur dioxide residues were determined by acid-base titration method. Then the correlations between sulfur dioxide residues and sulfur-containing derivatives in sulfur-fumigated CR samples with different sulfur-fumigation and heat treatment extents were analyzed.

Result:

Atractylenolide Ⅱ and atractylenolide Ⅲ sulfur-containing derivatives were identified as major characteristic markers of sulfur fumigated CR. With the increase of sulfur-fumigation time

the content of sulfur dioxide residues was continuously increased

while the content of sulfur-containing derivatives was elevated at the beginning and then reached to a plateau

so there was not necessarily a positive correlation between sulfur dioxide residue and the amount of sulfur derivatives. With the increase of heat-treated time

the content of sulfur dioxide residues was continuously decreased

while the content of sulfur-containing derivatives was decreased first and remained at a high level later. There was no clear correlation between sulfur dioxide residue and sulfur-containing derivatives in different sulfur-fumigated and heat-treating de-sulfur degrees of CR.

Conclusion:

Heat-treatment could decrease the content of sulfur dioxide residue

but the content of sulfur-containing derivatives still remained at a high level

so heat treatment could not reinstate the inner quality of sulfur-fumigated CR to its non-fumigated ones. Therefore

heat-treating de-sulfur is not a feasible method for the quality assurance of sulfur-fumigated CR.

关键词

Keywords

references

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