Objective: To discuss the clinical efficacy of syndrome differentiation therapy of Yushen Peiyuan decoction for endometrial hyperplasia (EH) with syndrome of kidney deficiency and blood stasis and investigate its effects on endocrine hormone levels and hemorheology. Method: One hundred and forty patients were randomly divided into control group (70 cases) and observation group (70 cases) by random number table. Patients in control group got medroxyprogesterone acetate (MPA) for 3 menstrual cycles from the second week after curettage

10 mg/time

2 times/days. Based on the treatment in control group

patients in observation group additionally received syndrome differentiation therapy of Yushen Peiyuan decoction for 3 menstrual cycles

1 dose/day

medication stopped during the menstruation. In addition

3 months' follow-up was recorded. At the 14th-16th in menstrual cycle

endometrium thickness was detected by transvaginal ultrasound; menstrual volume scores were evaluated by pictorial blood loss assessment chart(PBAC)and scores of kidney deficiency and blood stasis syndrome were recorded before and after treatment and at the end of follow-up. Before and after treatment

levels of luteinizing hormone (LH)

follicle stimulating hormone (FSH)

estrogen (E2)

progesterone (P) and hemorheological indexes were detected

and endometrial biopsy was used to evaluate the endometrial reversal rate. During follow-up for 3 menstrual cycles

recurrence rate was recorded. Result: The total clinical effective rate was 95.16% in observation group

higher than 81.67% in control group (χ2=5.466

P<0.05). After treatment

the scores of endometrium thickness

PBAC and syndrome of kidney deficiency and blood stasis in observation group were all lower than those in control group (P<0.01). During follow-up period

scores of endometrium thickness

PBAC and syndrome of kidney deficiency in observation group were significantly increased in control group as compared with the data after treatment (P<0.01)

but the changes in observation group showed no statistical significance; and scores of endometrium thickness

PBAC and syndrome of kidney deficiency in observation group were lower than those in control group during follow-up period (P<0.01). Level of serum P in observation group was higher and level of E2 was lower than that in control group (P<0.01). The amelioration of hemorheological indexes such as whole blood viscosity (high

low shear)

plasma viscosity

platelet aggregation and fibrinogen in observation group were better than that in control group (P<0.01). Reversal rate of endometrium was 93.55% in observation group

higher than 76.67% in control group (χ2=5.407

P<0.05)

and recurrence rate was 5.26% in observation group

lower than 19.57% in control group (χ2=5.058

P<0.05). Conclusion: Yushen Peiyuan decoction combined with MPA can relieve clinical symptoms in patients with EH and syndrome of kidney deficiency and blood stasis

ameliorate hemorheology

improve endometrial reversal rate

and reduce recurrence rate

with better clinical efficacy than MPA treatment alone.