Comparison Between Traditional and Integrated Processing Technology of Leonuri Herba Based on Chemical Composition and Pharmacological Effect

Jing-jing QIAO; Qi-nan WU; Min XUE; Qian WANG; An-na XU; Da-wei WU

doi:10.13422/j.cnki.syfjx.20190104

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Comparison Between Traditional and Integrated Processing Technology of Leonuri Herba Based on Chemical Composition and Pharmacological Effect

Pharmacy and Processing | 更新时间：2021-02-09

- Comparison Between Traditional and Integrated Processing Technology of Leonuri Herba Based on Chemical Composition and Pharmacological Effect
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 8, Pages: 101-107(2019)
- 作者机构：
  
  南京中医药大学　药学院，江苏省中药资源产业化过程协同创新中心，中药资源产业化与方剂创新药物国家地方联合工程研究中心，南京　 210023
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190104
  CLC： R22;R24;R28;C37;R931
- Received：10 June 2018，
  
  Published：20 April 2019
- 稿件说明：
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Jing-jing QIAO, Qi-nan WU, Min XUE, et al. Comparison Between Traditional and Integrated Processing Technology of Leonuri Herba Based on Chemical Composition and Pharmacological Effect[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 101-107.
DOI：

Jing-jing QIAO, Qi-nan WU, Min XUE, et al. Comparison Between Traditional and Integrated Processing Technology of Leonuri Herba Based on Chemical Composition and Pharmacological Effect[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 101-107. DOI： 10.13422/j.cnki.syfjx.20190104.

摘要

目的：

比较益母草传统加工饮片与一体化加工饮片在化学成分含量与药理作用方面的差异，阐述益母草一体化加工工艺的合理性。

方法：

选择盐酸水苏碱、盐酸益母草碱、芦丁、金丝桃苷、异槲皮苷的含量为指标，比较2种加工工艺益母草饮片中化学成分含量的差异；以二甲苯致小鼠耳廓肿胀模型，考察2种加工工艺益母草饮片抗炎作用的差异；采用大鼠急性血瘀模型，考察2种加工工艺益母草饮片对全血黏度和凝血功能指标的影响。

结果：

益母草一体化工艺饮片中盐酸水苏碱、盐酸益母草碱、芦丁、金丝桃苷、异槲皮苷的质量分数分别为1.558%，0.168%，0.137%，0.113%，0.078%；传统工艺饮片中则分别为1.482%，0.134%，0.125%，0.082%，0.071%。2种工艺饮片均能降低致炎小鼠耳肿胀度、降低致炎小鼠血清中肿瘤坏死因子-

(TNF-

)，白细胞介素(IL)-1

和IL-6的含量，产生抗炎作用；同剂量组间比较，一体化工艺组整体优于传统工艺组。2种加工饮片均能降低急性血瘀模型大鼠的全血黏度，延长凝血酶时间(TT)，凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)，降低血浆纤维蛋白原(FIB)的质量浓度；同剂量组间比较，一体化工艺组整体优于传统工艺组。

结论：

与传统加工工艺相比，益母草一体化加工工艺在保证饮片质量的同时，降低了生产成本，且所得饮片化学成分与药理作用均略高于传统加工饮片，表明该药材选择一体化加工具有一定的合理性。

Abstract

Objective:

To elucidate the rationality of integrated processing technology of Leonuri Herba based on comparison of chemical constituents and pharmacological effect of Leonuri Herba between traditional and integrated processing technology.

Method:

The contents of stachydrine hydrochloride

leonurine hydrochloride

rutin

hyperoside and isoquercetin were used as indexes to compare the differences in the contents of chemical constituents between traditional and integration processing technology of Leonuri Herba.Effect of Leonuri Herba with different processing technology on auricular swelling induced by dimethylbenzene in mice were observed to compared the differences of their anti-inflammatory effect.And rat acute blood stasis model was used to compare the differences of Leonuri Herba with different processing technology on hemorheology and blood coagulation indexes.

Result:

Contents of stachydrine hydrochloride

leonurine hydrochloride

rutin

hyperoside and isoquercetin in products of integrated processing were 1.558%

0.168%

0.137%

0.113% and 0.078%

they were 1.482%

0.134%

0.125%

0.082% and 0.071% in products of traditional processing

respectively.Both of the processing methods could reduce the degree of swelling and the contents of tumor necrosis factor(TNF)-

interleukin(IL)-1

IL-6 in mouse serum.And both of the processing methods could reduce the whole blood viscosity

prolong the thrombin time(TT)

prothrombin time(PT)

activated partial thromboplastin time(APTT) and reduce the concentration of plasma fibrinogen(FIB) in acute blood stasis model rats.

Conclusion:

Compared with the traditional processing technology

the integrated processing technology is better in guaranteeing the quality of Leonuri Herba decoction pieces and reducing the production cost

which indicates that the integrated processing of Leonuri Herba is reasonable.

关键词

Keywords

references

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