Clinical Effect of Jinlida and Tongxinluo on Type 2 Diabetic Kidney Disease Under Vessel Collateral Theory

Hong-li LIU; Jin-yue TIAN; Geng WEI; Chao-ying WU

doi:10.13422/j.cnki.syfjx.20190115

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Clinical Effect of Jinlida and Tongxinluo on Type 2 Diabetic Kidney Disease Under Vessel Collateral Theory

Clinic | 更新时间：2021-02-09

- Clinical Effect of Jinlida and Tongxinluo on Type 2 Diabetic Kidney Disease Under Vessel Collateral Theory
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 1, Pages: 157-162(2019)
- 作者机构：
  
  石家庄市第二医院，石家庄　 050035
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190115
  CLC： R22;R2-031;R242;R287
- Received：17 April 2018，
  
  Published Online：17 October 2018，
  
  Published：05 January 2019
- 稿件说明：
移动端阅览
Hong-li LIU, Jin-yue TIAN, Geng WEI, et al. Clinical Effect of Jinlida and Tongxinluo on Type 2 Diabetic Kidney Disease Under Vessel Collateral Theory[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(1): 157-162.
DOI：

Hong-li LIU, Jin-yue TIAN, Geng WEI, et al. Clinical Effect of Jinlida and Tongxinluo on Type 2 Diabetic Kidney Disease Under Vessel Collateral Theory[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(1): 157-162. DOI： 10.13422/j.cnki.syfjx.20190115.

摘要

目的：

观察脉络学说指导下津力达颗粒联合通心络胶囊治疗2型糖尿病肾病的临床疗效。

方法：

将120例2型糖尿病肾病患者随机分为对照组和治疗组，各60例，对照组予常规降糖降压等对症支持治疗，治疗组在对照组治疗基础上加津力达颗粒，1袋/次，3次/日，通心络胶囊4粒，3次/日，12周为1个疗程，治疗前后观察并比较两组患者的临床疗效、中医证候积分；糖代谢指标空腹血糖（FBG），餐后2 h血糖（2 hPG），糖化血红蛋（HbA1c），胰岛素抵抗指数（HOMA-IR）；脂代谢指标甘油三酯（TG），胆固醇（TC），低密度脂蛋白（LDL-C），高密度脂蛋白（HDL-C）；肾功能血肌酐（SCr），尿白蛋白排泄率（UAER），尿

微球蛋白（U

-MG）；甲襞微循环。

结果：

①对照组、治疗组临床总有效率分别为61.67%，80.00%，治疗组明显优于对照组（

0.05）。②中医证候积分改善比较，治疗组优于对照组（

0.05）。③治疗后治疗组在糖代谢指标FBG，2 hPG

HbA1c上与对照组无明显差异，HOMA-IR改善优于对照组（

0.05）；脂代谢指标TG

LDL-C均明显降低（

0.05），HDL-C升高（

0.05）；肾功能指标SCr

UAER，尿U

-MG改善较对照组明显（

0.05）；甲襞微循环结果显示，治疗组较对照组微循环改善明显（

0.05）。

结论：

通心络联合津力达可改善2型糖尿病肾病患者的临床症状，降低尿微量白蛋白，其机制可能与降糖、调节脂质代谢、改善微循环有关。

Abstract

Objective:

To observe the clinical efficacy of Jinlida (JLD) granules and Tongxinluo (TXL) capsules on type 2 diabetic kidney disease (DKD) under the guidance of vessel collateral theory.

Method:

A total of 120 patients with type 2 DKD

were randomly divided into 2 groups: the normal control group (60 cases) and the treatment group (60 cases). The patients in normal control group were treated with dietary control and hyperglycemia control. Based on treatment in control group

patients in treatment group were additionally treated with JLD granules (1 bag

tid

)

and TXL capsules (4 capsules

tid

). The treatment was lasted for 12 weeks. The clinical efficacy

traditional Chinese medicine(TCM) syndrome scores were observed and compared before and after treatment. At the same time

the levels of glucose metabolism indexes including fasting blood glucose (FBG)

postprandial 2 h plasma glucose (2 hPG)

glycosylated hemoglobin (HbA1c) and the insulin resistance (IR); the levels of lipid metabolism indexes including total cholesterol(TC)

triglyceride (TG)

low-density lipoprotein cholesterol (LDL-C) and the high-density lipoprotein cholesterol (HDL-C); the levels of renal function indexes including urinary albumin excretion rate (UAER) and serum creatinine (SCr); as well as nailfold microcirculation were detected and compared.

Result:

①The total effective rate was 80.0% in treatment group

significantly higher than 61.67% in the normal control group (

0.05). ②The improvement in TCM syndrome scores of the treatment group was better than that of the control group

and the difference was statistically significant (

0.05). ③After treatment

the treatment group showed no significant difference with the control group in glucose metabolism indexes FBG

2 hPG and HbA1c

but HOMA-IR improvement was better than that of control group (

0.05). Lipid metabolism indexes TG

TC and LDL-C were significantly decreased (

0.05)

and HDL-C was increased in both groups (

0.05). The improvement of renal function indexes SCr

UAER and urine U

-MG in treatment group was significantly obvious than that in the control group (

0.05). The nailfold microcirculation results showed that the microcirculation improvement in treatment group was better than that of control group (

0.05).

Conclusion:

Tongxinluo combined with Jinlida can improve the clinical symptoms of patients with type 2 diabetic nephropathy and reduce urinary trace albumin

and its mechanism may be related to lowering glucose

regulating lipid metabolism and improving microcirculation.

关键词

Keywords

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Related Institution

School of Graduate，Hebei University of Chinese Medicine

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Hebei Yiling Hospital

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