Objective:

2

To observe the preventive and therapeutic effect of Huanglian Ejiao Tang on myocardial injury induced by anthracycline chemotherapeutic drugs in all kinds of cancer patients undergoing chemotherapy.

Method:

2

We chosen all kinds of cancer patients with combined use of anthracycline chemotherapy drugs in our hospital

21 days as one cycle. The cardiac toxicity reaction was observed after three continuous chemotherapy cycles. A total of 64 patients who met the dialectical criteria of "imbalance between heart-Yang and kidney-Yin" were randomly divided into treatment group (32 cases) and control group (32 cases). Patients in treatment group were treated with Chinese medicine Huanglian Ejiao Tang based on original chemotherapy regimen

adding and subtracting Chinese medical materials according to the symptoms. Patients in control group continued to maintain the original chemotherapy regimen

and both two groups of patients continued to receive 3 cycles of continuous chemotherapy. By comparing the cardiac function classification and cardiac function tolerance between the 3 cycles and 6 cycles of two groups of patients after chemotherapy; changes of echocardiography index

QTc interval

creatine kinase isoenzyme (CK-MB)

Myoglobin (MYO)

cardiac troponin I (cTNI)and nitrogenous terminal-pro-brain natriuretic peptide(NT-pro-BNP) concentration value were compared between two groups; and the concentrations of adrenaline (E)

norepinephrine (NE) and angiotensin Ⅱ(AngⅡ) were observed and compared; meanwhile

the correlation analysis was carried out at the same time.

Result:

2

After 6 cycles of chemotherapy in Chinese medicine treatment group

degree of cardiac function classification and the 6 minute walking heart function tolerance were significantly better than those at the 3 cycles of chemotherapy (

P

<

0.05)

but there was no significant change in control group; the concentrations of CK-MB

cTNI

MYO and NT-pro-BNP in treatment group were significantly lower than those in control group(

P

<

0.05)

and the electrocardiogram QTc interval in the treatment group was significantly lower than that in the control group (

P

<

0.05); echocardiography indexes E/A ratio and left ventricular ejective fraction (LVEF) value in the treatment group were significantly higher than those in control group (

P

<

0.05). There were no significant changes in left ventricular end-systolic diameter (LVDd) and left ventricular end-systolic diameter (LVDs) between the treatment and the control group. After 3 cycles and 6 cycles of chemotherapy

the blood NE

E and AngⅡ concentrations in the treatment group were significantly lower than those in the control group (

P

<

0.05). There were positive linear correlation in concentration changes of blood NE

E and AngⅡ as well as the concentration changes of CK-MB

cTNI

MYO and NT-pro-BNP between 3 cycles and 6 cycles after chemotherapy. After 6 cycles of chemotherapy

the incidence of cardiovascular events in the treatment group was significantly lower than that in the 3 cycles of chemotherapy

while the incidence in control group was increased.

Conclusion:

2

Huanglian Ejiao Tang can reduce the excitability of the symppthetic nervous system (SNS) and renin-angiotensin system(RAS) in human body and inhibit the release level of NE

E and AngⅡ by effect of "invigorating the kidney and clearing the heart" . It has a certain preventive and treatment effect on the cardiac toxicity of patients with the cumulative use of anthracycline chemotherapy. To a certain extent

it can inhibit myocardial injury

improve cardiac function and reduce the incidence of cardiovascular events.