Simulation of Drying Process of Single Liuwei Dihuangwan and Analysis of Its Dynamics Based on Weibull Function

Xue-cheng WANG; Chao-chao KANG; Zhen-feng WU; Ya-ru QI; Yuan-hui LI; Yong-qing YE; Ming YANG

doi:10.13422/j.cnki.syfjx.20190211

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Simulation of Drying Process of Single Liuwei Dihuangwan and Analysis of Its Dynamics Based on Weibull Function

Pharmacy and Processing | 更新时间：2021-02-09

- Simulation of Drying Process of Single Liuwei Dihuangwan and Analysis of Its Dynamics Based on Weibull Function
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 12, Pages: 133-139(2019)
- 作者机构：
  
  江西中医药大学　现代中药制剂教育部重点实验室，南昌　 330004
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190211
  CLC： R22;R94;R28;C37
- Received：10 August 2018，
  
  Published Online：03 November 2018，
  
  Published：20 June 2019
- 稿件说明：
移动端阅览
Xue-cheng WANG, Chao-chao KANG, Zhen-feng WU, et al. Simulation of Drying Process of Single Liuwei Dihuangwan and Analysis of Its Dynamics Based on Weibull Function[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(12): 133-139.
DOI：

Xue-cheng WANG, Chao-chao KANG, Zhen-feng WU, et al. Simulation of Drying Process of Single Liuwei Dihuangwan and Analysis of Its Dynamics Based on Weibull Function[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(12): 133-139. DOI： 10.13422/j.cnki.syfjx.20190211.

摘要

目的：

以单颗六味地黄丸为研究对象，探究其干燥过程水分变化及体积收缩特性，为提高丸剂干燥效率，减少丸剂干燥过程花丸、结壳、裂纹等品质问题提供实验依据。

方法：

采用恒温热风干燥及真空干燥方式研究六味地黄丸在50，75，100，125 ℃干燥温度下干燥特性，以菲克第二定律球体模型及阿伦尼乌斯方程为基础得到干燥过程水分有效扩散系数、活化能，通过投影面积法研究干燥过程中丸剂体积收缩特性，利用Weibull函数对单颗六味地黄丸干燥动力学曲线进行拟合分析。

结果：

六味地黄丸热风干燥及真空干燥均属于降速干燥过程，达到相同含水率真空干燥所需时间较热风干燥短。单颗六味地黄丸干燥过程水分比随时间变化服从Weibull函数分布(

＝0.994 5～0.999 7)，尺度参数随温度的升高而减小，干燥温度对形状参数影响显著，热风干燥及真空干燥水分有效扩散系数分别处于2.626×10

－3

～7.823×10

－2

，3.782×10

－3

～9.042×10

－2

·s

－1

，活化能分别为47.18，42.69 kJ·mol

－1

。六味地黄丸热风干燥及真空干燥体积比分别处于0.638～0.741，0.607～0.689。

结论：

Weibull函数可较好地预测六味地黄丸的干燥脱水规律，低温干燥条件下丸剂收缩速率变缓有利于防止裂丸的形成，可为六味地黄丸的干燥方式及其工艺参数选择提供理论依据。

Abstract

Objective:

Taking single Liuwei Dihuangwan(LDW) as the research object

the moisture content change and volumetric shrinkage characteristics in its drying process were investigated

which provided the theoretical basis for improving the drying efficiency of the pills and reducing the quality problems of the pattern pills

crusts and crack pills.

Method:

The drying characteristics of LDW at drying temperature of 50

100

125 ℃ were studied by constant temperature hot air drying and vacuum drying.Based on sphere model of Fick's second law and Arrhenius equation

the effective diffusion coefficient and activation energy of the drying process were obtained.The volumetric shrinkage characteristics of the pills during the drying process were studied by the projected area method.The Weibull function was used to fit the drying dynamics curve of single LDW.

Result:

Hot air drying and vacuum drying of LDW both belonged to the decreasing drying processes

and the time required to achieve the same moisture content in vacuum drying was shorter than that in hot air drying.The moisture ratio in the drying process of single LDW obeyed the Weibull function distribution(

=0.994 5-0.999 7)

the scale parameter(

) decreased with the increase of temperature

and drying temperature had significant influence on the shape parameter (

). The effective diffusion coefficients of hot air drying and vacuum drying were 2.626×10

-3

-7.823×10

-2

3.782×10

-3

-9.042×10

-2

·s

-1

their activation energy were 47.18

42.69 kJ·mol

-1

respectively.The volume ratio of hot air drying and vacuum drying of LDW ranged from 0.638 to 0.741 and 0.607 to 0.689

respectively.

Conclusion:

Weibull function can be adopted to predict the drying and dehydration law of LDW.Under the condition of low temperature drying

slow-down of shrinkage rate of the pills is helpful to prevent the formation of splitting pills

this study provides theoretical and technical basis for dying of LDW.

关键词

Keywords

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