Phenolic Components from Roots of Psidium guajava

Sheng-jia CHEN; Ying-zheng HUANG; Jian LU; Jian-qun LIU; Hui-lian HUANG; Ji-cheng SHU

doi:10.13422/j.cnki.syfjx.20190212

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Phenolic Components from Roots of Psidium guajava

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- Phenolic Components from Roots of Psidium guajava
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 2, Pages: 169-174(2019)
- 作者机构：
  
  江西中医药大学，南昌　 330004
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190212
  CLC： R284.2; R289; R22
- Received：16 January 2018，
  
  Published Online：05 November 2018，
  
  Published：20 January 2019
- 稿件说明：
移动端阅览
Sheng-jia CHEN, Ying-zheng HUANG, Jian LU, et al. Phenolic Components from Roots of Psidium guajava[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(2): 169-174.
DOI：

Sheng-jia CHEN, Ying-zheng HUANG, Jian LU, et al. Phenolic Components from Roots of Psidium guajava[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(2): 169-174. DOI： 10.13422/j.cnki.syfjx.20190212.

摘要

目的：

桃金娘科Myrrhinaceae番石榴

Psidium guajava

不同部位具有不同药用功效，其叶和果实化学成分研究深入，但有关根的化学物质基础报道甚少，为明确番石榴根的化学成分，对番石榴根进行了系统地化学成分分离与鉴定。

方法：

采用硅胶柱色谱，LH-20型羟丙基葡聚糖凝胶(Sephadex LH-20)柱色谱，大孔树脂柱色谱，反相硅胶柱色谱(ODS)及半制备高效液相色谱(HPLC)等多种色谱方法对番石榴根醇提浸膏分离纯化，应用核磁共振(NMR)和质谱，结合理化性质，鉴定化合物的结构。

结果：

从番石榴根中分离出16个酚酸类化合物，分别为3，3′，4′-三甲基鞣花酸(1)，3，3′，4-三甲基鞣花酸-4′-

-葡萄糖苷(2)，3-甲基鞣花酸-4′-

-鼠李糖苷(3)，3′-

-methyl-3，4-

，

-metheneellagic acid-4′-

-glucopyranoside(4)，没食子酸(5)，没食子酸甲酯(6)，没食子酸乙酯(7)，3，4，5-trimethoxypheny-1-

-glucopyranoside(8)，3，5-二甲氧基-4-羟基-苯甲酸-7-

-葡萄糖苷(9)，1-hydroxy-3，4，5-trimethoxyphenyl-1-

-[6′-

-(4″-carboxy-1″，3″，5″-trihydroxy)phenyl]-

-glucopyranoside(10)，香草酸(11)，原儿茶酸(12)，开环异落叶松脂素9-

-葡萄糖苷(13)，根皮素4′-

-葡萄糖苷(14)，cinchonain Ib(15)，表儿茶素(16)。

结论：

化合物3，4，6，8～10，13～15为首次从该植物中分离得到。

Abstract

Objective:

The different parts of

Psidium guajava

(Myrrhinaceae) have different bioactivities. There are intensive studies for chemical constituents of its leaves and fruits at present. However

there are a few studies for the roots. Therefore

we systematically investigated the chemical constituents of phenolic acids in roots of

guajava

Method:

The chemical constituents were isolated and purified by various column chromatography methods and semi-preparative HPLC. The isolated compounds were identified by physicochemical properties and spectral analysis.

Result:

Sixteen phenolic components were isolated from the ethanol extract and identified as 3

3′

4′-tri-

-methylellagic acid(1)

3′

4-tri-

-methylellagic acid-4′-

-glucopyranoside(2)

-methylellagic acid-4′-

-rhamnopyranoside(3)

3′-

-methyl-3

-metheneellagic acid-4′-

-glucopyranoside(4)

gallic acid(5)

methyl gallate(6)

ethyl gallate(7)

5-trimethoxypheny-1-

-glucopyranoside(8)

5-dimethoxy-4-hydroxy-benzoic acid-7-

-glucoside(9)

1-hydroxy-3

5-trimethoxyphenyl-1-

-[6′-

-(4″-carboxy-1″

3″

5″-trihydroxy)phenyl]-

-glucopyranoside(10)

vanillic acid(11)

protocatechuic acid(12)

secoisolariciresinol 9-

-glucopyranoside(13)

phloretin 4′-

-glucopyranoside(14)

cinchonain Ib(15) and epicatechin(16).

Conclusion:

Compounds 3

8-10

13-15 were isolated from this plant for the first time.

关键词

Keywords

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