Comparison of in Vitro Dissolution of Active Ingredients in Gastrodiae Rhizoma Powder with Different Particle Size

Fan LIU; Ting-ting CHEN; Yan CHEN; Zi-peng GONG; Zhi LIU; Ai-min WANG

doi:10.13422/j.cnki.syfjx.20190305

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Comparison of in Vitro Dissolution of Active Ingredients in Gastrodiae Rhizoma Powder with Different Particle Size

Pharmacy and Processing | 更新时间：2021-02-09

- Comparison of in Vitro Dissolution of Active Ingredients in Gastrodiae Rhizoma Powder with Different Particle Size
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 9, Pages: 124-129(2019)
- 作者机构：
  
  1.贵州医科大学　贵州省药物制剂重点实验室，省部共建药用植物功效与利用国家重点实验室，民族药与中药开发应用教育部工程研究中心，药学院，贵阳　 550004
  2.贵州医科大学　附属医院，贵阳　 550004
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190305
  CLC： R22; R24; R28; C37; R94
- Received：20 August 2018，
  
  Published Online：16 November 2018，
  
  Published：05 May 2019
- 稿件说明：
移动端阅览
Fan LIU, Ting-ting CHEN, Yan CHEN, et al. Comparison of in Vitro Dissolution of Active Ingredients in Gastrodiae Rhizoma Powder with Different Particle Size[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(9): 124-129.
DOI：

Fan LIU, Ting-ting CHEN, Yan CHEN, et al. Comparison of in Vitro Dissolution of Active Ingredients in Gastrodiae Rhizoma Powder with Different Particle Size[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(9): 124-129. DOI： 10.13422/j.cnki.syfjx.20190305.

摘要

目的：

研究不同粒径天麻粉末中有效成分(天麻素，对羟基苯甲醇，巴利森苷A，巴利森苷B，巴利森苷C)的体外溶出行为差异，为天麻超微粉的应用提供实验依据。

方法：

采用桨法对天麻粉末在不同溶出介质(水、人工胃液、人工肠液)中溶出度进行测定，利用HPLC测定不同粒径天麻粉中上述5种有效成分的溶出度，流动相乙腈-0.1%磷酸水溶液梯度洗脱，柱温40 ℃，检测波长220 nm。

结果：

在水中、人工肠液介质中，天麻细粉、极细粉中5种有效成分的溶出速率较天麻3种超微粉低；在人工胃液中，天麻超微粉中天麻素和对羟基苯甲醇的溶出速率较其他粉体高，但天麻超微粉中巴利森苷A的溶出速率较其他粉体低。

结论：

适度的微粉化能促进天麻粉末中有效成分的溶出，并不是越细越好，有效成分的溶出行为还受溶出介质的影响，可为天麻粉末临床应用时选择最佳粒径提供实验依据。

Abstract

Objective:

To compare

in vitro

dissolution behaviors of active ingredients(gastrodin

parishin A

-hydroxybenzyl alcohol

parishin B and parishin C) in Gastrodiae Rhizoma powder with different particle size.

Method:

In vitro

dissolution of Gastrodiae Rhizoma powder in different dissolution media(water

artificial gastric juice and artificial intestinal juice) were detected by stirring paddle method.Dissolution of these five components in Gastrodiae Rhizoma powder with different particle size was determined by HPLC

mobile phase was acetonitrile-0.1%phosphoric acid solution for gradient elution

column temperature was set at 40 ℃ and detection wavelength was 220 nm.

Result:

In water and artificial intestinal juice

the dissolution rates of five active components in three kinds of Gastrodiae Rhizoma ultrafine powders were higher than that of the fine powder and the finest powder; in artificial gastric juice

the dissolution rates of gastrodin and

-hydroxybenzyl alcohol in Gastrodiae Rhizoma ultrafine powders were higher than that of the other powders

and the dissolution rate of parishin A in Gastrodiae Rhizoma ultrafine powders was lower than that of the other powders.

Conclusion:

An appropriate degree of superfine grinding can promote the dissolution of active ingredients in Gastrodiae Rhizoma

but not as fine as possible.The dissolution medium has an obvious influence on the dissolution behaviors of active components

which provides a reference for screening optical particle size of Gastrodiae Rhizoma powder in clinical application.

关键词

Keywords

references

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