Objective:

2

To observe effect of method of regulating Qi to dissipate blood stasis and phlegm on degree of heart failure

ventricular remodeling

disease progression in patients with Qi deficiency and blood stasis type chronic heart failure (CHF).

Method:

2

One hundred and thirty-four patients with CHF were randomly divided into control group (62 cases) and observation group (62 cases) by random number table. The patients in control group got spironolactone tablets

20 mg/time and

qd

. Benazepril

20 mg/time and

qd

. Bisoprolol

10 mg/time and

qd

. And digaoxin tablets if necessary. Based on the treatment in control group

patients in observation group additionally received Danshenyin and Xuefu Zhuyutang

1 dose/day. The treatment course was 3 months in both groups. Before and after treatment

scores of Lee heart failure score were graded

cardiac function classification of the New York Heart Association (NYHA)

6 mins' walking test (6 MWT)

scores of Qi deficiency and blood stasis and Minnesota living with heart failure questionnaire (MLHFQ) were evaluated. Echocardiography

left ventricular ejection fraction (LVEF)

Left ventricular end-diastolic diameter (LVEDd)

left ventricular end-stolic diameter (LVEDs)

interventricular septum thickness at end-diastole (IVSd) and left ventricular myocardial mass index (LVMI) were recorded. Levels of matrix metalloprotein-9 (MMP-9)

tissue inhibitor of matrix metalloprotease-1 (TIMP-1)

transforming growth factor-

β

1

(TGF-

β

1

)

N

-terminal pro-B-type na-triuretic peptide (NT-proBNP)

galectin-3 and copeptin were detected.

Result:

2

Ridit analysis showed that after treatment

effect on cardiac function in observation group was better than that in control group (

P

<

0.05). Classification of cardiac function of NYHA was lower than that in control group (

P

<

0.05). The LVEDd

LVEDs and LVMI in observation group were all less than those in control group (

P

<

0.05)

while LVEF was higher than that in control group (

P

<

0.05). There was no statistically significant difference in IVSd between two groups. Scores of Lee heart failure score

MLHFQ and Qi deficiency and blood stasis in observation group were lower than those in control group

and distance of 6 mins' walking was larger than that in control group (

P

<

0.01). Levels of serum MMP-9

TGF-

β

1

NT-proBNP

galectin-3 and copeptin in observation group were lower than those in control group

while level of TIMP-1 was higher than that in control group (

P

<

0.01).

Conclusion:

2

Based on the routine western medicine treatment

additional Danshenyin and Xuefu Zhuyutang can ameliorate symptoms of heart failure

relieve degree of heart failure

improve exercise tolerance and quality of life

inhibit ventricular remodeling

improve cardiac rehabilitation and delay progress of the disease for the CHF patients with Qi deficiency and blood stasis.