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Chemical Constituents and Pharmacological Effect of Lonicerae Japonicae Flos
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 4, Pages: 225-234(2019)
- 作者机构：
1.新乡医学院 药学院，河南 新乡 453003；
2.新乡医学院 医学检验学院，河南 新乡 453003
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20190408
CLC： R2-0;R22;R284;R285.5Received：19 July 2018，
Published Online：06 November 2018，
Published：20 February 2019
- 稿件说明：
移动端阅览
Jiao WU, Cong WANG, Hai-chuan YU. Chemical Constituents and Pharmacological Effect of Lonicerae Japonicae Flos[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(4): 225-234.
Jiao WU, Cong WANG, Hai-chuan YU. Chemical Constituents and Pharmacological Effect of Lonicerae Japonicae Flos[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(4): 225-234. DOI： 10.13422/j.cnki.syfjx.20190408.
摘要
金银花是一种具有悠久历史的常用中药，具有清热解毒、宣散风热的功效，集中分布于河南、山东、广东等地。金银花的化学成分主要包括有机酸类、黄酮类、环烯醚萜苷类、三萜皂苷类、挥发油类以及其他各种成分。金银花的药理作用主要为抗炎解热，抗肿瘤，抗菌抗病毒，抗衰老抗氧化，降低血糖，保肝，保护肺脏，神经保护作用，增强机体免疫功能以及抗血小板聚集等。因其具有丰富的药理作用，药用价值高，常可与多种其他药物配伍用于多种方剂之中，临床应用广泛，社会需求量大。本文通过查阅近几年金银花的化学成分及其药理作用方面的相关文献，了解到多名学者对其进行研究并从金银花中首次分离得到多种新的化学成分且对金银花的药理作用机制进了详细研究，因此通过整理相关研究结果，对其进行归纳总结，为更多人认识并了解金银花的最新研究进展提供参考，也可为金银花的开发利用提供科学依据。
Abstract
Lonicerae Japonicae Flos is a commonly used traditional Chinese medicine with a long history. It has the functions of detoxification
heat dissipation and heat dissipation
with a high medicinal value. It is mainly distributed in Henan
Shandong
Guangdong and other places. Researches have shown that the chemical constituents of honeysuckle mainly include organic acids
flavonoids
iridoid glycosides
three terpenoid glycosides
three terpenoid glycosides and volatile oils. And the pharmacological effects of honeysuckle are mainly anti-inflammation and antipyretic
anti-tumor
anti-bacteria
anti-virus
anti-aging and anti-oxidation
lowering blood sugar
protecting liver
protecting lung
neuroprotective
enhancing immune function and anti-platelet aggregation. Because of its rich pharmacological effects and high medicinal value
it has been used in a variety of prescriptions
with wide clinical applications and its large social demands. In this paper
we have reviewed the literatures on the chemical constituents and pharmacological effects of honeysuckle in recent years
and learned that many scholars have studied it
isolated a variety of new chemical components from honeysuckle for the first time and studied the pharmacological effects of honeysuckle in detail. In this paper
we reviewed the research progress of chemical constituents and pharmacological effects of Lonicerae Japonicae Flos
providing references for more people to learn related knowledge of honeysuckle and a scientific basis for the development and utilization of Lonicerae Japonicae Flos.
关键词
Keywords
references
岳路路 ， 高敏 ， 张秋红 ， 等 . 复方黄柏液体外抗病毒试验初步研究 [J]. 辽宁中医药大学学报 ， 2016 , 18 ( 11 ): 20 - 22 .
LIU Q , LIU S , GAO L , et al . Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KK(Ay) mice [J]. Acta Pharm Sin B , 2017 , 7 ( 4 ): 461 - 469 .
倪付勇 ， 温建辉 ， 李明 ， 等 . 金银花化学成分研究 [J]. 中草药 ， 2017 , 48 ( 18 ): 3689 - 3692 .
王旭 ， 周洪雷 ， 容蓉 . 金银花化学成分研究 [J]. 中药材 ， 2016 , 39 ( 9 ): 2030 - 2032 .
JIANG N H . Study on Chemical Constituents of Lonicera japonica Bud [J]. Chin Tradit Herb Drugs , 2015 , 38 ( 2 ): 315 - 317 .
NI F Y , LIU L , SONG Y L , et al . Anti-complementary phenolic acids from Lonicera japonica [J]. China J Chin Mater Med , 2015 , 40 ( 2 ): 269 - 74 .
LIU Z , CHENG Z , HE Q , et al . Secondary metabolites from the flower buds of Lonicera japonica and their in vitro anti-diabetic activities [J]. Fitoterapia , 2016 , 110 : 44 - 51 .
Lo I W , CHENG Y B , Hsieh Y J , et al . Chemical constituents and LC-profile of fresh formosan Lonicera japonica flower buds [J]. Nat Prod Commun , 2016 , 11 ( 1 ): 1 - 4 .
WANG F , JIANG Y P , WANG X L , et al . Chemical constituents from flower buds of Lonicera japonica [J]. China J Chin Mater Med , 2013 , 38 ( 9 ): 1378 - 1385 .
LI H B , YU Y , MEI Y D , et al . A new hetero dimeric terpenoid derivative, japonicaside C, from the flower buds of Lonicera japonica [J]. Nat Prod Res , 2017 , 31 ( 2 ): 143 - 148 .
李泮霖 ， 李楚源 ， 刘孟华 ， 等 . 基于 UF LC-Triple-Q-TOF-MS/MS技术的金银花、山银花化学成分比较 [J]. 中南药学 ， 2016 , 14 ( 4 ): 363 - 369 .
李畅 ， 戴毅 ， 张金博 ， 等 . 金银花中1个新的环烯醚萜苷类化合物 [J]. 中草药 ， 2013 , 44 ( 21 ): 2951 - 2954 .
YANG B , MENG Z , MA Y , et al . One New Conjugate of a Secoiridoid Glucoside with a Sesquiterpene Glucoside from the Flower Buds of Lonicera japonica [J]. Nat Prod Commun , 2015 , 10 ( 9 ): 1499 - 1500 .
GE W , LI H B , FANG H , et al . A new dimeric secoiridoids derivative, japonicaside E, from the flower buds of Lonicera japonica [J]. Nat Prod Res , 2018 , 3 : 1 - 6 .
YU Y , SONG W X , GUO Q L , et al . Studies on chemical constituents of aqueous extract of Lonicera japonica flower buds [J]. China J Chin Mater Med , 2015 , 40 ( 17 ): 3496 - 3504 .
YANG J , LI Y C , ZHOU X R , et al . Two thymol derivatives from the flower buds of Lonicera japonica and their antibacterial activity [J]. Nat Prod Res , 2017 : 1 - 6 .
YU Y , ZHU C , WANG S , et al . Homosecoiridoid alkaloids with amino acid units from the flower buds of Lonicera japonica [J]. J Nat Prod , 2013 , 76 ( 12 ): 2226 - 2233 .
WANG F , JIANG Y P , WANG X L , et al . Aromatic glycosides from the flower buds of Lonicera japonica [J]. J Asian Nat Prod Res , 2013 , 15 ( 5 ): 492 - 501 .
冯秀丽 ， 许庆华 ， 赵晓云 ， 等 . 金银花及其复方的体外抑菌活性与体内抗炎作用 [J]. 沈阳药科大学学报 ， 2013 , 30 ( 1 ): 35 - 39,62 .
Kwon S H , MA S X , HONG S I , et al . Lonicera japonica THUNB. extract inhibits lipopolysaccharide-stimulated inflammatory responses by suppressing NF-kappaB signaling in BV-2 microglial cells [J]. J Med Food , 2015 , 18 ( 7 ): 762 - 775 .
王亚琼 ， 陈卫 ， 钟水生 ， 等 . 金银花清热解毒作用的血清代谢组学研究 [J]. 中药材 ， 2016 , 39 ( 5 ): 1129 - 1133 .
Park J W , Bae H , Lee G , et al . Prophylactic effects of Lonicera japonica extract on dextran sulphate sodium-induced colitis in a mouse model by the inhibition of the Th1/Th17 response [J]. Br J Nutr , 2013 , 109 ( 2 ): 283 - 292 .
HONG S H , Kwon J T , Shin J Y , et al . Therapeutic effect of Broussonetia papyrifera and Lonicera japonica in ovalbumin-induced murine asthma model [J]. Nat Prod Commun , 2013 , 8 ( 11 ): 1609 - 1614 .
杜江 . 金银花主要成分绿原酸对RSV感染RAW264.7细胞的TLR3信号通路的影响 [J]. 齐齐哈尔医学院学报 ， 2017 , 38 ( 6 ): 626 - 628 .
Lee Y R , Yeh S F , RUAN X M , et al . Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis [J]. J Ethnopharmacol , 2017 , 198 : 109 - 121 .
朱琳枫 ， 鲍欣欣 ， 姚辉 ， 等 ． 金银花和鱼腥草抑制甲型流感病毒体外复制研究 [J]. 国际检验医学杂志 ， 2018 , 39 ( 4 ): 485 - 486 .
胡燕敏 ， 周爱梅 ， 宋倩 ， 等 . 4种中草药提取液的工艺优化及其抗菌效果对比 [J]. 食品安全质量检测学报 ， 2017 , 8 ( 8 ): 3169 - 3176 .
赵蓓蓓 ， 赵晶 ， 王志铮 ， 等 . 10种常见中草药水提物对嗜水气单胞菌ZHYYZ-1的体外抑菌效果研究 [J]. 浙江海洋学院学报：自然科学版 ， 2012 , 31 ( 4 ): 316 - 320 .
李黎 ， 孙晶 . 多倍体金银花与二倍体金银花不同部位提取物的抑菌作用及绿原酸含量的比较研究 [J]. 食品科技 ， 2012 , 37 ( 8 ): 225 - 227,231 .
YANG L , Aguilar Z P , QU F , et al . Enhanced antimicrobial activity of silver nanoparticles-Lonicera japonica Thunb combo [J]. IET Nanobiotechnol , 2016 , 10 ( 1 ): 28 - 32 .
朱小峰 ， 朱晓娣 ， 王金梅 ． 封丘产金银花不同提取物的体外抗氧化、抗凝血及α-葡萄糖苷酶抑制活性研究 [J]. 中国药房 ， 2016 , 27 ( 34 ): 4804 - 4806 .
田磊 ， 蒋宝平 ， 何苗 ， 等 ． 金银花-山银花水提液不同配比体外抗氧化作用研究 [J]. 实用药物与临床 ， 2014 , 17 ( 10 ): 1290 - 1294 .
WANG C , WANG G , LIU H , et al . Protective effect of bioactive compounds from Lonicera japonica Thunb. against H 2 O 2 -induced cytotoxicity using neonatal rat cardiomyocytes [J]. Iran J Basic Med Sci , 2016 , 19 ( 1 ): 97 - 105 .
WANG F , MIAO M , XIA H , et al . Antioxidant activities of aqueous extracts from 12 Chinese edible flowers in vitro and in vivo [J]. Food Nutr Res , 2017 , 61 ( 1 ): e1265324 .
YANG Z Z , YU Y T , LIN H R , et al . Lonicera japonica extends lifespan and healthspan in Caenorhabditis elegans [J]. Free Radic Biol Med , 2018 , 129 : 310 - 322 .
Park C , Lee W S , HAN M H , et al . Lonicera japonica Thunb. induces caspase-dependent apoptosis through death receptors and suppression of AKT in U937 human leukemic cells [J]. Phytother Res , 2018 , 32 ( 3 ): 504 - 513 .
Park K I , Park H , Nagappan A , et al . Polyphenolic compounds from Korean Lonicera japonica Thunb. induces apoptosis via Akt and caspase cascade activation in A549 cells [J]. Oncol Lett , 2017 , 13 ( 4 ): 2521 - 2530 .
ZHOU Y , DING B Z , LIN Y P , et al . MiR-34a, as a suppressor, enhance the susceptibility of gastric cancer cell to luteolin by directly targeting HK1 [J]. Gene , 2018 , 644 : 56 - 65 .
YU J K , YUE C H , PAN Y R , et al . Isochlorogenic acid C reverses epithelial-mesenchymal transition via down-regulation of EGFR pathway in MDA-MB-231 cells [J]. Anticancer Res , 2018 , 38 ( 4 ): 2127 - 2135 .
HAN X L , LI J D , WANG W L , et al . Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis [J]. Biomed Pharmacother , 2017 , 95 : 477 - 486 .
王东升 . 金银花提取物对肝损伤小鼠的保护作用研究 [J]. 医学导报 ， 2011 , 30 ( 8 ): 1010 - 1012 .
Tzeng T F , Tzeng Y C , CHENG Y J , et al . The Ethanol Extract from Lonicera japonica Thunb. regresses nonalcoholic steatohepatitis in a methionine-and choline-deficient diet-fed animal model [J]. Nutrients , 2015 , 7 ( 10 ): 8670 - 8684 .
Park Y C , JIN M , Kim S H , et al . Effects of inhalable microparticle of flower of Lonicera japonica in a mouse model of COPD [J]. J Ethnopharmacol , 2014 , 151 ( 1 ): 123 - 130 .
王强 ， 陈东辉 ， 邓文龙 . 金银花提取物对血脂与血糖的影响 [J]. 中药药理与临床 ， 2007 , 23 ( 3 ): 40 - 42 .
WANG D , ZHAO X , LIU Y. Hypoglycemic and hypolipidemic effects of a polysaccharide from flower buds of Lonicera japonica in streptozotocin-induced diabetic rats [J]. Int J Biol Macromol , 2017 , 102 : 396 - 404 .
MIAO M , CAO L , LI R , et al . Protective effect of chlorogenic acid on the focal cerebral ischemia reperfusion rat models [J]. Saudi Pharm J , 2017 , 25 ( 4 ): 556 - 563 .
SU D , LI S , ZHANG W , et al . Structural elucidation of a polysaccharide from Lonicera japonica flowers, and its neuroprotective effect on cerebral ischemia-reperfusion injury in rat [J]. Int J Biol Macromol , 2017 , 99 : 350 - 357 .
Park S , Kang S , Kim D S , et al . Agrimonia pilosa Ledeb., Cinnamomum cassia Blume, and Lonicera japonica Thunb. protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance in beta-amyloid-infused rats [J]. Nutr Neurosci , 2017 , 20 ( 2 ): 77 - 88 .
WANG R , SUN Y , HUANG H , et al . Rutin, a natural flavonoid protects PC12 cells against sodium nitroprusside-induced neurotoxicity through activating PI3K/Akt/mTOR and ERK1/2 pathway [J]. Neurochem Res , 2015 , 40 ( 9 ): 1945 - 1953 .
王妍 ， 石学魁 ， 宋宝 . 金银花增强小鼠免疫功能的研究 [J]. 牡丹江医学院学报 ， 2010 , 31 ( 2 ): 49 - 50 .
周秀萍 ， 李争鸣 ， 刘志杰 ， 等 . 金银花对大鼠免疫功能影响的研究 [J]. 实用预防医学 ， 2011 , 18 ( 2 ): 214 - 216 .
PI J H , TAN J , HU Z T , et al . Effects of Lonicera Japonica flavone on immunomodulation in mice [J]. Chin J Appl Physiol , 2015 , 31 ( 1 ): 89 - 92 .
Kim S J , Kim J S , Choi H S , et al . HS-23, a Lonicera japonica extract, reverses sepsis-induced immunosuppression by inhibiting lymphocyte apoptosis [J]. J Ethnopharmacol , 2015 , 171 : 231 - 239 .
ZHOU X , DONG Q , KAN X , et al . Immunomodulatory activity of a novel polysaccharide from Lonicera japonica in immunosuppressed mice induced by cyclophosphamide [J]. PLoS One , 2018 , 13 ( 10 ): e0204152 .
LU X , WO G , LI B , et al . The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-kappaB/IL-6/STAT3 signaling in hepatocellular carcinoma [J]. Biomed Pharmacother , 2018 , 102 : 420 - 427 .
梁添奇 ， 唐丽君 ， 黄为民 . 茵栀黄口服液与金银花提取物对葡萄糖-6-磷酸脱氢酶缺乏大鼠的溶血影响及退黄疗效分析 [J]. 中国当代儿科杂志 ， 2018 , 20 ( 9 ): 769 - 774 .
王芳 ， 黄超培 ， 李彬 ， 等 ． 复方蜂胶金银花提取物对炎症大鼠和小鼠的抗炎作用 [J]. 广西医学 ， 2018 , 40 ( 16 ): 1833 - 1836 .
王碧成 ， 杨德兴 ， 吴杰 ， 等 ． 双黄连与利多卡因抗乌头碱诱发大鼠心律失常的疗效对比 [J]. 昆明医科大学学报 ， 2014 , 35 ( 6 ): 33 - 36 .
梁德东 ， 马钦海 ， 于青田 ， 等 ． 银翘马勃散对急性咽炎模型大鼠的治疗作用及其抗炎镇痛解热的作用 [J]. 中药药理与临床 ， 2017 , 33 ( 3 ): 8 - 11 .
刘玉婕 ， 王长福 ， 齐彦 ， 等 . 金银花、连翘及其配伍后对临床11种致病菌的作用研究 [J]. 中医药学报 ， 2016 , 44 ( 5 ): 43 - 47 .
李海志 ， 徐旖旎 ， 赵玲璐 ， 等 ． 复方对乙酰氨基酚金银花胶囊的抗炎镇痛解热作用 [J]. 贵州医科大学学报 ， 2017 , 42 ( 5 ): 523 - 527 .
杨倩茹 ， 赵媛媛 ， 郝江波 ， 等 ． 金银花与山银花化学成分及其差异的研究进展 [J]. 中国中药杂志 ， 2016 , 41 ( 7 ): 1204 - 1211 .
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