Clinical Efficacy of Duhuo Xuduan Tang in Treatment of Lumbar Disc Herniation

Zhi-guang WANG; Yan-hui SHANG; Tao TAN; Bing RONG

doi:10.13422/j.cnki.syfjx.20190427

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Clinical Efficacy of Duhuo Xuduan Tang in Treatment of Lumbar Disc Herniation

Classic Prescriptions | 更新时间：2021-02-09

- Clinical Efficacy of Duhuo Xuduan Tang in Treatment of Lumbar Disc Herniation
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 4, Pages: 63-69(2019)
- 作者机构：
  
  1.天津中医药大学　第一附属医院，天津　 300193；
  2.天津中医药大学　附属武清中医医院，天津　 301700
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190427
  CLC： R22;R242;R2-031;R287
- Received：31 August 2018，
  
  Published Online：05 November 2018，
  
  Published：20 February 2019
- 稿件说明：
移动端阅览
Zhi-guang WANG, Yan-hui SHANG, Tao TAN, et al. Clinical Efficacy of Duhuo Xuduan Tang in Treatment of Lumbar Disc Herniation[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(4): 63-69.
DOI：

Zhi-guang WANG, Yan-hui SHANG, Tao TAN, et al. Clinical Efficacy of Duhuo Xuduan Tang in Treatment of Lumbar Disc Herniation[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(4): 63-69. DOI： 10.13422/j.cnki.syfjx.20190427.

摘要

目的：

探讨独活续断汤治疗不同证型腰间盘突出症的临床疗效，对生活能力，血清疼痛因子，骨形成蛋白-7(BMP-7)，聚集蛋白聚糖(Aggrecan)的影响。

方法：

将2017年1月至2018年6月天津中医药大学第一附属医院收治的非急症期腰间盘突出症患者121例随机分为观察组(62例)和对照组(59例)，两组患者均给予复位手法治疗后绝对卧床休息，观察组给予独活续断汤治疗，150 mL/次，3次/d口服，对照组给予布洛芬300 mg/次、维生素B

10 mg/次，2次/d口服，每周服药5 d，停药2 d，两组患者均连续治疗4周，观察两组患者治疗前后视觉模拟评分(VAS)，改良Oswestry功能障碍指数变化；酶联免疫吸附测定(ELISA)检测治疗前后血清P物质(SP)，多巴胺(DA)，五羟色胺(5-HT)，BMP-7及Aggrecan含量变化。

结果：

与本组治疗前比较，两组患者VAS，改良Oswestry功能障碍指数评分均降低(

0.01)，血清BMP-7，Aggrecan含量升高，SP，DA，5-HT含量降低(

0.01)；与对照组治疗后比较，观察组患者VAS，改良Oswestry功能障碍指数评分均降低(

0.01)，临床疗效提高(

0.01)，血清BMP-7，Aggrecan含量更高，SP，DA及5-HT含量更低(

0.01)；在所有证型中肝肾阴虚型患者疗效最佳。

结论：

独活续断汤对不同类型腰间盘突出症均有一定疗效，但对于肝肾阴虚型患者疗效最佳。

Abstract

Objective:

To investigate clinical efficacy of Duhuo Xuduan Tang in treatment of lumbar disc herniation with different syndrome types and its effect on serum pain factors

bone morphogenetic protein-7 (BMP-7) and Aggrecan.

Method:

A total of 121 patients with non-emergency lumbar disc herniation admitted to the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from January 2017 to June 2018 were randomly divided into observation group (62 cases) and control group (59 cases). The two groups of patients were treated by repositioning maneuver before absolute bed rest. observation group was given Duhuo Xuduan Tang

150 mL·time

-1

3 times·d

-1

orally

while control group was orally given ibuprofen

300 mg·time

-1

vitamin B

10 mg·time

-1

2 times·d

-1

drugs were taken for 5 days a week

and then stopped for 2 days. Both groups were treated continuously for 4 weeks. changes in visual analogue score (VAS)

modified Oswestry dysfunction index (MODI)

serum substance P (SP)

dopamine (DA)

serotonin (5-HT)

BMP-7 and Aggrecan were observed before and after treatment with enzyme-linked immunosandwich assay (ELISA).

Result:

Compared with before treatment

VAS and modified Oswestry dysfunction index scores were lower in both groups (

0.05)

BMP-7 and Aggrecan contents were higher

while SP

DA and 5-HT contents were lower (

0.05). Compared with control group

VAS and modified Oswestry dysfunction index scores of observation group were lower (

0.05)

clinical efficacy was improved (

0.05)

levels of BMP-7 and Aggrecan in serum were higher

whereas contents of SP

DA and 5-HT were lower (

0.05).

Conclusion:

Duhuo Xuduan Tang has a certain efficacy on different types of lumbar disc herniation

with best efficacy for patients with liver and kidney yin deficiency.

关键词

Keywords

references

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