Mechanism of External Use of Traditional Chinese Medicine—" Three Micro- Regulations for Balance" Based on Neural-endocrine-immune Network

Shuo TIAN; Ming-san MIAO

doi:10.13422/j.cnki.syfjx.20190436

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Mechanism of External Use of Traditional Chinese Medicine—" Three Micro- Regulations for Balance" Based on Neural-endocrine-immune Network

Topical Study of TCM for External Use | 更新时间：2021-02-09

- Mechanism of External Use of Traditional Chinese Medicine—" Three Micro- Regulations for Balance" Based on Neural-endocrine-immune Network
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 4, Pages: 6-12(2019)
- 作者机构：
  
  河南中医药大学，郑州　 450046
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190436
  CLC： G353.11;R26;R285.5;R392.6
- Received：23 September 2018，
  
  Published Online：08 November 2018，
  
  Published：20 February 2019
- 稿件说明：
移动端阅览
Shuo TIAN, Ming-san MIAO. Mechanism of External Use of Traditional Chinese Medicine—" Three Micro- Regulations for Balance" Based on Neural-endocrine-immune Network[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(4): 6-12.
DOI：

Shuo TIAN, Ming-san MIAO. Mechanism of External Use of Traditional Chinese Medicine—" Three Micro- Regulations for Balance" Based on Neural-endocrine-immune Network[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(4): 6-12. DOI： 10.13422/j.cnki.syfjx.20190436.

摘要

中药(TCM)外治法是目前所知起源最早的治疗疾病方法，起源于先秦，成长于汉唐，创新于宋元，发展于明清，为人类的健康事业做出卓越贡献。现代药源性疾病的大幅攀升，药物外治因其不良反应小、应用方便、疗效确切等，受到了国内外广泛关注。随着中药外用药物、剂型、方法等的增多，中药临床应用范围不断扩大，已广泛应用到儿科、妇科、内科、肿瘤科等，但多无用量、用法、用药时间、疗程等的规范，随意性较大。中药外用治疗局部病变，可以在局部发挥直接的作用。中药外用多以“外治之理即内治之理”来阐述外用机制，以内服功能只能从中医理论部分阐述其外治特点，多不能很好指导相应中药临床外用。对于中药外用机制鲜有现代研究的报道，多是从理论到理论的论述，缺少现代研究的证实和支撑。也有散在的中药外用透皮吸收相关报道，但中药外用多为打粉、水煎、醇提等粗制剂，剂量、剂型、疗程、外用方法等多随意性大，加之成分复杂、含量较低等，单纯从透皮吸收很难阐述其外用的机制，也不符合中药临床应用的事实，外用机制的不明确，限制了中药外用的发展。本文通过前期大量的文献研究、数据库研究、实验研究等，提出了中药外用通过局部微作用、微刺激、微吸收，即“三微调平衡”，调整神经-内分泌-免疫网络的紊乱，而发挥外用疗效，从而达到治疗疾病的目的。

Abstract

The external treatment of traditional Chinese medicine(TCM) is the earliest known treatment method for diseases. It originated in pre-Qin dynasty

grew up in Han and Tang dynasties

innovated in Song and Yuan dynasties

and developed in Ming and Qing dynasties. It has made outstanding contributions to the human health.With the rapid rise of modern drug-derived diseases

the external treatment of drugs has attracted wide attention at home and abroad due to its small adverse reactions

convenient application and accurate curative effect. With the increasing of TCM for external use drugs

dosage form

method

the clinical application of TCM has been expanding unceasingly

it has been widely applied to the pediatric

gynecological

internal medicine

oncology

however

there has not many specifications for amount

usage

time

and course of treatment

which are more arbitrary. Topical use of TCM can play a direct role in the treatment of local lesions. The external use of TCM is mainly explained by " the principle of external treatment is the principle of internal treatment"

and the internal use function can only be explained from the theoretical part of TCM on its external treatment characteristics

and most can not well guide the corresponding clinical application of TCM. There are few reports on the mechanism of external use of TCM

and most of them are from theory to theory

lacking the confirmation and support of modern studies. There are also related reports on transdermal absorption of scattered TCM for external use. However

most of the external use of TCM are crude preparations such as pulverising

decocting in water and alcohol extraction

and its more random which the dose

dosage type

course of treatment

external use methods

coupled with its complex ingredients and low content

it is difficult to explain the mechanism of external use simply from transdermal absorption

nor does it meet the facts of clinical application of TCM. The mechanism of external use is not clear

and restricted the development of TCM for external use. This article through the extensive experimental research

literature research and database research

and proposed that TCM for external use through adjustment of neural-endocrine-immune network disorders

through local micro effect

micro stimulation

micro absorption

that's the " three fine tuning balances"

and exert external use curative effect

so as to achieve the purpose of treating diseases.

关键词

Keywords

references

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