Research on Differential Feature Elements and Characteristic Spectrum of Inorganic Elements Between Calcined Alumen and Its Counterfeit Processed Products Based on ICP-OES/ICP-MS

Sheng-jin LIU; Ting-ting QIAO; Yu-lu MA; Fang FANG; Rui-chao LIN; Min-jie BAO; Yao CHEN; De-kang WU

doi:10.13422/j.cnki.syfjx.20190511

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Research on Differential Feature Elements and Characteristic Spectrum of Inorganic Elements Between Calcined Alumen and Its Counterfeit Processed Products Based on ICP-OES/ICP-MS

Topic on Mineral Medicines | 更新时间：2021-02-09

- Research on Differential Feature Elements and Characteristic Spectrum of Inorganic Elements Between Calcined Alumen and Its Counterfeit Processed Products Based on ICP-OES/ICP-MS
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 5, Pages: 1-7(2019)
- 作者机构：
  
  1.南京中医药大学　江苏省中药资源产业化过程协同创新中心，中药资源产业化与方剂创新药物国家地方联合工程研究中心，国家中医药管理局中药资源循环利用重点研究室，江苏省中药功效物质重点实验室，南京　 210023；
  2.北京中医药大学，北京　 100029
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190511
  CLC： R284.1;R22;R2-03;R289
- Received：06 April 2018，
  
  Published Online：21 November 2018，
  
  Published：05 March 2019
- 稿件说明：
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Sheng-jin LIU, Ting-ting QIAO, Yu-lu MA, et al. Research on Differential Feature Elements and Characteristic Spectrum of Inorganic Elements Between Calcined Alumen and Its Counterfeit Processed Products Based on ICP-OES/ICP-MS[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(5): 1-7.
DOI：

Sheng-jin LIU, Ting-ting QIAO, Yu-lu MA, et al. Research on Differential Feature Elements and Characteristic Spectrum of Inorganic Elements Between Calcined Alumen and Its Counterfeit Processed Products Based on ICP-OES/ICP-MS[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(5): 1-7. DOI： 10.13422/j.cnki.syfjx.20190511.

摘要

目的：

分析临床用枯矾及其伪品铵明矾炮制品的差异无机元素，并建立其特征图谱，为枯矾提供新的质量控制手段。

方法：

应用ICP-OES及ICP-MS测定枯矾和铵明矾炮制品中22种无机元素的含量，采用SPSS 16.0软件对原始数据进行分层聚类分析，以SIMCA-P 13.0软件配合

检验及秩和检验对差异性无机元素进行识别，建立枯矾与伪品的无机元素特征谱。

结果：

枯矾中主含K

Al等元素，伪品主含Al

Fe等元素；枯矾Cr

Mn含量相对较高，铵明矾炮制品Mn

Ga含量相对较高。其中枯矾中K元素含量约为伪品的205倍；相反，Fe

Ga等元素，伪品的平均含量远高于枯矾，分别约为枯矾平均含量的33，46，38，27倍。聚类分析将18个样品聚类为枯矾和铵明矾炮制品两大类。共筛选出18种含量具有显著性差异(

0.05)的元素，分别为Be

Pb。建立了枯矾、伪品枯矾含21种无机元素特征谱。

结论：

该分析方法可用于枯矾的质量控制。

Abstract

Objective:

To provide the new quality control means for Alumen by investigating the elemental differences between calcined Alumen and its counterfeit processed products of ammonium alum

and establishing their characteristic chromatogram.

Method:

The contents of 22 inorganic elements both in calcined Alumen and processed products of ammonium alum were determined by means of inductively coupled plasma (ICP)-optical emission spectrometer-mass spectrometry (ICP-OES/ICP-MS)

SPSS 16.0 was used for cluster analysis (CA) while SIMCA-P 13.0 with

-test and Rank-Sum test was used to identify the differential inorganic elements. In addition

the characteristic spectrum of the inorganic elements for calcined Alumen and counterfeit calcined alumen were established.

Result:

Calcined Alumen had highest contents of K and Al while counterfeit calcined Alumen has highest contents of Al and Fe; Cr

and Mn contents in calcined Alumen were relatively higher

while Mn

and Ga contents in processed products of ammonium alum were relatively higher. The content of K in calcined Alumen was about 205 times of that of counterfeit products. On the contrary

the average contents of Fe

Mn and Ga in counterfeit products of ammonium alum were much higher than those in calcined Alumen

27 times

respectively. A total of 18 samples were clustered into two categories in CA: calcined Alumen and processed products of ammonium alum. 18 inorganic elements showed significant difference in contents(

0.05)

and Pb respectively. Characteristic spectrum of 21 inorganic elements in calcined Alumen and counterfeit calcined Alumen were established.

Conclusion:

This method can be used for quality control of calcined Alumen.

关键词

Keywords

references

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Related Author

Sheng-jin LIU

Ting-ting QIAO

Yu-lu MA

Fang FANG

Rui-chao LIN

Yun-fei SUN

Jiang YANG

De-kang WU

Related Institution

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, State Administration of Traditional Chinese Medicine(TCM) Key Laboratory of Chinese Medicine Resource Recycling Utilization, Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Nanjing University of Chinese Medicine

Jiangsu Province Hospital of TCM

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Affiliated Hospital of Chengdu University

Shandong Analysis and Test Center

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