Modern Pharmacological Toxicology and Clinical Application of Antitumor Nanometer Realgar

Ke PEI; Hui-chao FENG; Wen-li ZHENG; Hui-jie LI

doi:10.13422/j.cnki.syfjx.20190520

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Modern Pharmacological Toxicology and Clinical Application of Antitumor Nanometer Realgar

Review | 更新时间：2021-02-09

- Modern Pharmacological Toxicology and Clinical Application of Antitumor Nanometer Realgar
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 5, Pages: 214-219(2019)
- 作者机构：
  
  1.山东中医药大学，济南　 250355；
  2.山东中医药大学　附属医院，济南　 250011
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190520
  CLC： R22;R242;R2-031;R287;R285.5
- Received：01 August 2018，
  
  Published Online：19 November 2018，
  
  Published：05 March 2019
- 稿件说明：
移动端阅览
Ke PEI, Hui-chao FENG, Wen-li ZHENG, et al. Modern Pharmacological Toxicology and Clinical Application of Antitumor Nanometer Realgar[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(5): 214-219.
DOI：

Ke PEI, Hui-chao FENG, Wen-li ZHENG, et al. Modern Pharmacological Toxicology and Clinical Application of Antitumor Nanometer Realgar[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(5): 214-219. DOI： 10.13422/j.cnki.syfjx.20190520.

摘要

雄黄，辛温，有毒，归肝、大肠经，属于以毒攻毒的药物，具有解疟抗癌、解毒杀虫、燥湿祛痰的作用。古代医家常应用雄黄治疗痈肿疔疮，聚积腹痛等，近现代医家用以治疗恶性肿瘤及血液病，由古到今为临床所用。雄黄的毒性导致其用药安全范围小，现代学者将传统中药与纳米科技手段相结合，将雄黄研磨成为纳米雄黄，相比较雄黄可言，提高了生物利用度，降低了雄黄的体内毒性，将雄黄的临床应用推动到了新的高度。现代药理研究通过运用纳米雄黄干预肺癌细胞、卵巢癌细胞、皮肤癌细胞、宫颈癌细胞和白血病细胞等实验，证实纳米雄黄具有抑制细胞增殖，诱导细胞凋亡、诱导细胞分化、抑制核酸合成、抑制新生血管生成等功能，还具有抗病毒、杀菌镇痛的功效。现代毒理研究通过应用不同浓度的纳米雄黄制剂给予小鼠灌胃治疗，记录各时间段小鼠的症状体征及各项辅助检查指标，得出安全剂量下纳米雄黄对血液生化指标等影响均处于正常范围内。临床试验应用纳米雄黄外敷治疗恶性肿瘤破溃创面，发现纳米雄黄有促进患者肿瘤破溃创面愈合，减轻疼痛，缓解渗血、流脓、散发恶臭味等临床症状，提高患者生活质量的作用。并且用药简易，患者依从性好，无需住院治疗，节约医疗资源，值得临床推广应用。

Abstract

Realgar is toxic and belongs to drug of poison attack

with anti-cancer

anti-pest

dry wet and expectorant effects. Ancient doctors often used realgar to treat carbuncle

boil

abdominal pain and other diseases. Modern doctors use it to treat malignant tumors and blood diseases. The toxicity of realgar results in a small range of safety in its drug use. Modern scholars combine traditional Chinese medicine with nano-technology means to grind realgar into nano-realgar. Compared with realgar

nano-realgar has an improved bioavailability and reduced toxicity

in vivo

. Modern pharmacological researches use nano-realgar to interven lung cancer cells

skin cancer cells

cervical cancer cells

ovarian cancer cells and leukemia cells in experiments

which confirmed that nano-realgar has effects in inhibiting cell proliferation

inducing apoptosis and cell differentiation

inhibiting nucleic acid synthesis and angiogenesis

but with antiviral

sterilization of analgesic effects. Modern toxicological studies have been conducted in mice through intragastric treatment with different concentrations of nano-realgar preparation. The symptoms and signs of mice and various auxiliary examination indexes were recorded at different time periods. It was concluded that nano-realgar has regular effects on blood biochemical indexes at safe doses. In clinical trials

nano-realgar was applied to treat damaged wound surface of malignant tumor. It was found that nano-realgar can promote healing of wound surface of tumor

alleviate pain

relieve clinical symptoms

such as bleeding

purulence and odor

and improve quality of life of patients. In addition

with a simple usage and good patient compliance

administration with nano-realgar requires no hospitalization

can save medical resources

and is worthy of clinical promotion and application.

关键词

Keywords

references

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