Effect of Modified Bazhentang on Cerebrovascular Reserve and Hemorheology in Patients with Chronic Cerebral Circulation Insufficiency

Zhong-bo XU; Fei-xiang GONG; Wei-min LIAO; Xin FENG; Xin-xin YE

doi:10.13422/j.cnki.syfjx.20190525

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Effect of Modified Bazhentang on Cerebrovascular Reserve and Hemorheology in Patients with Chronic Cerebral Circulation Insufficiency

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- Effect of Modified Bazhentang on Cerebrovascular Reserve and Hemorheology in Patients with Chronic Cerebral Circulation Insufficiency
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 7, Pages: 43-48(2019)
- 作者机构：
  
  1.江西中医药大学　附属医院，南昌　 330006；
  2.江西省妇幼保健院，南昌　 330006；
  3.福建中医药大学　护理学院，福州　 350122
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190525
  CLC： R22;R242;R2-031;R287
- Received：16 August 2018，
  
  Published Online：19 November 2018，
  
  Published：05 April 2019
- 稿件说明：
移动端阅览
Zhong-bo XU, Fei-xiang GONG, Wei-min LIAO, et al. Effect of Modified Bazhentang on Cerebrovascular Reserve and Hemorheology in Patients with Chronic Cerebral Circulation Insufficiency[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(7): 43-48.
DOI：

Zhong-bo XU, Fei-xiang GONG, Wei-min LIAO, et al. Effect of Modified Bazhentang on Cerebrovascular Reserve and Hemorheology in Patients with Chronic Cerebral Circulation Insufficiency[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(7): 43-48. DOI： 10.13422/j.cnki.syfjx.20190525.

摘要

目的：

探讨加减八珍汤对慢性脑动脉供血不足患者脑血管储备功能及血流变学的影响。

方法：

对2018年1月至2018年6月在江西省中医院就诊的80例符合纳入条件患者，使用Stata 13.0产生随机序列，随机分为观察组和对照组，各40例。两组研究对象均接受降压、降糖、降脂等基础治疗，对照组同时给予尼膜地平片治疗，观察组在对照组基础上给予加减八珍汤治疗，总疗程为30 d。分别在治疗前后，通过经颅多普勒超声(TCD)检测两组脑血管储备功能，评估临床疗效，检测血流变学、血常规及肝肾功能。

结果：

观察组有效率为92.5%，对照组有效率为80%，观察组临床疗效优于对照组(

0.05)；与本组治疗前比较，观察组治疗后脑血管储备(CVR)，屏气指数(BMI)，平均血流速度(Vm)均明显升高(

0.05)；与本组治疗前比较，观察组治疗后血细胞比容、全血表观黏度高切、低切、血浆黏度均明显下降(

0.05)。两组治疗后进行比较，观察组CVR

BMI

Vm均高于对照组(

0.05)，观察组血细胞比容、全血表观黏度高切、低切、血浆黏度均明显低于对照组(

0.05)；两组患者安全性指标治疗后均在正常范围，与本组治疗前比较均无统计学差异。

结论：

加减八珍汤能够有效治疗慢性脑供血不足，通过提高脑血管储备功能，改善血液流动性，从而缓解临床症状，且不存在安全问题，为中医药治疗慢性脑供血不足提供了理论依据。

Abstract

Objective:

To observe the effect of modified Bazhentang on cerebrovascular reserve and hemorheology in patients with chronic cerebral circulation insufficiency.

Method:

Totally 80 patients treated at Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2018 to June 2018 in line with the inclusion criteria were randomly divided into the observation group (40 cases) and the control group (40 cases) using the random sequence of Stata 13.0. Both groups received basic treatments

such as antihypertensive

hypoglycemic and lipid-lowering. In addition to the therapy of the control group

the control group was also given nimodipine tablet treatment

and the observation group was given modified Bazhentang treatment

with a total course of 30 days. Before and after treatment

transcranial doppler ultrasonography (TCD) was used to detect the cerebrovascular reserve function of the two groups

so as to evaluate the clinical efficacy

and detect the hemorheology

blood routine

hepatic and renal function.

Result:

The effective rate of the observation group was 92.5%

and that of the control group was 80%. The clinical efficacy of the observation group was better than that of the control group (

0.05). Compared with before treatment

cerebrovascular reserve (CVR)

breath-holding index (BMI) and mean blood flow velocity (Vm) were significantly increased in the observation group after treatment (

0.05). Compared with before treatment

hematocrit

whole blood apparent viscosity high cut

low cut

plasma viscosity were all decreased in the observation group after treatment (

0.05). After treatment

CVR

BMI

and Vm of the observation group were higher than those of the control group (

0.05)

and hematocrit

whole blood apparent viscosity high cut

low cut

plasma viscosity of the observation group were lower than those of the control group (

0.05). Safety indexes of the two groups were in the normal range after treatment

with no statistical difference compared with before treatment.

Conclusion:

Modified Bazhentang can effectively treat chronic cerebral circulation insufficiency. By improving the function of cerebrovascular reserve and cerebral blood flow

it can alleviate clinical symptoms without safety problems

so as to provide a theoretical basis for the treatment of chronic cerebral circulation insufficiency with traditional Chinese medicine.

关键词

Keywords

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