Clinical Efficacy of Shensuyin in Treating Adult Viral Myocarditis with Syndrome of Insufficiency of Lung-Qi

Zhi-qiang LI; Xue-hui WANG; Hong-juan CHANG

doi:10.13422/j.cnki.syfjx.20190531

您当前的位置：

首页 >

文章列表页 >

Clinical Efficacy of Shensuyin in Treating Adult Viral Myocarditis with Syndrome of Insufficiency of Lung-Qi

Classic Prescriptions | 更新时间：2021-02-09

- Clinical Efficacy of Shensuyin in Treating Adult Viral Myocarditis with Syndrome of Insufficiency of Lung-Qi
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 5, Pages: 73-78(2019)
- 作者机构：
  
  1.新乡医学院　第一附属医院，河南　新乡　 453100；
  2.新乡医学院　护理学院，河南　新乡　 453108
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190531
  CLC： R25;R256;256.2;R54;R542.2
- Received：01 August 2018，
  
  Published Online：13 November 2018，
  
  Published：05 March 2019
- 稿件说明：
移动端阅览
Zhi-qiang LI, Xue-hui WANG, Hong-juan CHANG. Clinical Efficacy of Shensuyin in Treating Adult Viral Myocarditis with Syndrome of Insufficiency of Lung-Qi[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(5): 73-78.
DOI：

Zhi-qiang LI, Xue-hui WANG, Hong-juan CHANG. Clinical Efficacy of Shensuyin in Treating Adult Viral Myocarditis with Syndrome of Insufficiency of Lung-Qi[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(5): 73-78. DOI： 10.13422/j.cnki.syfjx.20190531.

摘要

目的：

探讨参苏饮加减治疗病毒性心肌炎(VMC)肺气不足证的临床疗效及对辅助性T细胞17(Th17)，调节性T细胞(Treg)及相关炎性指标水平的影响。

方法：

收治VMC慢性期患者104例作为研究对象，采用随机按数字表法分为对照组和观察组各52例，对照组参照《中国心力衰竭诊断和治疗指南2014》常规治疗。观察组在对照组治疗的基础上内服参苏饮加减，1剂/d，分早晚2次温服。两组均连续治疗8周。比较两组患者肺气不足证症状积分、血清肌钙蛋白I(cTnI)和心型游离脂肪酸结合蛋白(H-FABP)水平、心功能评价及临床疗效。流式细胞仪检测两组外周血Th17细胞和Treg细胞水平。检测两组血清白细胞介素(IL)-17，IL-21，IL-10水平。

结果：

观察组患者肺气不足证症状（气短、乏力、胸闷隐痛、自汗恶风、咳嗽）评分均明显低于对照组(

0.01)；观察组治疗后血清cTnI和H-FABP水平均明显低于对照组，左心室射血分数(LVEF)及舒张早期／舒张晚期最大血流速度(E/A)值水平均显著高于对照组(

0.01)；观察组临床疗效总有效率为92.16%，多于对照组的74%(

0.05)；观察组治疗后Th17细胞和Th17/Treg水平均明显低于对照组，Treg细胞高于对照组(

0.01)；观察组患者血清IL-17，IL-21，IL-10水平均明显低于对照组(

0.01)。

结论：

在病毒性心肌炎常规治疗基础上，加服参苏饮加减治疗病毒性心肌炎肺气不足证疗效显著，调节Th17细胞和Treg细胞及相关因子水平可能是其作用途径之一。

Abstract

Objective:

To investigate the efficacy of Shensuyin in treating viralmyocarditis (VMC) with syndrome of insufficiency of lung-qi and the effect on levels of Th17 and Treg cells and relevant factors.

Method:

One hundred-four VMC cases were regaded as object of study and randomly divided into control group and observation group

with 52 cases in each group. Control group was treated with routine therapy by reference to '

Chinese Guidelines for Diagnosis and Treatment of Heart Failure

2014’. In addition to the therapy of control group

observation group on the basis of treatment in the control group with Shensuyin

1 dose/d

bid

. One course of treatment was 8 weeks for both groups. Scores of Shensuyin

serum levels of Troponin I (cTnI) and cardiac free fatty acid binding protein (H-FABP)

heart function and total efficacy were compared for both groups. Flow cytometry was used to detect peripheral blood levels of Th17 and Treg cells for the two groups. Serum levels of interleukin (IL)-17

IL-21

IL-10 were detected in both groups.

Result:

After treatment

scores of syndrome of Yin and Yang deficiency (shortness of breath

fatigue

dull chest pain

bad breath

cough) of observation group were obviously lower than those of control group (

0.01). Serum levels of H-FABP and cTnI of observation group were remarkably lower

while LVEF and E/A were higher than those of control group after treatment (

0.01). Total efficacy of observation group was 92.16%

which was higher than 74% of control group (

0.05). After treatment

peripheral blood levels of Th17 cell and Th17/Treg were obviously lower

while Treg cell was higher thancontrol group (

0.01). Serum level of IL-17

IL-21 of observation group was remarkably lower

while IL-10 was higher than control group after treatment (

0.01).

Conclusion:

In addition to the routine therapy of VMC

the efficacy of Shensuyin has a significant effect in treating VMC with syndrome of lung qi deficiency

and the regulatory effect on levels of Th17 and Treg cells and relevant factors may be one of the effective ways.

关键词

Keywords

references

杨红灵．加味人参养荣汤对宫颈癌化疗患者免疫功能和生存质量的影响 [J]. 中医学报， 2017 , 32 ( 8 ): 1377 - 1380 .

李景业，马长生 . 病毒性心肌炎病原学检测研究进展 [J]. 临床心血管病杂志， 2016 , 32 ( 7 ): 658 - 662 .

刘芳，王雪峰．小儿病毒性心肌炎中医治疗述评 [J]. 中国中西医结合儿科学， 2015 , 7 ( 2 ): 109 - 111 .

赵述强，李翔宇 . 病毒性心肌炎中西医防治的研究进展 [J]. 中西医结合心脑血管病杂志， 2016 , 14 ( 18 ): 2115 - 2118 .

中华中医药学会．中医内科常见病诊疗指南（西医疾病部分）病毒性心肌炎 [J]. 中国中医药现代远程教育， 2011 , 9 ( 18 ): 148 - 150 .

张灵敏 . 参苏饮加减治疗病毒性心肌炎的实验研究 [D]．石家庄：河北医科大学， 2009 .

张发君，马萍，徐春肖，等 . 参苏饮对“肺气虚外感”大鼠肺组织IL-1β和IL-18影响实验研究 [J]. 亚太传统医药， 2018 , 14 ( 5 ) 20 - 23 .

赵保胜，李兰芳，马悦颖，等 . 参苏饮含药血清对小鼠巨噬细胞Toll样受体及其下游信号转导通路的影响 [J]. 中国中药杂志， 2007 , 32 ( 4 ): 327 - 332 .

林媛媛，吴乐程，孙成勇，等．病毒性心肌炎患者外周血中Th17细胞和调节性T细胞的变化研究 [J]. 中华医院感染学杂志， 2017 , 27 ( 22 ): 5129 - 5132 .

中华医学会心血管病学分会．中华心血管病杂志编辑委员会．中国心力衰竭诊断和治疗指南2014 [J]. 中华心血管病杂志， 2014 , 42 ( 2 ): 98 - 122 .

陈灏珠，林果为．实用内科学 [M]. 北京：人民卫生出版社， 2014 ： 1586 - 1588 .

赵添，赵地，王维，等．中药复方治疗病毒性心肌炎的用药规律 [J]. 山东中医杂志， 2016 , 35 ( 7 ): 612 - 614 .

康日艳．邵念方教授益气保丹饮治疗心肺气虚型胸痹经验 [J]. 中医学报， 2010 , 25 ( 6 ): 1089 - 1090 .

王崇权，张明雪．从温病论治病毒性心肌炎 [J]. 辽宁中医药大学学报， 2011 , 13 ( 4 ): 33 - 34 .

ZHOU F J , ZHOU C Y , TIAN Y J , et al . Diagnostic value of analysis of H-FABP, NT-proBNP, and cTnI in heart function in children with congenital heart disease and pneumonia [J]. Eur Rev Med Pharmacol Sci , 2014 , 18 ( 10 ): 1513 - 1516 .

刘宇红，高东美，张友良，等．心型游离脂肪酸结合蛋白定性检查在急性非ST段抬高型心肌梗死超早期鉴别诊断中的应用 [J]. 中华临床医师杂志：电子版， 2012 , 6 ( 5 ): 1298 - 1299 .

XIE J , NIE S , YU Q , et al . Lactobacillus plantarum NCU116 attenuates cyclophosphamide-Induced immunosuppression and regulates Th17/Treg cell immune responses in mice [J]. J Agric Food Chem , 2016 , 64 ( 6 ): 1291 - 1297 .

Jenabian M A , Patel M , Kema I , et al . Soluble CD40-ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HⅣ infection [J]. Clin Exp Immunol , 2014 , 178 ( 1 ): 102 - 111 .

Son H J , Lee S H , Lee S Y , et al . Oncostatin m suppresses activation of IL-17/Th17 via SOCS3 regulation in CD4 ＋ T cells [J]. J Immunol , 2017 , 198 ( 4 ): 1484 - 1491 .

ZHANG Q , FU L , LIANG Y , et al . Exosomes originating from MSCs stimulated with TGF-β and IFN-γ promote Treg differentiation [J]. J Cell Physiol , 2018 , 233 ( 9 ): 6832 - 6840 .

OUYANG H , XIANG L , CHEN J , et al . Significant reduction of peripheral blood interleukin-35 and CD4 ＋ EBI3 ＋ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients [J]. Cent Eur J Immunol , 2017 , 42 ( 1 ): 91 - 96 .

杨帆，王红，谭保平，等．白细胞介素21在小鼠病毒性心肌炎中的表达及其与抗ANT抗体的相关性 [J]. 中国免疫学杂志， 2015 , 31 ( 4 ): 453 - 455,461 .

CEN Z , GUO Y , KONG Q , et al . IL-10-producing B cells involved in the pathogenesis of coxsackie virus B3-induced acute viral myocarditis [J]. Int J Clin Exp Pathol , 2015 , 8 ( 1 ): 830 - 835 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Efficacy of Shibuwan Jiawei in Treating Premature Ovarian Failure with Syndrome of Yang Deficiency of Spleen and Kidney and Its Mechanism

International Clinical Practice Guideline of Traditional Chinese Medicine ‧ Viral Myocarditis

Anti-oxidation and Anti-inflammatory Effect of Yixinshu Capsule in Treatment of Qi-Yin Deficiency in Viral Myocarditis

Clinical Efficacy of Taohua Tang and Buzhong Yiqi Tang in Treatment of Deficiency Syndrome of Crohn's Disease

Optimization of Anti-coxsackie B Complex Capsule for Treating Myocarditis Induced by Coxsackie B Virus and Anti-stress Effect of Capsule

Related Author

XIONG Xiao-li

WANG Qiao-ying

ZENG Xiao-xia

LI Zhao-ai

Ren-dong LI

Chen WANG

Related Institution

Sichuan Academy of Medical Sciences, Sichuan People's Hospital

Chengdu Fifth People's Hospital Chengdu

Affiliated Hospital of North Sichuan Medical College

North Sichuan Medical College

Traditional Chinese Medicine Hospital of Henan Province

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰