Discovery and Application of Quality Marker of Traditional Chinese Medicine Based on Integrative Pharmacology

Hai-yu XU; Wen-bin HOU; Ke LI; Ye SHEN; Shi-huan TANG; Fei-fei GUO; Jing-jing ZHANG; Hong-wei WU; Ping WANG; Jin SU; Rong-rong ZHOU; Ya-zhuo LI; Lan WANG; Lei WANG; Lei-lei GONG; Hong-jun YANG; Chang-xiao LIU

doi:10.13422/j.cnki.syfjx.20190546

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Discovery and Application of Quality Marker of Traditional Chinese Medicine Based on Integrative Pharmacology

Monograph | 更新时间：2021-02-09

- Discovery and Application of Quality Marker of Traditional Chinese Medicine Based on Integrative Pharmacology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 6, Pages: 1-8(2019)
- 作者机构：
  
  1.中国中医科学院　中药研究所，北京　 100700；
  2.天津药物研究院　新药评价研究中心，释药技术与药物代谢动力学国家重点实验室，天津　 300193；
  3.齐鲁工业大学（山东省科学院）自动化研究所，山东省科学院　超宽带与太赫兹技术培育性重点实验室，济南　 250014；
  4.中国中医科学院　中药资源中心，北京　 100700；
  5.山西中医药大学　基础医学院，山西　晋中　 030600
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190546
  CLC： R22;R24;R28;R9
- Received：08 October 2018，
  
  Published Online：2018-13-11，
  
  Published：20 March 2019
- 稿件说明：
移动端阅览
Hai-yu XU, Wen-bin HOU, Ke LI, et al. Discovery and Application of Quality Marker of Traditional Chinese Medicine Based on Integrative Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(6): 1-8.
DOI：

Hai-yu XU, Wen-bin HOU, Ke LI, et al. Discovery and Application of Quality Marker of Traditional Chinese Medicine Based on Integrative Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(6): 1-8. DOI： 10.13422/j.cnki.syfjx.20190546.

摘要

中药质量标志物是中药质量控制的新概念、新模式，将引领中药质量发展新方向。其中，如何表征中药整体质量属性及其生物学效应，是质量标志物研究的关键科学问题。针对此关键科学问题，本文提出基于整合药理学的中药质量标志物发现与确证的研究思路，即通过“化学指纹-代谢指纹-网络靶标-生物效应-中医功效”多维关联系统筛选候选中药质量标志物，在此基础上，基于“肠吸收-活性评价-数据挖掘”体系建立中药质量标志物与生物活性之间精确定量模型并明确其贡献度。以元胡止痛片和心速宁胶囊为案例，介绍基于整合药理学的中药质量标志物的研究进展。

Abstract

Quality marker(Q-marker) is a new concept and pattern for quality control of traditional Chinese medicine(TCM)

which will lead the development direction for quality control of TCM. Among them

how to characterize the overall quality attribute of TCM and its biological effect

is a critical scientific problem in the study of Q-marker. In this paper

integrated pharmacology is utilized to screen out and confirm the Q-marker from the complex system of TCM

so as to solve the critical scientific problem. System biology

in vivo

is firstly applied to establish the correlation of chemical fingerprints of TCM

their metabolic fingerprints

network targets

biological effects and efficacy of TCM

which is used to preliminary screen out Q-marker of TCM. Following that

a pharmacological method

in vitro

including intestinal absorption

in vitro

coupled with bioactivity assessment

is employed to simultaneously determine the absorbed doses of TCM and evaluate their biological activity. Furthermore

data mining is utilized to establish the exact quantitative mathematic model between Q-marker of TCM and bioactivity. Meanwhile

two representative examples

including Yuanhu Zhitong tablets

Xinsuning capsules

are introduced to identify Q-marker of TCM and establish their quality standards related with bioactivity

which will be beneficial to improve the level of quality control of TCM and ensure the effectiveness and safety of clinical applications.

关键词

Keywords

references

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