Pharmacological Mechanism of Xiaoyaosan in Treating Depression Due to Liver Stagnation and Spleen Deficiency

Dan WU; Yao GAO; Jie XING; Jun-sheng TIAN; Xue-mei QIN

doi:10.13422/j.cnki.syfjx.20190606

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Pharmacological Mechanism of Xiaoyaosan in Treating Depression Due to Liver Stagnation and Spleen Deficiency

Review | 更新时间：2021-02-09

- Pharmacological Mechanism of Xiaoyaosan in Treating Depression Due to Liver Stagnation and Spleen Deficiency
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 8, Pages: 187-193(2019)
- 作者机构：
  
  山西大学　中医药现代研究中心，地产中药功效物质研究与利用山西省重点实验室，太原　 030006
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190606
  CLC： R2-0;R22;R285.5;R284.1;R289
- Received：29 August 2018，
  
  Published Online：05 December 2018，
  
  Published：20 April 2019
- 稿件说明：
移动端阅览
Dan WU, Yao GAO, Jie XING, et al. Pharmacological Mechanism of Xiaoyaosan in Treating Depression Due to Liver Stagnation and Spleen Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 187-193.
DOI：

Dan WU, Yao GAO, Jie XING, et al. Pharmacological Mechanism of Xiaoyaosan in Treating Depression Due to Liver Stagnation and Spleen Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 187-193. DOI： 10.13422/j.cnki.syfjx.20190606.

摘要

抑郁症属中医“郁证”范畴，临床有诸多分型，肝郁脾虚证为主要的分型之一。逍遥散作为疏肝健脾经典方剂，其治疗肝郁脾虚型抑郁症具有确切疗效，且不良反应少、安全性高、患者依从性好，与西药联合使用能降低西药的复发率和不良反应，是近年来研究的重点和热点。尽管已有许多专家和学者围绕逍遥散治疗肝郁脾虚型抑郁症的药理作用机制进行了大量的研究，但是，其作用机制仍不完全明确。此外，肝郁脾虚型抑郁症动物模型种类较多，鲜有逍遥散治疗肝郁脾虚型抑郁症较为系统的报道。因此，本文借助慢性温和不可预知应激抑郁模型(CUMS)和慢性束缚应激抑郁模型(CIS)两个经典的模型，从调节神经递质浓度、影响神经营养因子功能表达、调控下丘脑-垂体-肾上腺(HPA)轴功能失衡、改善肠道微生态与胃肠道功能、以及调控内源性代谢物水平、调节免疫炎症因子水平、改善突触结构及其可塑性等方面对逍遥散治疗肝郁脾虚型抑郁症的药理作用机制进行综述，为逍遥散治疗肝郁脾虚型抑郁症基础研究以及临床的应用提供参考依据。

Abstract

Depression belongs to the category of " stagnation syndrome" in traditional Chinese medicine. There are many clinical types of depression in which liver stagnation and spleen deficiency syndrome is one of the main types. As a classic prescription for liver-soothing and spleen-strengthening

Xiaoyaosan has a definite curative effect in the treatment of depression due to liver stagnation and spleen deficiency. With fewer adverse reactions

a high safety and good patient compliance

it can be combined with western medicine to reduce the recurrence rate and adverse reactions of western medicine

and has become the focus and hotspot of research in recent years. Although many experts and scholars have conducted a lot of research on the pharmacological mechanism of Xiaoyaosan in the treatment of depression due to liver stagnation and spleen deficiency

its mechanism is still unclear. In addition

there are many types of animal models for depression due to liver stagnation and spleen deficiency but only a few systematic reports on Xiaoyaosan in treating depression of liver stagnation and spleen deficiency. Therefore

based on two classic models of chronic mild unpredictable stress depression model (CUMS) and chronic restraint stress depression model (CIS)

a review was conducted on the pharmacological mechanisms of Xiaoyaosan in the treatment of depression due to liver stagnation and spleen deficiency by regulating neurotransmitter concentration

affecting the expression of neurotrophic factor

regulating hytothalamus-pitutary-adrenal(HPA)axis imbalance

improving intestinal micro-ecology and gastrointestinal function

regulating endogenous metabolite levels and immune inflammatory factor levels and improving synaptic structure and plasticity

so as to provide potential guidelines for basis study and clinical application of Xiaoyaosan in the treatment of depression due to liver stagnation and spleen deficiency.

关键词

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references

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