Traditional Chinese Medicine Cognition and Modern Pharmaceutical Research on Effect of Cassia Twig and Cinnamomum Cassia in Treating Paralysis

Tian-wei XIA; Guo-wei ZHOU; Chen YAO; Chao ZHANG; Qing JIANG; Ji-rong SHEN

doi:10.13422/j.cnki.syfjx.20190607

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Traditional Chinese Medicine Cognition and Modern Pharmaceutical Research on Effect of Cassia Twig and Cinnamomum Cassia in Treating Paralysis

Review | 更新时间：2021-02-09

- Traditional Chinese Medicine Cognition and Modern Pharmaceutical Research on Effect of Cassia Twig and Cinnamomum Cassia in Treating Paralysis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 6, Pages: 218-226(2019)
- 作者机构：
  
  1.南京中医药大学　第一临床医学院，南京　 210023；
  2.南京中医药大学　附属医院，南京　 210029；
  3.南京大学　医学院　附属鼓楼医院，南京　 210008
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190607
  CLC： R2-0;R22;R285.5;R284.1
- Received：07 September 2018，
  
  Published Online：12 May 2018，
  
  Published：20 March 2019
- 稿件说明：
移动端阅览
Tian-wei XIA, Guo-wei ZHOU, Chen YAO, et al. Traditional Chinese Medicine Cognition and Modern Pharmaceutical Research on Effect of Cassia Twig and Cinnamomum Cassia in Treating Paralysis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(6): 218-226.
DOI：

Tian-wei XIA, Guo-wei ZHOU, Chen YAO, et al. Traditional Chinese Medicine Cognition and Modern Pharmaceutical Research on Effect of Cassia Twig and Cinnamomum Cassia in Treating Paralysis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(6): 218-226. DOI： 10.13422/j.cnki.syfjx.20190607.

摘要

桂枝、肉桂是治疗痹证的常用中药，相关的古籍记载众多、繁杂。桂枝气薄，走而不守，温通之力强，可祛风散寒化瘀，常配伍辛温、辛热之品，治疗实痹、初痹；肉桂气厚，守而不走，温补之力强，善温补肾阳，多配伍温补之品，治疗虚痹、久痹。现代药学研究发现二药活性成分大体相同，肉桂的活性成分多于桂枝。其治疗痹证的机制主要体现在：通过抑制核转录因子-

B(NF-

B)，丝裂原活化蛋白激酶(MAPK)，两面神激酶／信号转导子和转录激活子(JAK/STAT)等信号通路发挥抗炎或免疫调节作用；通过抑制成纤维细胞、破骨细胞、骨髓间充质干细胞等细胞的增殖，促进成骨细胞的增殖，发挥调节细胞增殖的作用；通过清除氧自由基发挥抗氧化作用；通过调节瞬时感受器电位通道A1和V1亚型(TRPA1，TRPV1)发挥调节疼痛的作用；通过调节肠道激素-1(GLP-1)分泌、改善胰岛素抵抗等发挥增加糖脂代谢、减重的作用。主要活性成分肉桂醛体内代谢不稳定，易被氧化成肉桂酸。二药及其所含成分的毒性相对较小。现梳理二药的古籍记载、中医对二药治痹功效的认识，综述近年来相关药化、药理、药代、毒理的研究成果，并分析相关的问题，旨在为进一步研究与应用提供依据。

Abstract

Cinnamomi Ramulus and Cinnamomi Cortex are widely used to treat paralysis in traditional Chinese medicine (TCM). There are numerous and complicated relative records in ancient literatures. Doctors often use Cinnamomi Ramulus to dispel wind and cold

remove blood stasis and combine with warm-natured and heat-natured herbs to treat excess paralysis and early-stage paralysis. And Cinnamorni Cortex is used to warm and invigorate kidney Yang and combine with warm-benefiting herbs to treat deficiency paralysis and chronicle paralysis. However

modern pharmaceutical studies reported that their active substances are almost the same. The active substances in Cinnamomi Cortex are more than those in Cinnamomi Ramulus. The mechanisms of treating paralysis include: suppressing inflammation and regulating immunity by down-regulating nuclear factors(NF)-

mitogen activated protein kinase(MAPK)

Janus kinase-signal transducers/activators of transcription(JAK/STAT) signaling pathways

regulating cell proliferation by inhibiting the proliferation of fibroblasts

osteoclasts and bone marrow mesenchymal stem cells and promoting the proliferation of osteoblast

resisting oxidation by scavenging oxygen free radicals

regulating pain by mediating TRPA1 and TRPV1

and enhancing substance metabolism and losing weight by regulating the secretion of intestinal hormones (Ghrelin

GLP-1) and improving insulin resistance. The main active ingredient Cinnamaldehyde is unstable

in vivo

and easily oxidized to cinnamic acid. The toxicity of the two medicines and their components are relatively low. This paper reviews and analyses relative records in ancient literatures

traditional Chinese medicine cognition of their effects in treating paralysis

the achievements and problems of chemical

pharmacological

pharmacokinetic and toxicological researches in recent years

with the aim to provide theoretical basis for further research and application.

关键词

Keywords

references

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Mechanism of Cinnamaldehyde in Promoting Wound Healing in Diabetes Rats via PINK1/Parkin-mediated Mitochondrial Autophagy

Cinnamomi Cortex Regulates Incretin Effect in Diabetic Rats

Related Author

Yu-jing XIE

Jia-nan ZHANG

Dong-ning ZHU

Ke-ning ZHENG

Chao CHEN

Shu-mei WANG

CAO Yuqing

GUO Yang

Related Institution

School of Traditional Chinese Medicine(TCM), Guangdong Pharmaceutical University, Guangdong Province Research Center for TCM Quality Engineering Technology, Key Laboratory of TCM Digitalization Quality Evaluation Under State Administration of TCM

Institute of Basic Theory for Chinese Medicine，China Academy of Chinese Medical Sciences

Institute of Information on Traditional Chinese Medicine，China Academy of Chinese Medical Sciences

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Institute of Basic Research in Clinical Medicine，China Academy of Chinese Medical Sciences

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