Effect of Modified Qingre Shenshi Tang on Inflammatory Factors, Oxidative Stress and Immune Function in Chronic Antral Sinusitis Patients with Damp-heat Pouring Downward Syndrome

Ning ZHANG; Xiao-li ZHOU; Shuai LIU

doi:10.13422/j.cnki.syfjx.20190623

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Effect of Modified Qingre Shenshi Tang on Inflammatory Factors, Oxidative Stress and Immune Function in Chronic Antral Sinusitis Patients with Damp-heat Pouring Downward Syndrome

Clinic | 更新时间：2021-02-09

- Effect of Modified Qingre Shenshi Tang on Inflammatory Factors, Oxidative Stress and Immune Function in Chronic Antral Sinusitis Patients with Damp-heat Pouring Downward Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 13, Pages: 93-98(2019)
- 作者机构：
  
  1.河南省中医院，郑州　 450002；
  2.河南中医药大学　第三附属医院，郑州　 450008；
  3.郑州颐和医院，郑州　 450046
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190623
  CLC： R22; R242; R2-031; R287
- Received：20 August 2018，
  
  Published Online：05 December 2018，
  
  Published：05 July 2019
- 稿件说明：
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Ning ZHANG, Xiao-li ZHOU, Shuai LIU. Effect of Modified Qingre Shenshi Tang on Inflammatory Factors, Oxidative Stress and Immune Function in Chronic Antral Sinusitis Patients with Damp-heat Pouring Downward Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(13): 93-98.
DOI：

Ning ZHANG, Xiao-li ZHOU, Shuai LIU. Effect of Modified Qingre Shenshi Tang on Inflammatory Factors, Oxidative Stress and Immune Function in Chronic Antral Sinusitis Patients with Damp-heat Pouring Downward Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(13): 93-98. DOI： 10.13422/j.cnki.syfjx.20190623.

摘要

目的：

观察清热渗湿汤加减对湿热下注型慢性肛窦炎患者炎症因子、氧化应激及免疫功能的影响，探讨其机制。

方法：

随机将2017年6月至2018年4月河南省中医院收治的94例湿热下注型慢性肛窦炎患者分为观察组和对照组，各47例，对照组采用甲硝唑联合庆大霉素灌肠治疗，在对照组的基础上，观察组给予清热渗湿汤加减方水煎服。于治疗前后，观察两组的症状评分，白细胞介素-2(IL-2)，IL-6，IL-8，肿瘤坏死因子-

(TNF-

)，

-干扰素(IFN-

)，超氧化歧化酶(SOD)，丙二醛(MDA)，晚期氧化蛋白产物(AOPP)，8-羟基脱氧鸟苷(8-OHDG)，CD3

＋

，CD4

＋

，CD8

＋

水平，并观察两组的疗效、不良反应及复发情况。

结果：

治疗后，观察组总有效率(87.23%)高于对照组(78.72%)(

＝2.067，

0.05)；观察组治疗后的肛门疼痛、坠胀、潮湿等症状评分低于对照组(

0.05)；观察组治疗后的TNF-

，IL-6，IL-8，MDA，AOPP，8-OHDG

CD8

＋

水平低于对照组(

0.05)，IL-2，IFN-

，SOD，CD3

＋

，CD4

＋

，CD4

＋

/CD8

＋

水平高于对照组(

0.05)；随访3个月后，观察组复发率4.26%低于对照组21.28%(10/47)(

＝4.681，

0.05)。

结论：

清热渗湿汤加减方治疗湿热下注型慢性肛窦炎的疗效较好，缓解症状，抑制炎症反应，调节氧化应激，改善免疫功能，控制复发率，有利于患者康复。

Abstract

Objective:

To explore effect of modified Qingre Shenshi Tang on inflammatory factors

oxidative stress and immune function in chronic antral sinusitis patients with damp-heat pouring downward syndrome.

Method:

A total of 94 cases of chronic antral sinusitis treated in our hospital from June 2017 to April 2018 were randomly divided into two groups

with 47 cases in each group. Control group was treated with metronidazole combined with gentamicin enema. In addition to the therapy of control group

the treatment group was given modified Qingre Shenshi Tang. The symptom scores

interleukin-2 (IL-2)

IL-6

IL-8

tumor necrosis factor-

(TNF-

)

gamma interferon (IFN-

)

super oxide dismutase (SOD)

malondialdehyde (MDA)

advanced oxidation protein products (AOPP)

8-hydroxy deoxyguanosine (8-OHDG)

CD3

CD4

CD8

levels of the two groups were observed before and after treatment

and the curative effect

reactions and relapse were observed.

Result:

After treatment

the total effective rates of treatment group(87.23%) and control group (78.72%) showed statistically significant differences (

=2.067

0.05). The symptoms of anal pain

swelling and dampness in the treatment group were lower than those in control group (

0.05). The levels of TNF-

IL-6

IL-8

MDA

AOPP

8-OHDG

CD8

in the treatment group were lower than those in control group (

0.05)

while the levels of IL-2

IFN-

SOD

CD3

CD4

/CD8

were higher than those in control group (

0.05). After 3 months of follow-up

the recurrence rates of treatment group [4.26%(2/47)] and control group [21.28%(10/47)]

were statistically significant (

=4.681

0.05).

Conclusion:

Modified Qingre Shenshi Tang has a good curative effect in the treatment of chronic antral sinusitis patients with damp-heat pouring downward syndrome by relieving symptoms

inhibiting inflammatory response

regulating oxidative stress

improving immune function and controlling recurrence rate.

关键词

Keywords

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