Effect of Modified Dingchuantang on Airway Function, Induced Phlegm Indexes and Inflammatory Factors in Children with Cough Variant Asthma of Wind Heat Attacking Lung Syndrome

Zhi-yong ZHENG; You-jia XU

doi:10.13422/j.cnki.syfjx.20190624

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Effect of Modified Dingchuantang on Airway Function, Induced Phlegm Indexes and Inflammatory Factors in Children with Cough Variant Asthma of Wind Heat Attacking Lung Syndrome

Clinic | 更新时间：2021-02-09

- Effect of Modified Dingchuantang on Airway Function, Induced Phlegm Indexes and Inflammatory Factors in Children with Cough Variant Asthma of Wind Heat Attacking Lung Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 13, Pages: 87-92(2019)
- 作者机构：
  
  1.广州市花都区妇幼保健院，广州　 510800；
  2.广东省中医院，广州　 510120
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190624
  CLC： R22; R242; R2-031; R287
- Received：07 September 2018，
  
  Published Online：05 December 2018，
  
  Published：05 July 2019
- 稿件说明：
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Zhi-yong ZHENG, You-jia XU. Effect of Modified Dingchuantang on Airway Function, Induced Phlegm Indexes and Inflammatory Factors in Children with Cough Variant Asthma of Wind Heat Attacking Lung Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(13): 87-92.
DOI：

Zhi-yong ZHENG, You-jia XU. Effect of Modified Dingchuantang on Airway Function, Induced Phlegm Indexes and Inflammatory Factors in Children with Cough Variant Asthma of Wind Heat Attacking Lung Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(13): 87-92. DOI： 10.13422/j.cnki.syfjx.20190624.

摘要

目的：

探讨小儿咳嗽变异性哮喘(CVA)应用定喘汤加减治疗的临床效果。

方法：

选取2016年6月至2018年6月广州市花都区妇幼保健院收治的142例CVA患儿，采取随机数字表法将这142例患者随机分成观察组与对照组，各71例。对照组采取吸入布地奈德粉吸入剂＋口服孟鲁司特钠咀嚼片治疗，观察组在此基础上内服定喘汤加减治疗。所有患儿均治疗8周。比较两组临床效果，治疗前后气道功能参数[第1秒用力呼气量占预计值百分比(FEV

%)及用力呼气50%，75%肺活量时的呼气流速(FEF

，FEF

)]，诱导痰指标[神经生长因子(NGF)，嗜酸性粒细胞(EOS)百分比，P物质(SP)]

，炎症因子[超敏C反应蛋白(hs-CRP)，白细胞介素(IL)-17，IL-23]水平变化，不良反应发生情况。

结果：

观察组总有效率为93.0%(66/71)，明显高于对照组的81.7%(58/71)(

0.05)。观察组患儿起效时间和症状消失时间均明显小于对照组(

0.05)。与本组治疗前比较，两组治疗后FEV

%，FEF

，FEF

均明显增加(

0.05)；且观察组升高更明显(

0.05)。两组治疗后诱导痰液中NGF，SP水平及EOS百分比和血清hs-CRP，IL-17，IL-23水平较本组治疗前均明显减少(

0.05)，且观察组降低更明显(

0.05)。观察组不良反应率7.0%(5/71)与对照组4.2%(3/71)比较差异无统计学意义。

结论：

小儿CVA应用定喘汤加减治疗可有效缓解患儿咳嗽等症状，减轻气道炎症，下调血中炎症因子表达，改善气道功能，疗效确切，安全可靠。

Abstract

Objective:

To explore the clinical effect of the application of modified Dingchuantang in the treatment of children with cough variant asthma (CVA).

Method:

Totally 142 children with CVA admitted by our hospital from June 2016 to June 2018 were selected and randomly divided into observation group (71 cases) and control group (71 cases) according to the random number table method. Patients in control group were treated with inhaled budesonide powder inhalation+ oral montelukast sodium chewable tablets

while patients in observation group were treated with modified Dingchuantang. All children were treated for 8 weeks. The two groups' clinical effects

changes of levels of airway function parameters [percentage of forced expiratory volume in the first second (FEV

%) and expiratory flow rate of forced expiratory in 50%and 75%vital capacity (FEF

FEF

)]

sputum induction indexes [nerve growth factor (NGF)

percentage of eosinophile (EOS)

substance P (SP)

inflammatory factors [hypersensitivity C reactive protein (hs-CRP)

interleukin (IL)-17 and IL-23]

and the occurrence of adverse reactions were compared.

Result:

The total effective rate of observation group was 93.0%(66/71)

which was significantly higher than that of control group [81.7%(58/71)

0.05] . Compared with control group

the onset time and symptom disappearance time of observation group were significantly lower than those of control group

with statistically significant differences (

0.05). Compared with before treatment

the values of FEV

FEF

and FEF

of two groups were increased significantly after treatment (

0.05)

particularly in observation group (

0.05). After treatment

the levels of NGF

SP and the percentage of EOS in induced sputum and the concentrations of hs-CRP

IL-17 and IL-23 in serum were significantly decreased in both groups (

0.05)

particularly in observation group (

0.05). The adverse reaction rate of observation group [7.0%(5/71)]

was higher than that of control group [4.2%(3/71)]

with no statistically significant difference.

Conclusion:

Modified Dingchuantang can effectively relieve cough and other symptoms in children with CVA

reduce airway inflammation

down-regulate the expressions of inflammatory factors in blood and improve airway function

with a definite curative effect

safety and reliability.

关键词

Keywords

references

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