Clinical Effect of Shugan Granule on Depression of Liver Qi Stagnation Type in Perimenopausal Period

Gui-xian WANG; Mai-hui CHANG; Qing-li LI; Yong-xin CHEN

doi:10.13422/j.cnki.syfjx.20190631

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Clinical Effect of Shugan Granule on Depression of Liver Qi Stagnation Type in Perimenopausal Period

Clinic | 更新时间：2021-02-09

- Clinical Effect of Shugan Granule on Depression of Liver Qi Stagnation Type in Perimenopausal Period
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 6, Pages: 114-119(2019)
- 作者机构：
  
  新乡医学院　第二附属医院，河南　新乡　 453002
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190631
  CLC： R289;R271;R271.1;R71;R711
- Received：01 August 2018，
  
  Published Online：2018-19-11，
  
  Published：20 March 2019
- 稿件说明：
移动端阅览
Gui-xian WANG, Mai-hui CHANG, Qing-li LI, et al. Clinical Effect of Shugan Granule on Depression of Liver Qi Stagnation Type in Perimenopausal Period[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(6): 114-119.
DOI：

Gui-xian WANG, Mai-hui CHANG, Qing-li LI, et al. Clinical Effect of Shugan Granule on Depression of Liver Qi Stagnation Type in Perimenopausal Period[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(6): 114-119. DOI： 10.13422/j.cnki.syfjx.20190631.

摘要

目的：

观察舒肝颗粒治疗围绝经期抑郁（肝郁气滞证）的临床疗效及对性激素和炎症因子的影响。

方法：

将120例患者随机按数字表法分为对照组和观察组各60例。两组患者均口服替勃龙片，2.5 mg／次，1次/d；对照组口服氟哌噻吨美利曲辛片，1片／次，早晨及中午各1次。观察组在对照组治疗的基础上口服舒肝颗粒，1袋／次，2次/d。两组疗程均为连续治疗8周。主要疗效指标采用汉密尔顿抑郁量

表1

7项(HAMD-17)，抑郁自评量表(SDS)和艾森克人格问卷(EPQ)；次要疗效指标采用焦虑自评量表(SAS)，肝郁气滞证评分、改良Kupperman(KI)评分，并检测促卵泡刺激素(FSH)，促黄体生成素(LH)，雌二醇(E

)，5-羟色胺(5-HT)，脑源性神经营养因子(BDNF)，白细胞介素-1

(IL-1

)，IL-6和肿瘤坏死因子-

(TNF-

)水平。于治疗前后各评价1次。

结果：

治疗后观察组临床抑郁疗效优于对照组(

＝2.038，

0.05)；观察组患者围绝经期综合征疗效优于对照组(

＝2.316，

0.05)；观察组患者HAMD-17，SDS和EPQ-N评分均低于对照组(

0.01)，EPQ-E评分高于对照组(

0.01)；观察组患者的SAS，KI和肝郁气滞证评分均低于对照组(

0.01)；观察组患者FSH和LH水平均低于对照组，E

和BDNF水平均高于对照组(

0.01)；观察组患者血清5-HT水平高于对照组，IL-1

，IL-6和TNF-

水平均低于对照组(

0.01)。

结论：

舒肝颗粒可减轻围绝经期抑郁肝郁气滞证患者的、焦虑及围绝经期症状，并具有调节性激素、减轻炎症反应和调节5-HT和BDNF作用，临床疗效优于单纯的西医治疗。

Abstract

Objective:

To observe the clinical efficacy of Shugan granule on perimenopausal depressive disorder (stagnation of liver Qi and Qi stagnation) and its effect on sex hormone and inflammatory factors.

Method:

One hundred and twenty patients were randomly divided into control group (60 cases) and observation group (60 cases) by random number table. Both groups got Tibolone tablets

2.5 mg/time

1 time/day. Patients in control group got flupentixol and melitracen tablets once every morning and noon

1 tablet/time. In addition to the therapy of control group

patients in observation group got Shugan granule

1 pack/time

2 times/days. And a course of treatment was 8 weeks. Main indexes were graded by Hamilton depression scale (HAMD-17)

self-rating depression scale (SDS) and Eysenck Personality Questionnaire (EPQ). And secondary indexes were scored by self-rating anxiety scale (SAS)

stagnation of liver Qi and Qi stagnation

improved kupperman (KI)

levels of follicle stimulating hormone (FSH)

luteinizing hormone (LH)

estradiol (E

)

5-serotonin (5-HT)

brain derived neurotrophic factor (BDNF)

interleukin-1

(IL-1

)

IL-6 and tumor necrosis factor-

(TNF-

) before and after treatment.

Result:

By rank sum test

the clinical efficacy on depressed and perimenopausal syndrome in observation groups was better than that in control group (

=2.038

0.05

=2.316

0.05). Scores of HAMD-17

SDS

EPQ-N

SAS

KI and stagnation of liver qi and qi stagnation were lower than those in control group (

0.01)

whereas score of EPQ-E was higher than that in control group (

0.01). And levels of FSH

IL-1

IL-6 and TNF-

were lower than those in control groups (

0.01). Levels of E

BDNF and 5-HT were higher than those in control groups (

0.01).

Conclusion:

Shugan granule can relieve depression

inquietude and symptoms caused by perimenopausal syndrome

regulate sex hormone

5-HT

BDNF and inflammatory reaction

with a better clinical effect than pure western medicine treatment.

关键词

Keywords

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