Clinical Efficacy of Xiaoxuan Zhiyun Tablet in Treating Cervical Vertigo with Syndrome of Phlegm and Blood Stasis Resistance

Cheng-lin DONG; Jing DING; Jing WANG; Yu-feng DING

doi:10.13422/j.cnki.syfjx.20190632

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Clinical Efficacy of Xiaoxuan Zhiyun Tablet in Treating Cervical Vertigo with Syndrome of Phlegm and Blood Stasis Resistance

Clinic | 更新时间：2021-02-09

- Clinical Efficacy of Xiaoxuan Zhiyun Tablet in Treating Cervical Vertigo with Syndrome of Phlegm and Blood Stasis Resistance
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 6, Pages: 108-113(2019)
- 作者机构：
  
  华中科技大学　同济医学院　附属同济医院，武汉　 430030
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190632
  CLC： R25;R255;R255.3;R441;R441.2
- Received：06 August 2018，
  
  Published Online：2018-19-11，
  
  Published：20 March 2019
- 稿件说明：
移动端阅览
Cheng-lin DONG, Jing DING, Jing WANG, et al. Clinical Efficacy of Xiaoxuan Zhiyun Tablet in Treating Cervical Vertigo with Syndrome of Phlegm and Blood Stasis Resistance[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(6): 108-113.
DOI：

Cheng-lin DONG, Jing DING, Jing WANG, et al. Clinical Efficacy of Xiaoxuan Zhiyun Tablet in Treating Cervical Vertigo with Syndrome of Phlegm and Blood Stasis Resistance[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(6): 108-113. DOI： 10.13422/j.cnki.syfjx.20190632.

摘要

目的：

探讨消眩止晕片治疗颈性眩晕痰瘀内阻证的疗效及对氧化应激和血清内皮素(ET)-1，5-羟色胺(5-HT)和一氧化氮(NO)水平的影响。

方法：

筛选符合要求就诊的颈性眩晕患者118例为研究对象，参照数字表法随机分为对照组和治疗组各59例。对照组采用正骨联合针刺治疗。治疗组在对照组治疗的基础上口服消眩止晕片，5片／次，3次/d。两组患者均进行3周的连续治疗。比较两组患者颈性眩晕症状与功能评估量表(ESCV)评分、眩晕障碍量表(DHI)评分、椎-基底动脉血流速度、生活质量及临床疗效。检测两组患者血清超氧化物歧化酶(SOD)，丙二醛(MDA)，ET-1，5-HT和NO水平。

结果：

治疗后，治疗组ESCV评分显著高于对照组，DHI评分明显低于对照组(

0.01)。治疗组治疗后患者左椎动脉、右椎动脉及基底动脉血流速度均显著高于对照组(

0.01)。治疗组患者的临床总有效率为98.25%，高于对照组的83.93%(

0.05)。治疗后，治疗组患者SF-36量表各项评分均显著高于对照组(

0.01)。治疗后，治疗组患者血清SOD，NO水平均显著高于对照组，MDA，ET-1和5-HT水平均明显低于对照组(

0.01)。

结论：

在正骨联合针刺治疗的基础上，加服消眩止晕片治疗颈性眩晕疗效显著，调节患者体内氧化应激及血清ET-1，5-HT和NO水平可能与其临床疗效有关。

Abstract

Objective:

To observe the efficacy of Xiaoxuan Zhiyun tablet in treating cervical vertigo with syndrome of phlegm and blood stasis resistance and its effect on oxidative stress and serum levels of endothelin-1(ET-1)

5-hydroxytryptamine (5-HT)

and nitric oxide (NO).

Method:

One hundred eighteen cervical vertigo cases were selected and randomly divided into control group (59 cases) and treatment group (59 cases) by random number table. Control group was given bone setting combined with acupuncture. In addition to the therapy of control group

treatment group was given Xiaoxuan Zhiyun tablet (1 dose/day

tid

). Both groups were treated for 3 weeks. Scores of cervical vertigo symptom and function assessment scale (ESCV) and vertigo disorder scale (DHI)

blood velocity of vertebrobasilar artery

life quality and efficacy were compared between both groups. Serum levels of superoxide dismutase (SOD)

malondialdehyde (MDA)

ET-1

5-HT and NO were detected in both groups.

Result:

After treatment

ESCV score of treatment group was obviously higher

while DHI score was lower than control group (

0.01). Blood flow velocity of left vertebral artery

right vertebral artery and basilar artery in treatment group were obviously higher than those of control group after treatment (

0.01). Total clinical efficacy of treatment group wsa 98.25%

which was superior to 83.93% of control group (

0.05). After treatment

SF-36 index score was remarkably higher than that of control group (

0.01). Serum levels of SOD and NO of treatment group were higher

while MDA

ET-1

5-HT were lower than control group (

0.01).

Conclusion:

In addition to the routine therapy

the efficacy of Xiaoxuan Zhiyun tablet in treating cervical vertigo is significant

which may be related with regulation of oxidative stress and serum levels of ET-1

5-HT and NO.

关键词

Keywords

references

王权．红花黄色素联合电针对颈性眩晕患者血清CRP，肝功能及CGRP水平及临床疗效的影响 [J]. 辽宁中医杂志， 2016 , 43 ( 9 ): 1965 - 1967 .

胡小军，余长江，李俊，等．回阳针法治疗椎动脉狭窄颈性眩晕瘀血阻络证55例分析 [J]. 重庆医学， 2016 , 45 ( 16 ): 2265 - 2267,2282 .

李永凯．天麻素辅助针灸治疗颈性眩晕疗效及对血浆ET-1和CGRP水平的影响 [J]. 中国实验方剂学杂志， 2015 , 21 ( 12 ): 162 - 165 .

牛朝阳，琚保军，孙永强，等．泽泻汤加味治疗痰浊中阻型颈性眩晕54例临床观察 [J]. 中医杂志， 2012 , 53 ( 15 ): 1298 - 1300 .

范志勇，吴山，林应强，等．基于微观血瘀探讨血管内皮细胞损伤在颈性眩晕中的发病机制 [J]. 成都中医药大学学报， 2017 , 37 ( 3 ): 124 - 126 .

武倩，刘正淑，孙荣．消眩止晕片对椎基底供血不足型眩晕的临床药效研究 [J]. 中国社区医师， 2018 , 34 ( 13 ): 111 - 112 .

朱姝．消眩止晕片联合敏使朗治疗老年性眩晕疗效观察 [J]. 中西医结合中国民间疗法， 2017 , 25 ( 2 ): 62 .

黄家政，陈万群，郑振源．消眩止晕片对实验动物脑缺血影响的研究 [J]. 中国实验动物学杂志， 2002 , 12 ( 2 ): 105 - 108 .

吴悦．定眩止晕汤联合长春司汀治疗椎-基底动脉供血不足眩晕的疗效及其对氧化应激的影响 [J]. 中医药信息， 2017 , 34 ( 5 ): 70 - 74 .

卓大宏．中国康复医学 [M]. 北京：华夏出版社， 2003 ： 1148 .

蒋国强，李放．老年脊柱外科学 [M]. 北京：人民军医出版社， 2014 ： 144 - 153 .

中华中医药学会．中医内科常见病诊疗指南·中医病证部分 [M]. 北京：中国中医药出版社， 2008 ： 43 - 45 .

Jacobson G P , Newman C W. The development of dizziness handicap inventory [J]. Arch Otolaryngol Head Neck Surg , 1990 , 116 ( 11 ): 424 - 427 .

欧凤荣，刘扬，刘丹，等． SF-36量表在疾病生命质量谱构建中应用 [J]. 中国公共卫生， 2008 , 24 ( 12 ): 1213 - 1221 .

国家中医药管理局．中医病证诊断疗效标准 [M]. 南京：南京大学出版社， 1994 ： 37 - 38 .

王明明，黄雪珍，蔡圣朝．蔡圣朝治疗颈性眩晕临床经验 [J]. 江西中医药， 2017 , 48 ( 5 ): 22 - 24 .

冯诚，郭杨，董维，等．益气活血化痰法治疗颈性眩晕的研究进展 [J]. 中国中医基础医学杂志， 2016 , 22 ( 10 ): 1417 - 1419 .

敖勇，廖力勇，蔡丽．中西药结合治疗急性椎-基底动脉供血不足性眩晕症临床研究 [J]. 辽宁中医药大学学报， 2016 , 18 ( 5 ): 212 - 214 .

WEI L F , ZHANG H M , WANG S S , et al . Changes of MDA and SOD in brain tissue after secondary brain injury with seawater immersion in Rats [J]. Turk Neurosurg , 2016 , 26 ( 3 ): 384 - 388 .

张清德，曲忠森．眩晕宁对椎基底动脉供血不足患者血清SOD，MDA，血浆内皮素及一氧化氮的影响 [J]. 中国实用神经疾病杂志， 2010 , 13 ( 1 ): 6 - 8 .

Kypreos K E , Zafirovic S , Petropoulou P I , et al . Regulation of endothelial nitric oxide synthase and high-density lipoprotein quality by estradiol in cardiovascular pathology [J]. J Cardiovasc Pharmacol Ther , 2014 , 19 ( 3 ): 256 - 268 .

Wright E A , d'Esterre C D , Morrison L B , et al . Absolute cerebral blood flow infarction threshold for 3-Hour ischemia time determined with CT perfusion and 18 F-FFMZ-PET imaging in a porcine model of cerebral ischemia [J]. PLoS One , 2016 , 11 ( 6 ): e0158 - 157 .

Beg S A , Hansen-Schwartz J A , Vikman P J , et al . ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat [J]. J Cereb Blood Flow Metab , 2006 , 26 ( 6 ): 846 - 856 .

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