Advances in Studies on Chinese Materia Medica for Treatment of Sepsis Based on NF-κB Signal Pathway

Yu-lu MIAO; Wen-zhi ZHANG; Wen-xia ZHANG; Min FENG; Yong-hua YUE; Chun-xia NIE; Yan NI

doi:10.13422/j.cnki.syfjx.20190706

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Advances in Studies on Chinese Materia Medica for Treatment of Sepsis Based on NF-κB Signal Pathway

Review | 更新时间：2021-02-09

- Advances in Studies on Chinese Materia Medica for Treatment of Sepsis Based on NF-κB Signal Pathway
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 9, Pages: 214-220(2019)
- 作者机构：
  
  1.山西省中医药研究院，太原　 030045
  2.山西中医药大学，太原　 030619
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190706
  CLC： R2-0; R22; R285.5; R284.1
- Received：05 September 2018，
  
  Published Online：18 December 2018，
  
  Published：05 May 2019
- 稿件说明：
移动端阅览
Yu-lu MIAO, Wen-zhi ZHANG, Wen-xia ZHANG, et al. Advances in Studies on Chinese Materia Medica for Treatment of Sepsis Based on NF-κB Signal Pathway[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(9): 214-220.
DOI：

Yu-lu MIAO, Wen-zhi ZHANG, Wen-xia ZHANG, et al. Advances in Studies on Chinese Materia Medica for Treatment of Sepsis Based on NF-κB Signal Pathway[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(9): 214-220. DOI： 10.13422/j.cnki.syfjx.20190706.

摘要

脓毒症是由感染、手术、创伤等引起的全身炎症反应综合征(SIRS)，死亡率高、治疗费用高、医疗资源消耗大，给医疗行业甚至是国家经济都带来了很大的负担，因此，找到治疗脓毒症的有效措施刻不容缓。目前针对脓毒症的发病机制，使用了一定的药物治疗，抗生素、糖皮质激素、血管活性药物等，但其治疗效果并不理想，副作用多，预后效果差，临床死亡率依然居高不下。中医讲究整体观念，辨证论治，对于脓毒症的治疗具有功效独特、副作用相对较小等优势，吸引了无数来自世界各地有志于解决脓毒症的科研及临床工作者们的目光。近年来，一些中药复方、中成药、单味中药及活性成分越来越多的作为新型药物用于预防、治疗脓毒症，并且得到了广泛的认可，在一定程度上降低了脓毒症患者的死亡率、炎性指标等，对于脓毒症的治疗起到了重要的作用。本文就核转录因子-

B(NF-

B)信号通路在脓毒症中的作用及以NF-

B信号通路相关蛋白为作用靶点的中药治疗脓毒症的研究进展进行综述。

Abstract

Sepsis is a kind of systemic inflammatroy response syndrome (SIRS) induced by severe infection

operation

and trauma

with high mortality rate

treatment cost

and high consumption of medical resources. It has caused a great burden to the medical industry and even the national economy. Therefore

it is urgent to find effective treatment methods for sepsis. At present

the sepsis has been treated with certain drugs pointing at its pathogenesis

such as antibiotics

glucocorticoids

and vasoactive drugs.

but the therapeutic effect is not ideal

with many side effects

poor prognosis

and high clinical mortality. Based on the overall macro-dialectical thinking mode

and with the unique effect and low side effect

traditional Chinese medicine (TCM) has attracted the attention from researchers and clinicians around the world for treatment of sepsis. In recent years

some traditional Chinese medicine prescriptions

Chinese patent medicines

single Chinese medicines and active ingredients are increasingly used as new drugs to prevent and treat sepsis. Such treatment methods have been widely recognized and have reduced the mortality and inflammatory indexes of patients to a certain extent

playing an important role in the prevention and treatment of sepsis. In this paper

the actions of nuclear factor kappa B(NF-

B) signal pathway in sepsis as well as the advances in research of NF-

B signal pathway-related proteins in Chinese medicine for sepsis were reviewed.

关键词

Keywords

references

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