Application of Quantitative Analysis of Multi-components by Single Marker in Quality Control of Chinese Medicinal Materials Containing Saponins

Ze-jun ZHANG; Xiu-ming CUI; Li-juan CHEN; Yu-piao HU; Yi-ming ZHANG; Yin XIONG

doi:10.13422/j.cnki.syfjx.20190716

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Application of Quantitative Analysis of Multi-components by Single Marker in Quality Control of Chinese Medicinal Materials Containing Saponins

Review | 更新时间：2021-02-09

- Application of Quantitative Analysis of Multi-components by Single Marker in Quality Control of Chinese Medicinal Materials Containing Saponins
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 8, Pages: 210-218(2019)
- 作者机构：
  
  1.昆明理工大学　生命科学与技术学院，昆明　 650500；
  2.云南省三七资源可持续利用重点实验室，昆明　 650500；
  3.国家中医药管理局　三七资源可持续发展利用研究室，昆明　 650500
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190716
  CLC： R284.2;R289;R22;R2-031
- Received：24 May 2018，
  
  Published Online：19 December 2018，
  
  Published：20 April 2019
- 稿件说明：
移动端阅览
Ze-jun ZHANG, Xiu-ming CUI, Li-juan CHEN, et al. Application of Quantitative Analysis of Multi-components by Single Marker in Quality Control of Chinese Medicinal Materials Containing Saponins[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 210-218.
DOI：

Ze-jun ZHANG, Xiu-ming CUI, Li-juan CHEN, et al. Application of Quantitative Analysis of Multi-components by Single Marker in Quality Control of Chinese Medicinal Materials Containing Saponins[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 210-218. DOI： 10.13422/j.cnki.syfjx.20190716.

摘要

因中药多成分、多靶点的特征，采用关联中药药效活性的多指标成分定性定量较单一指标更能合理表征中药质量，同时由于对照品不稳定、昂贵不易获得等特点也使多指标评控模式难以普及。皂苷是苷元为三萜或螺旋甾烷类化合物的一类糖苷，其广泛分布于植物界并是许多中药的主要活性成分，具有抗肿瘤、免疫调节、抗病毒、防治心血管疾病等作用。如何对含皂苷类成分的中药进行合理有效的质量控制，对于保证此类中药的临床安全有效性具有重要意义。一测多评(quantitative analysis of multi-components by single marker

QAMS)法是只用一种对照品来实现对中药中多个成分的同步监控，能有效避免多指标评控模式存在的问题，该方法自提出至今十多年已经在中药质量控制和评价中得到较好的发展和验证，并在含皂苷类成分中药的质量控制中应用广泛。该文在阐述QAMS法原理的基础上结合近10年文献，对QAMS法在含三萜皂苷和甾体皂苷类成分中药及其制剂中的质控研究进行系统梳理及论述，并对可能存在的问题进行分析阐释，以期为该方法在中药质控领域的持续深入发展提供参考。

Abstract

Due to the multi-component and multi-target features of Chinese medicinal materials (CMMs)

multiple active components could be more reasonably represent the quality of CMMs compared with the single-component QC mode. However

it is still difficult to apply the multi-component QC mode because of the instability

high cost and inaccessibility of reference substances of CMMs. Saponins are glycosides with aglycones of triterpene or spirostane and widely distributed in plants. Saponins are also the major active constituents of many CMMs

with multi-effects of inhibiting tumors

regulating the immune system

inhibiting virus

preventing and treating cardiovascular diseases. Therefore

rational and effective control of the quality of CMMs containing saponins is of great significance for ensuring the clinical safety and efficacy of such CMMs and related products. The quantitative analysis of multi-components by single marker (QAMS) can use only one reference substance to achieve the simultaneous monitoring of multiple components in CMMs

and make up the weaknesses of multi-component QC mode

and has been well developed and validated in the QC and evaluation of CMMs for more than ten years since it was put forward. And now it has been widely used in the QC of CMMs containing saponins. Based on the investigation of QAMS theory and literatures in the past decade

studies on the QC of CMMs and related preparations containing triterpenoid saponins and steroidal saponins by QAMS were summarized and discussed systematically. In addition

some possible problems were analyzed and interpreted

in order to provide reliable basis for more QC of CMMs and reference for the continuous use and in-depth development of this method in the research of CMMs.

关键词

Keywords

references

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