Effect of Shoutaiwan and Shaoyao Gancao Tang on Recurrent Spontaneous Abortion

Yan-li SONG; Ai-wu WEI; Zi-xue SUN; Bo MEN; Hua ZHANG

doi:10.13422/j.cnki.syfjx.20190727

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Effect of Shoutaiwan and Shaoyao Gancao Tang on Recurrent Spontaneous Abortion

Classic Prescriptions | 更新时间：2021-02-09

- Effect of Shoutaiwan and Shaoyao Gancao Tang on Recurrent Spontaneous Abortion
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 7, Pages: 36-42(2019)
- 作者机构：
  
  1.河南省中医院，郑州　 450002；
  2.河南中医药大学　第一附属医院，郑州　 450009
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190727
  CLC： R22;R242;R2-031;R287
- Received：04 September 2018，
  
  Published Online：20 December 2018，
  
  Published：05 April 2019
- 稿件说明：
移动端阅览
Yan-li SONG, Ai-wu WEI, Zi-xue SUN, et al. Effect of Shoutaiwan and Shaoyao Gancao Tang on Recurrent Spontaneous Abortion[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(7): 36-42.
DOI：

Yan-li SONG, Ai-wu WEI, Zi-xue SUN, et al. Effect of Shoutaiwan and Shaoyao Gancao Tang on Recurrent Spontaneous Abortion[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(7): 36-42. DOI： 10.13422/j.cnki.syfjx.20190727.

摘要

目的：

观察寿胎丸合芍药甘草汤加味对复发性流产脾肾气虚证患者的影响，探讨其作用机制。

方法：

将180例符合条件的患者随机分为对照组和治疗组，各90例。在淋巴细胞免疫治疗基础上，对照组给予地屈孕酮片，观察组给予寿胎丸合芍药甘草汤加味。观察组患者凝血功能[部分纤溶酶原激活物抑制剂-1(PAI-1)，纤维蛋白原(FIB)，组织型纤溶酶原活化因子(t-PA)，凝血酶原时间(PT)，

-二聚体(

-D)，组织因子(TF)，纤维蛋白肽A(FPA)，纤维蛋白原(Fig)，

颗粒膜糖蛋白-140(GMP-140)，纤溶酶-抗纤溶酶复合物(PAP)，血小板血酶-抗凝血酶复合物(TAT)]，血清封闭抗体(CD3

＋

，CD4

＋

，CD8

＋

，CD4

＋

/CD8

＋

)，炎性因子[

-干扰素(IFN-

)，肿瘤坏死因子-

(TNF-

)，白细胞介素-1

(IL-1

)，白细胞介素-10(IL-10)]水平和中医辨证“数堕胎”脾肾气虚证评分；比较两组患者足月分娩率和不良反应发生率。

结果：

研究期间脱落5例，治疗组足月分娩率92.0%，高于对照组的73.6%（

0.05）。治疗组总有效率97.7%，高于对照组的81.6%（

0.05）。治疗组患者的凝血功能指标（PAI-1

FIB

t-PA

D-D

PAP

GMP-140

TAT），封闭抗体（CD3

＋

CD4

＋

，CD4

＋

/CD8

＋

），炎症因子（IFN-

，TNF-

，IL-1

）和中医证候评分较对照组明显降低（

0.05）；凝血功能指标（PT，TF，FPA，Fig），血清封闭抗体CD8

＋

和炎症因子IL-10较对照组明显升高（

0.05）。治疗组不良反应发生率10.3%（9/87）低于对照组的22.7%（20/88）（

0.05）。

结论：

寿胎丸合芍药甘草汤加味可有效提高复发性流产脾肾气虚证患者的足月分娩率，明显改善其中医证候的评分、凝血功能、血清封闭抗体，炎性因子水平，降低淋巴细胞免疫治疗的不良反应。

Abstract

Objective:

To observe the effect of Shoutaiwan and Shaoyao Gancao Tang on recurrent spontaneous abortion due to spleen and kidney Qi deficiency.

Method:

Totally 80 eligible patients were randomly divided into the control group and the treatment group

with 90 cases in each group. The control group was treated with lymphocyte immune; the Shoutaiwan and Shaoyao Gancao Tang combined with lymphocyte immune was applied in the treatment group. Coagulation function [the part plasminogen activator inhibitor-1 (PAI-1)

fibrinogen (FIB)

type plasminogen activator (t-PA)

prothrombin time (PT)

-dimer (D-D) and tissue factor (TF)

fibrin peptide A (FPA)

fibrinogen (Fig)

Plasminase-antifibrinolytic complex (PAP)

glycoprotein platelet particle-140 (GMP-140)

thrombin-antithrombin complex (TAT)]

serum closed antibody (CD3

CD4

CD8

CD4

/CD8

)

inflammatory factor interferon-

(IFN-

)

tumor necrosis factor-

(TNF-

)

Interleukin-1

(IL-1

)

interleukin-10 (IL-10)]were scored after the treatment. The rates of birth and adverse reactions in each group were compared. The traditional Chinese medicine(TCM) syndrome differentiation of abortion spleen and kidney Qi deficiency was scored.

Result:

5 cases were lost during the study period. The term delivery rate was 92.0%in the treatment group

which was higher than 73.6%in control group (

0.05). The total effective rate was 97.7%in the treatment group

which was higher than 81.6%in control group (

0.05). The coagulation function indexes (PAI-1

FIB

t-PA

D-D

PAP

GMP-140

TAT)

closed antibodies (CD3

CD4

/CD8

)

inflammatory factors (IFN-

TNF-

IL-1

) and TCM syndrome scores were significantly lower in the treatment group than that in control group (

0.05). Coagulation function indexes (PT

FPA

Fig)

serum blocking antibodies (CD8

)

inflammatory factors IL-10 were significantly increased compared with the control group (

0.05). The incidence of adverse reactions in treatment group was 10.3%(9/87)

which was lower than 22.7%in control group (20/88) (

0.05).

Conclusion:

Shoutaiwan and Shaoyao Gancao Tang have a remarkable effect on recurrent spontaneous abortion case by spleen and kidney Yang deficiency.

关键词

Keywords

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