Effect of Longdan Xiegantang on Serum Inflammatory Factors, Related Proteins and Immune Function in Patients with Secretory Otitis Media

Rui WEI; Yan-hong YUAN; Lu-lu CHEN; Hui-min WANG; Da-jing XIONG

doi:10.13422/j.cnki.syfjx.20190728

您当前的位置：

首页 >

文章列表页 >

Effect of Longdan Xiegantang on Serum Inflammatory Factors, Related Proteins and Immune Function in Patients with Secretory Otitis Media

Classic Prescriptions | 更新时间：2021-02-09

- Effect of Longdan Xiegantang on Serum Inflammatory Factors, Related Proteins and Immune Function in Patients with Secretory Otitis Media
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 8, Pages: 14-19(2019)
- 作者机构：
  
  1.河南省中医院，郑州　 450002；
  2.成都中医药大学，成都　 611130
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190728
  CLC： R22;R242;R2-031;R287
- Received：08 October 2018，
  
  Published Online：20 December 2018，
  
  Published：20 April 2019
- 稿件说明：
移动端阅览
Rui WEI, Yan-hong YUAN, Lu-lu CHEN, et al. Effect of Longdan Xiegantang on Serum Inflammatory Factors, Related Proteins and Immune Function in Patients with Secretory Otitis Media[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 14-19.
DOI：

Rui WEI, Yan-hong YUAN, Lu-lu CHEN, et al. Effect of Longdan Xiegantang on Serum Inflammatory Factors, Related Proteins and Immune Function in Patients with Secretory Otitis Media[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 14-19. DOI： 10.13422/j.cnki.syfjx.20190728.

摘要

目的：

探究龙胆泻肝汤对肝胆湿热型分泌性中耳炎(SOM)的血清炎性因子、相关蛋白及免疫功能的影响。

方法：

随机将2017年7月至2018年5月河南省中医院收治的76例肝胆湿热型SOM患者分为两组患者，各38例，对照组采用曲安奈德和氨溴索进行治疗，在对照组的基础上，观察组给予龙胆泻肝汤水煎服。于治疗前后，观察两组患者的免疫球蛋白(Ig)A

IgG

IgM

CD3

CD4

CD8

NK，白细胞介素-1

(IL-1

)

IL-5

IL-8，肿瘤坏死因子-

(TNF-

)，血小板活化因子(PAF)，降钙素原(PCT)，水通道蛋白-1(AQP-1)

AQP-4，纤维连接蛋白(Fn)，可溶性白细胞介素-2受体(SIL-2R)水平，并观察两组患者的疗效、不良反应。

结果：

①疗效，治疗后观察组治疗总有效率为92.11%，高于对照组的76.32%(

=2.108，

0.05)。②血清炎性介质，观察组治疗后TNF-

PAF

PCT

IL-1

IL-8水平低于对照组(

0.05)。③血清相关蛋白，观察组治疗后SIL-2R水平低于对照组(

0.05)，观察组治疗后AQP-1

AQP-4

Fn水平高于对照组(

0.05)。④细胞及体液免疫功能，观察组治疗后CD8

IgA

IgG

IgM低于对照组(

0.05)

CD3

CD4

/CD8

NK高于对照组(

0.05)。⑤不良反应，两组患者发生率分别为7.89%，10.53%，组间差异无统计学意义。

结论：

龙胆泻肝汤治疗肝胆湿热型SOM效果显著，能恢复症状，抑制炎症反应，激活细胞和体液免疫功能系统，降低AQP-1，SIL-2R等蛋白分泌，提高AQP-4，Fn蛋白分泌。

Abstract

Objective:

To explore the effect of Longdan Xiegantang on serum inflammatory factors

related proteins and immune function in patients of secretory otitis media (SOM) with liver and gallbladder wetness-heat Syndrome.

Method:

Totally 76 cases of SOM with liver and gallbladder wetness-heat syndrome admitted to our hospital from July 2017 to May 2018 were randomly divided into two groups

with 38 cases in each group. Control group was treated with triamcinolone acetonide and ambroxol. In addition to the therapy of control group

observation group was also treated with Longdan Xiegantang. Immunoglobulin (Ig) A

IgG

IgM

CD3

CD4

CD8

and NK

interleukin-1 beta (IL-1

)

IL-5

IL-8

tumor necrosis factor-

(TNF-

)

platelet activating factor (PAF)

calcitonin (PCT) and water channel protein-1 (AQP-1)

AQP-4

fiber link protein (Fn) and soluble interleukin-2 receptor (SIL-2R) levels of two groups were observed before and after treatment. Curative effect and adverse reaction were observed.

Result:

①Curative effect

after treatment

the total effective rate of observation group was 92.11%

which was higher than 76.32%of control group

with statistically significant differences (

=2.108

0.05). ②Serum inflammatory medium

TNF-

PAF

PCT

IL-1

and IL-8 in observation group were lower than those in control group after treatment (

0.05). ③Serum related proteins

in observation group

levels of SIL-2R were lower than those of control group (

0.05)

while the levels of AQP-1

AQP-4 and Fn were higher than those of control group (

0.05). ④Cellular and humoral immunity

CD8

IgA

IgG and IgM of observation group were lower than those of control group (

0.05)

while CD3

CD4

/CD8

and NK were higher than those of control group (

0.05). ⑤Adverse reactions

the incidence rates of the two groups were 7.89%and 10.53%

respectively

with no statistically significant difference between two groups.

Conclusion:

Longdan Xiegantang has a remarkable effect in treating patients of secretory otitis media with liver and gallbladder wetness-heat syndrome

and can restore symptoms

inhibit inflammatory response

activate cell and humeral immune system

reduce the secretion of AQP-1

SIL-2R and other proteins

and increase the secretion of AQP-4 and Fn proteins.

关键词

Keywords

references

Alper C M , Teixeira M S , Swarts J D. Eustachian tube function in adults with ventilation tubes inserted for otitis media with effusion [J]. J Int Adv Otol , 2018 , 14 ( 2 ): 255 - 262 .

Dewan K , Lieu J. A clinical trial of proton pump inhibitors to treat children with chronic otitis media with effusion [J]. J Int Adv Otol , 2018 , 14 ( 2 ): 245 - 249 .

刘凤杰．分泌性中耳炎病因与治疗新进展 [J]. 临床医药文献电子杂志， 2018 , 5 ( 35 ): 12 - 13 .

王颖．分泌性中耳炎的中西医治疗进展 [J]. 中医耳鼻喉科学研究， 2018 , 17 ( 1 ): 4 - 6 .

王丽丽．中医药治疗分泌性中耳炎进展研究 [J]. 中医耳鼻喉科学研究， 2009 , 8 ( 3 ): 3 - 5,21 .

刘霞，钟凤如，马和平，等．氨溴索辅助治疗分泌性中耳炎对患者局部和全身炎症介质水平的影响 [J]. 现代医院， 2017 , 17 ( 10 ): 1504 - 1506 .

王维安，许珉．曲安奈德治疗急性分泌性中耳炎的临床疗效及对机体免疫功能的影响 [J]. 临床医学研究与实践， 2018 , 3 ( 22 ): 75 - 76,83 .

刘教练，蔡继红．通窍胶囊联合布地奈德对分泌性中耳炎患者听力及血清AQP-1、AQP-4水平的影响 [J]. 广西医科大学学报， 2017 , 34 ( 12 ): 1775 - 1777 .

严斌，吴文文，刘博，等．氨溴索联合雷诺考特鼻喷雾剂对分泌性中耳炎患者血清与耳积液HA sIL-2R Fn炎性介质的影响 [J]. 河北医学， 2018 , 24 ( 5 ): 782 - 786 .

张义．地塞米松联合盐酸氨溴索可有效治疗分泌性中耳炎 [J]. 基因组学与应用生物学， 2018 , 37 ( 1 ): 178 - 184 .

黄选兆，汪吉宝．实用耳鼻咽喉科学 [M]. 北京：人民卫生出版社， 2014 ： 852 - 853 .

王士贞．中医耳鼻咽喉科学 [M]. 北京：中国中医药出版社， 2003 ： 58 - 59 .

刘娅，杨军，张杰，等．临床实践指南：分泌性中耳炎(更新版) [J]. 听力学及言语疾病杂志， 2016 , 24 ( 5 ): 499 - 519 .

Francis N A , Cannings-John R , Waldron C A , et al . Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial [J]. Lancet , 2018 , 392 ( 10147 ): 557 - 568 .

Bandyopadhyay T , Raman E V. Otitis media with effusion (OME) in urban pediatric population in a tertiary care centre: a clinical study [J]. Indian J Otolaryngol Head Neck Surg , 2018 , 70 ( 2 ): 267 - 272 .

王挺．龙胆泻肝汤加减合中耳炎散治疗分泌性中耳炎肝胆湿热型疗效观察 [J]. 实用中医药杂志， 2018 , 34 ( 8 ): 910 - 911 .

王丹凤．龙胆泻肝汤治疗分泌性中耳炎肝胆湿热型临床研究 [J]. 实用中医药杂志， 2018 , 34 ( 2 ): 159 - 160 .

王皓，于向阳，郭琳，等．龙胆泻肝汤治疗分泌性中耳炎肝胆湿热型60例 [J]. 河南中医， 2011 , 31 ( 1 ): 79 - 80 .

谢晓兴，熊高云，戈言平，等．分泌性中耳炎患者的血清及中耳积液内炎性因子和转化生长因子水平检测及其临床价值分析 [J]. 中华全科医学， 2018 , 16 ( 9 ): 1449 - 1451,1478 .

黄坤平，李湘，王颖菁，等．白三烯受体拮抗联合中药治疗分泌性中耳炎临床研究及对耳积液和血清sIL-2R、Fn影响 [J]. 辽宁中医药大学学报， 2017 , 19 ( 8 ): 140 - 143 .

霍炳杰，常靓，刘羽，等．耳聋左慈丸合通气散治疗慢性分泌性中耳炎的疗效及对血清水通道蛋白1及4水平的影响 [J]. 中国实验方剂学杂志， 2016 , 22 ( 12 ): 191 - 194 .

文凤妮，黄文柱，陆扬光，等．龙胆泻肝胶囊对肝胆湿热型分泌性中耳炎患者PAF, ET-1含量的影响 [J]. 中国实验方剂学杂志， 2016 , 22 ( 10 ): 158 - 161 .

马芳，郭月婷，刘江涛，等．通窍化瘀方与针刺结合常规西医治疗对分泌性中耳炎患者耳积液和血清相关因子水平(sIL-2R及Fn)的影响 [J]. 医疗装备， 2016 , 29 ( 8 ): 15 - 16 .

袁萍．血清及耳积液多项细胞因子与中耳炎的关系 [J]. 海南医学院学报， 2014 , 20 ( 12 ): 1736 - 1738 .

杜冬琛．中西医结合治疗慢性肾衰竭的效果及对血清FN、PAI-1水平变化的影响 [J]. 中华中医药学刊， 2018 , 36 ( 8 ): 2005 - 2007 .

更藏达杰，毛海明．分泌性中耳炎患者炎性因子、细胞免疫及体液免疫功能分析 [J]. 海南医学院学报， 2018 , 24 ( 16 ): 1529 - 1531 .

柳荫，杨娜．腺样体肥大并发分泌性中耳炎儿童的淋巴细胞亚群分布 [J]. 实用医学杂志， 2017 , 33 ( 14 ): 2376 - 2379 .

迟作华，刘振，肖平． NK细胞及IL-2、IL-4、IFN- γ 在上呼吸道感染诱发急性分泌性中耳炎患者的表达 [J]. 中国实验诊断学， 2014 , 18 ( 6 ): 973 - 975 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Wenyang Huashi Prescription on Inflammatory Factors and Immune Function of Patients After Allergic Fungal Rhinosinusitis

Clinical Efficacy and Mechanism of Longdan Xiegantang in Treatment of Pelvic Inflammatory Infertility

Effect of Rhei Radix et Rhizoma Before and After Steaming with Wine on Intestinal Flora and Immune Environment in Constipation Model Mice

Effects of Jianpi Bushen Prescription on Hematopoiesis and Immune System in Tumor Patients After Radiotherapy

Curative Effect and Mechanism of Traditional Chinese Medicine in Treatment of Diabetic Gastroenteropathy： A Review

Related Author

Yong-wen LI

Jing-bo LI

Jun-jie WANG

Jiao LI

Jie LIN

BAI Yaya

TIAN Rui

SHI Yajun

Related Institution

Henan Province Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Chinese Medicine)

The First Hospital of Hunan University of Chinese Medicine

Shaanxi Engineering Technology Research Center of Chinese Herbal Pieces，Shaanxi Qinling Application Development and Engineering Research Center of Chinese Herbal Medicine，Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine（TCM） for TCM Compatibility， Shaanxi University of Chinese Medicine，Xi′an

Hanlin College，Nanjing University of Chinese Medicine

Hubei University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰