Clinical Effect of Acupoint Application Therapy of Modified Wuzhuyu Binglang Tang on Chronic Non-atrophic Gastritis

Xiao-lei JING; Yong-qin ZHANG; Ya-jiao GU; Jing-lan FEI

doi:10.13422/j.cnki.syfjx.20190729

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Clinical Effect of Acupoint Application Therapy of Modified Wuzhuyu Binglang Tang on Chronic Non-atrophic Gastritis

Clinic | 更新时间：2021-02-09

- Clinical Effect of Acupoint Application Therapy of Modified Wuzhuyu Binglang Tang on Chronic Non-atrophic Gastritis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 12, Pages: 104-109(2019)
- 作者机构：
  
  1.河南中医药大学　护理学院，郑州　 450000;
  2.河南中医药大学　第一附属医院，郑州　 450003
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190729
  CLC： R22; R242; R2-031; R287
- Received：09 October 2018，
  
  Published Online：20 December 2018，
  
  Published：20 June 2019
- 稿件说明：
移动端阅览
Xiao-lei JING, Yong-qin ZHANG, Ya-jiao GU, et al. Clinical Effect of Acupoint Application Therapy of Modified Wuzhuyu Binglang Tang on Chronic Non-atrophic Gastritis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(12): 104-109.
DOI：

Xiao-lei JING, Yong-qin ZHANG, Ya-jiao GU, et al. Clinical Effect of Acupoint Application Therapy of Modified Wuzhuyu Binglang Tang on Chronic Non-atrophic Gastritis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(12): 104-109. DOI： 10.13422/j.cnki.syfjx.20190729.

摘要

目的：

观察吴茱萸槟榔汤加减穴位贴敷对慢性非萎缩性胃炎(CNAG)的疗效及作用机制。

方法：

将217例患者采用SAS软件生成，随机分为对照组(107例)和观察组(110例)。基础治疗，奥美拉唑肠溶片，20 mg/次，2次/d，饭前半小时口服；枸橼酸铋钾片，2片/次，2次/d，饭前半小时口服；阿莫西林胶囊，1.0 g/次，2次/d，饭后即服，二维呋喃唑酮片，1片/次，2次/d，饭后即服；枸橼酸莫沙必利片，5 mg/次，3次/d，口服；连续服用2周。观察组采用吴茱萸槟榔汤加减贴敷中脘、胃俞、膈俞、神阙、脾俞等穴位，持续6 h/d，每日1次。对照组采用模拟药物贴敷同样穴位。两组连续治疗2周。进行治疗前后胃脘痞满、胃脘疼痛等消化不良症状评分；检测治疗前后胃动素、胃泌素、肿瘤坏死因子-

(TNF-

)，白细胞介素-6(IL-6)和前列腺素E

(PGE

)水平；随访1个月后复查胃镜和幽门螺杆菌(Hp)检测；记录两组患者穴位贴敷出现的不良反应。

结果：

观察组患者胃镜疗效优于对照组(

＝2.015，

0.05)，观察组患者中医证候疗效优于对照组(

＝2.663，

0.01)；观察组胃脘痞满、胃脘疼痛、食后腹胀、早饱、纳呆、呃逆、泛酸、暖气、恶心呕吐等消化不良症状评分均低于对照组(

0.01)；观察组Hp阴转率为93.64%，高于对照组的84.11%(

＝5.002，

0.05)；观察组患者血清TNF-

，IL-6水平均低于对照组，PGE

水平高于对照组(

0.01)；观察组患者胃动素和胃泌素水平均高于对照组(

0.01)；观察组6例患者出现轻度红斑、瘙痒，作对症处理后消失。

结论：

采用吴茱萸槟榔汤加减穴位贴敷辅助治疗CNAG患者可显著减轻临床症状，促使HP阴转，提高临床疗效，并能调节胃肠激素和抑制炎症因子释放，起到保护胃黏膜，改善胃肠功能的作用，临床使用安全。

Abstract

Objective:

To observe the effect of acupoint application therapy of modified Wuzhuyu Binglang Tang on chronic non-atrophic gastritis (CNAG) and the mechanism of action.

Method:

Two hundred and seventeen patients were randomly divided into control group (107 cases) and observation group (110 cases) by random number table. Both groups’ patients got Omeprazole enteric-coated tablets half an hour before meals

20 mg/time

2 times/day

bismuth potassium citrate tablets half an hour before meals

2 tablets/time

2 times/day

amoxicillin capsules after meals

1.0 g/time

2 times/day

two dimensional furazolidone tablets after meals

1 tablet/time

2 times/day

mosapride citrate tablets

5 mg/time

3 times/day. The treatment lasted for 2 weeks. Patients in observation group got acupoint application of modified Wuzhuyu Binglang Tang at Zhongwan

Weiyu

Geyu

Shenyu and Piyu for 6 h/day

1 time/day. And the patients in control group got model drug at the same acupoints. Before and after treatment

epigastric fullness and epigastric pain were scored. Levels of motilin

gastrin

tumor necrosis factor-

(TNF-

)

interleukin-6 (IL-6) and prostaglandin E

(PGE

) were detected. In 1-month follow-up visit

Hp and adverse reaction were detected under gastroscope.

Result:

The clinical effect in observation group under gastroscope was better than that in control group (

=2.015

0.05)

and the scores of traditional Chinese medicine symptoms in observation group was better than those in control group (

=2.663

0.01). And scores of epigastric fullness

epigastric pain

post-food abdominal distention

early satiety

nausea

hiccup

pantothenic acid

heating

nausea and vomiting were lower than those in control group (

0.01). The negative conversion rate of Hp in observation group was 93.64%

which was higher than 84.11%in control group (

=5.002

0.05). And levels of TNF-α and IL-6 were lower than those in control group

PGE

was higher than that in control group (

0.01). And mild erythema and itching disappeared after symptomatic treatment.

Conclusion:

The acupoint application therapy of modified Wuzhuyu Binglang Tang can relieve the clinical symptoms

promote the negative conversion rate of Hp

improve the clinical effect

regulate gastrointestinal hormones

inhibiting release of inflammatory factors

protect gastric mucosa

and improve gastrointestinal function

with safety in clinic use.

关键词

Keywords

references

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