Jie WANG, Guang CHEN. Coronary Heart Disease Phlegm-blood Stasis-stagnation-deficiency Innovation Theory and Clinical Application Based on Complex System[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(1): 11-15.
DOI:
Jie WANG, Guang CHEN. Coronary Heart Disease Phlegm-blood Stasis-stagnation-deficiency Innovation Theory and Clinical Application Based on Complex System[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(1): 11-15. DOI: 10.13422/j.cnki.syfjx.20190750.
Coronary Heart Disease Phlegm-blood Stasis-stagnation-deficiency Innovation Theory and Clinical Application Based on Complex System
There exits a trend of treatment for coronary heart disease(CHD) in terms of Chinese medicine(CM) in history
from warming Yang and dispelling cold
moving Qi and dissolving phlegm to invigorating blood and dissolving stasis
whose time-space development accords to the theory of complex system.Targeting the contemporary population of CHD
phlegm-blood stasis-stagnation-deficiency theory is proposed to direct clinical application to further improve effectiveness.From the perspective of theory
blood stasis-stagnation is the basic pathogenesis of CHD that runs through the whole period in the advance of CHD
while phlegm has been changing the feature of CM Zheng of CHD population with the development of the society
and nourishing the body according to the type of deficiency might delay the process of growing older
postpone the occur of disease and hinder the advance of disease
which genuinely differs from modern medicine to render the superiority of CM to work out the challenges of CHD.As for the clinical application
the treatment options could consider invigorating blood
dissolving stasis and removing stagnation as the basic method
such as CHD formula 2
Xuefu Zhuyutang
Zhizi Chitang and Danggui Niantongtang could be used in varied period of CHD.Moreover
boosting the body by herbal medicine could regulate the routine of body
then to prevent CHD and fear down the advance of CHD
for instance
Codonopsis Radix
Astragali Radix
Liuwei Dihuang pills
Zuoguiyin and Youguiyin.Furthermore
balmiest herbs could not only dissolve phlegm
unblock the meridian and relieve pain
but also calm the mind and eliminate the anxiety.For example
Aquilariae Lignum Resinatum
Santali Albi Lignum and Moschus could be used handily in the treatment of CHD.
O'Gara P T , Kushner F G , Ascheim D D ,et al . 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction:a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines [J]. J Am Coll Cardiol , 2013 , 61 ( 4 ): e78 - e140 .
Whelton P K , Carey R M , Aronow W S ,et al . 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention,detection,evaluation,and management of high blood pressure in adults:a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines [J]. Circulation , 2018 , 138 ( 17 ): e484 - e594 .
International Diabetes Federation Guideline Development Group . Global guideline for type 2 diabetes [J]. Diabetes Res Clin Pract , 2014 , 104 ( 1 ): 1 - 52 .
Robinson J G , Stone N J. The 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk:a new paradigm supported by more evidence [J]. Eur Heart J , 2015 , 36 ( 31 ): 2110 - 2118 .
Fouquerel E , Lormand J , Bose A ,et al . Oxidative guanine base damage regulates human telomerase activity [J]. Nat Struct Mol Biol , 2016 , 23 ( 12 ): 1092 - 1100 .
Kubben N , ZHANG W , WANG L ,et al . Repression of the antioxidant NRF2 pathway in premature aging [J]. Cell , 2016 , 165 ( 6 ): 1361 - 1374 .
PAN C , LOU L , HUO Y ,et al . Salvianolic acid B and tanshinone Ⅱ A attenuate myocardial ischemia injury in mice by NO production through multiple pathways [J]. Ther Adv Cardiovasc Dis , 2011 , 5 ( 2 ): 99 - 111 .
XU W , YANG J , WU L M. Cardioprotective effects of tanshinone Ⅱ A on myocardial ischemia injury in rats [J]. Pharmazie , 2009 , 64 ( 5 ): 332 - 336 .
Maione F , Cantone V , Chini M G ,et al . Molecular mechanism of tanshinone Ⅱ A and cryptotanshinone in platelet anti-aggregating effects:an integrated study of pharmacology and computational analysis [J]. Fitoterapia , 2015 , 100 : 174 - 178 .
ZHOU Z Y , HUANG B , LI S ,et al . Sodium tanshinone Ⅱ A sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish [J]. Toxicol Appl Pharmacol , 2018 , 350 : 32 - 42 .
ZHAO D , TONG L , ZHANG L ,et al . Tanshinone Ⅱ A stabilizes vulnerable plaques by suppressing RAGE signaling and NF- κ B activation in apolipoprotein-E-deficient mice [J]. Mol Med Rep , 2016 , 14 ( 6 ): 4983 - 4990 .
HU H , ZHAI C , QIAN G ,et al . Protective effects of tanshinone Ⅱ A on myocardial ischemia reperfusion injury by reducing oxidative stress,HMGB1 expression, and inflammatory reaction [J]. Pharm Biol , 2015 , 53 ( 12 ): 1752 - 1758 .
LIU C , WANG J , YANG J. Study on activating blood and eliminating stasis of total paeony glycoside(TPG) [J]. J Chin Med Mater , 2000 , 23 ( 9 ): 557 - 560 .
LONG J , GAO M , KONG Y ,et al . Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats [J]. Phytomedicine , 2012 , 19 ( 8/9 ): 672 - 676 .
LI J , CHEN C X , SHEN Y H. Effects of total glucosides from paeony( Paeonia lactiflora Pall) roots on experimental atherosclerosis in rats [J]. J Ethnopharmacol , 2011 , 135 ( 2 ): 469 - 475 .
Kim E Y , Kim J H , Rhyu M R. Endothelium-independent vasorelaxation by Ligusticum wallichii in isolated rat aorta:comparison of a butanolic fraction and tetramethylpyrazine,the main active component of Ligusticum wallichii [J]. Biol Pharm Bull , 2010 , 33 ( 8 ): 1360 - 1363 .
Kim B , Kim J , Kim A ,et al . Ligusticum wallichi -induced vasorelaxation mediated by mitogen-activated protein kinase in rat aortic smooth muscle [J]. J Ethnopharmacol , 2004 , 90 ( 2/3 ): 397 - 401 .
PANG P K , SHAN J J , Chiu K W. Tetramethylpyrazine,a calcium antagonist [J]. Planta Med , 1996 , 62 ( 5 ): 431 - 435 .
Kim E Y , Rhyu M R. Synergistic vasorelaxant and antihypertensive effects of Ligusticum wallichii ,and Angelica gigas [J]. J Ethnopharmacol , 2010 , 130 ( 3 ): 545 - 551 .
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