Investigation of Decoction Process of Digda-4 Decoction

Xiang TIAN; Rui-xue DING; Gen-na BA; Yu-xia BAI; Namujila LAXI; Da-yu CAI; Xiao-yong RAO; Xiao-jian LUO

doi:10.13422/j.cnki.syfjx.20190753

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Investigation of Decoction Process of Digda-4 Decoction

Pharmacy and Processing | 更新时间：2021-02-09

- Investigation of Decoction Process of Digda-4 Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 13, Pages: 133-139(2019)
- 作者机构：
  
  1.江西中医药大学　药学院，中药固体制剂制造技术国家工程研究中心，南昌　 330006；
  2.内蒙古民族大学　蒙医药学院，内蒙古　通辽　 028000；
  3.楚天科技股份有限公司，湖南　宁乡　 410600
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190753
  CLC： R22; R94; R28; C37; O657.7
- Received：21 October 2018，
  
  Published Online：18 December 2018，
  
  Published：05 July 2019
- 稿件说明：
移动端阅览
Xiang TIAN, Rui-xue DING, Gen-na BA, et al. Investigation of Decoction Process of Digda-4 Decoction[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(13): 133-139.
DOI：

Xiang TIAN, Rui-xue DING, Gen-na BA, et al. Investigation of Decoction Process of Digda-4 Decoction[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(13): 133-139. DOI： 10.13422/j.cnki.syfjx.20190753.

摘要

目的：

优化地格达-4味汤(DGD-4D)的煎煮工艺，为蒙药汤剂煎煮规范化研究提供参考。

方法：

以DGD-4D为模型药，比较了不同蒙药煎煮方法；采用HPLC测定汤剂中指标成分秦皮乙素、栀子苷、胡黄连苷Ⅰ和胡黄连苷Ⅱ的含量，以指标成分转移率和浸膏得率为指标，在单因素试验基础上，采用星点设计-效应面法优选DGD-4D的煎煮工艺，使用Design-Expert 8.0.6软件进行回归模型拟合，建立工艺参数预测模型，并对最优工艺进行验证。

结果：

确定DGD-4D最佳煎煮条件为加40倍量水，煎煮17 min，煎煮1次；秦皮乙素、栀子苷、胡黄连苷Ⅰ和胡黄连苷Ⅱ转移率以及浸膏得率分别为70.01%，94.11%，61.23%，92.32%，32.89%。

结论：

建立了DGD-4D的最佳煎煮方法，对于提高蒙药制剂水平以及保证其临床疗效的一致性具有重要参考意义。

Abstract

Objective:

To optimize the decoction process of Digda-4 decoction(DGD-4D)

and provide reference for the standardization study of decoction of Mongolian medicine decoction.

Method:

Taking DGD-4D as model drug

different decoction methods of Mongolian medicine were compared

HPLC was used to determine contents of aesculetin

geniposide

picroside Ⅰ and picroside Ⅱ.On the basis of single factor tests

central composite design-response surface methodology was adopted to optimize the decoction process of DGD-4D with transfer rates of 4 components and dry extract rate as indexes

regression model fitting was carried out by Design-Expert 8.0.6 software

prediction model of process parameters was established

and the optimal process was verified.

Result:

The optimal decoction condition of DGD-4D was determined to be adding 40 times the amount of water and decocting for 17 min

decocting once.Transfer rates of aesculetin

geniposide

picroside Ⅰ

picroside Ⅱ and dry extract rate were 70.01%

94.11%

61.23%

92.32%

32.89%

respectively.

Conclusion:

The optimum decoction process of DGD-4D is established

it has important reference significance for excavating

sorting

improving the level of Mongolian medicine preparations and ensuring the consistency of their clinical efficacy.

关键词

Keywords

references

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Related Institution

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