Laws of Syndrome and Prescription in Yin Deficiency Syndrome of Systemic Lupus Erythematosus Based on Complex Network Analysis

Mei-ying HE; Xin-lin CHEN; Xian-tao LI

doi:10.13422/j.cnki.syfjx.20190826

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Laws of Syndrome and Prescription in Yin Deficiency Syndrome of Systemic Lupus Erythematosus Based on Complex Network Analysis

Data Mining | 更新时间：2021-02-09

- Laws of Syndrome and Prescription in Yin Deficiency Syndrome of Systemic Lupus Erythematosus Based on Complex Network Analysis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 16, Pages: 152-160(2019)
- 作者机构：
  
  广州中医药大学　基础医学院，广州　 511400
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190826
  CLC： R22; R242; R2-031; R285.5
- Received：09 October 2018，
  
  Published Online：04 January 2019，
  
  Published：20 August 2019
- 稿件说明：
移动端阅览
Mei-ying HE, Xin-lin CHEN, Xian-tao LI. Laws of Syndrome and Prescription in Yin Deficiency Syndrome of Systemic Lupus Erythematosus Based on Complex Network Analysis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(16): 152-160.
DOI：

Mei-ying HE, Xin-lin CHEN, Xian-tao LI. Laws of Syndrome and Prescription in Yin Deficiency Syndrome of Systemic Lupus Erythematosus Based on Complex Network Analysis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(16): 152-160. DOI： 10.13422/j.cnki.syfjx.20190826.

摘要

目的：

挖掘系统性红斑狼疮(SLE)阴虚证临床核心症状及方药，为中医临床辨证及治疗SLE阴虚证提供参考。

方法：

用复杂网络分析方法，通过临床回顾在广州中医药大学第一附属医院2011年1月至2017年5月病案室322例SLE患者病历以及计算机检索筛选出的134篇中医药治疗SLE的文献，对SLE阴虚证中医临床的症状、用药进行复杂网络构建，计算网络的拓扑性质参数，分析SLE阴虚证中医临床核心症状、方药、配伍规律和组方特点。

结果：

运用复杂网络分析方法得出，本研究中治疗SLE阴虚证的核心中药主要有生地黄、牡丹皮、赤芍、知母、黄芩、青蒿清热，山萸肉收涩，秦艽祛风湿热，鳖甲、女贞子补阴，白芍补血，茯苓、泽泻、薏苡仁利水消肿，山药、甘草片补气，制半夏化痰；核心处方为青蒿鳖甲汤、六味地黄丸；核心症状有疲乏、眠差、纳差、低热、五心烦热、盗汗、头晕、皮疹、皮肤红斑、面部鲜红蝶形红斑、斑疹暗红、脱发、腰膝酸软、关节痛、肌肉痛、耳鸣、口干、咽痛、舌红、苔少、脉细数。核心症状与证候诊断标准进行比较，有新的临床常见症状出现，即眠差、纳差、面部鲜红蝶形红斑、斑疹暗红。

结论：

SLE以阴虚血热为主要病机，治疗应养阴生津、清热凉血、清虚热，本文运用复杂网络分析法对计算机文献检索及临床病历回顾性研究探讨SLE阴虚证中医临床的症方药规律得出结论与临床基本一致，可为SLE阴虚证中医临床辨证治疗作参考。

Abstract

Objective:

To explore the laws of core symptom and traditional Chinese medicine(TCM) prescription in treatment of the Yin deficiency syndrome of systemic lupus erythematosus (SLE)

in order to provide the objective basis for the treatment of SLE with TCM based on complex network.

Method:

Complex network analysis method was used to retrospectively study 322 TCM prescriptions collected from the First Affiliated Hospital of Guangzhou University of Chinese Medicine between January 2011 and May 2017 and 134 literatures about treatment of SLE with TCM through computer retrieval. The topological property parameters of the complex network were calculated

and used to analyze the structure of the core network and the compatibility rule of symptom and TCM. Then the core syndrome

herbs

compatibility rules and characteristics of commonly used prescriptions for SLE were analyzed.

Result:

The results of analysis of complex network showed that the core TCM herbs for Yin deficiency syndrome of SLE mainly included Rehmanniae Radix

Moutan Cortex

Paeoniae Radix Rubra

Anemarrhenae Rhizoma

Scutellariae Radix

Artemisiae Annuae Herba

Cornt Fructus

Gentianae Macrophyllae Radix

Trionycis Carapax

Ligustri Lucidi Fructus

Paeoniae Radix Alba

Poria

Alismatis Rhizoma

Coicis Semen

Dioscoreae Rhizoma

Glycyrrhizae Radix et Rhizoma

Pinelliae Rhizoma.Core prescriptions included Qinghao Biejia Tang and Liuwei Dihuang Wan. Core syndromes included fatigue

poor sleep

anorexia

low fever

five upset heat

night sweats

dizziness

rash

skin erythema

facial red butterfly erythema

dark red rash

alopecia

weak waist and knees

joint pain

muscle pain

tinnitus

thirst

sore throat

red tongue

tongue with less fur

and thready and rapid pulse. Compared with the diagnostic criteria of the syndrome

the core symptoms included some new common clinical symptoms

such as poor sleep

anorexia

facial red butterfly erythema

dark red rash.

Conclusion:

The main pathogenesis of SLE is Yin deficiency and blood heat

so the treatment should be nourishing Yin and generating body fluid

removing pathogenic heat from blood and clearing deficient heat. In this study

the results of clinical retrospective review and computer retrieval by the complex network analysis method were basically consistent with the clinical application. It can be used as a reference for the clinical syndrome differentiation and treatment of Yin deficiency syndrome of SLE.

关键词

Keywords

references

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