Clinical Observation of Modified Wufu Maxin Guijiang Decoction Treatment to Chronic Nonspecific Low Back Pain (NLBP) with Syndrome of Cold Dampness and Stasis

Yan CAI; Zong-bo ZHOU; Shu-hong GUI; Gui-zhu CHEN; Yu-ling LI; Jia-min ZHU

doi:10.13422/j.cnki.syfjx.20190831

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Clinical Observation of Modified Wufu Maxin Guijiang Decoction Treatment to Chronic Nonspecific Low Back Pain (NLBP) with Syndrome of Cold Dampness and Stasis

Clinic | 更新时间：2021-02-09

- Clinical Observation of Modified Wufu Maxin Guijiang Decoction Treatment to Chronic Nonspecific Low Back Pain (NLBP) with Syndrome of Cold Dampness and Stasis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 7, Pages: 128-133(2019)
- 作者机构：
  
  1.海南省人民医院，海口　 570000；
  2.海口市中医医院，海口　 570216
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190831
  CLC： R289;R274;R274.3;R245
- Received：11 September 2018，
  
  Published Online：17 December 2018，
  
  Published：05 April 2019
- 稿件说明：
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Yan CAI, Zong-bo ZHOU, Shu-hong GUI, et al. Clinical Observation of Modified Wufu Maxin Guijiang Decoction Treatment to Chronic Nonspecific Low Back Pain (NLBP) with Syndrome of Cold Dampness and Stasis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(7): 128-133.
DOI：

Yan CAI, Zong-bo ZHOU, Shu-hong GUI, et al. Clinical Observation of Modified Wufu Maxin Guijiang Decoction Treatment to Chronic Nonspecific Low Back Pain (NLBP) with Syndrome of Cold Dampness and Stasis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(7): 128-133. DOI： 10.13422/j.cnki.syfjx.20190831.

摘要

目的：

观察加味乌附麻辛桂姜汤治疗慢性非特异性下腰痛(NLBP)寒湿瘀阻证的近期和远期疗效及作用机制。

方法：

将119例符合要求患者按随机数字表分为对照组和观察组。对照组59例采用针刺＋普拉提运动。观察组60例在对照组治疗的基础上服用加味乌附麻辛桂姜汤，1剂/d。两组疗程均为连续治疗6周。进行治疗前后简化McGill疼痛量表(SF-MPQ)[包括疼痛分级指数(PRI)，疼痛视觉模拟评分(VAS)和现在疼痛状况(PPI)]，Oswestry功能障碍指数(ODI)，日本骨科协会下腰痛量表(JOA)和寒湿瘀阻证评分，治疗后患者行自我疗效评估；检测治疗前后肿瘤坏死因子-

(TNF-

)，血栓素2(TXB

)，6-酮-前列腺素F

(6-Keto-PGF

)和白细胞介素-1

(IL-1

)水平。

结果：

经秩和检验，治疗后观察组临床疗效优于对照组（

＝2.226，

0.05），自我疗效评估也优于对照组（

＝2.104，

0.05）；治疗后观察组SF-MPQ量表PRI，VAS和PPI评分均低于对照组（

0.01）；观察组患者JOA量表评分高于对照组（

0.01），寒湿瘀阻证评分和ODI量表评分均低于对照组（

0.01）；观察组患者TNF-

，IL-1

，TXB

水平均低于对照组（

0.01），6-Keto-PGF

高于对照组（

0.01），TXB

/6-Keto-PGF

低于对照组（

0.01）。

结论：

在针刺和运动疗法的基础上，采用加味乌附麻辛桂姜汤治疗慢性NLBP，近期能改善疼痛等症状，促进患者功能恢复，提高日常生活能力，远期能稳定病情，减少复发，并具有一定抗炎、镇痛作用。

Abstract

Objective:

To observe the short-term and long-term clinical effect of modified Wufu Maxin Guijiang decoction treatment to chronic nonspecific low back pain (NLBP) with syndrome of cold dampness and stasis

and to investigate the mechanism of anti-inflammatory and analgesia.

Method:

One hundred and nineteen eligible patients were randomly divided into control group (59 cases) and observation group (60 cases) by random number table. Patients in control group got acupuncture treatment and pilates. Based on the treatment in control group

patients in observation received additional modified Wufu Maxin Guijiang decoction

1 dose/day. The course of treatment was 6 weeks in both groups. Before and after treatment

scores of short-form McGill pain questionnaire (SF-MPQ)

Oswestry disability index (ODI)

Japanese orthopaedic association (JOA) and syndrome of cold dampness were graded. After treatment

the patients made self efficacy assessment. Levels of thromboxane 2 (TXB

)

6-Keto-PGF

tumor necrosis factor-

(TNF-

) and interleukins-1

(IL-1

) were detected both before and after treatment.

Result:

After treatment

the rank sum test showed that the clinical efficacy in observation group was better than that in control group (

=2.226

0.05)

and the self efficacy assessment showed the efficacy in observation group was also better than that in control group(

=2.104

0.05). Scores of SF-MPQ

PRI

VAS

PPI

ODI and syndrome of cold dampness and stasis in observation group were all lower than those in control group (

0.01)

and score of JOA was higher than that in control group (

0.01). Levels of TXB

TNF-

and IL-1

and TXB

/6-Keto-PGF

were lower than those in control group (

0.01)

and the level of 6-Keto-PGF

was higher than that in control group (

0.01).

Conclusion:

Based on the acupuncture treatment and pilates

modified Wufu Maxin Guijiang decoction in the treatment of chronic NLBP can ameliorate symptoms of pain

promote the recovery of function

and enhance activity of daily living in a short term

reduce the recurrence and stabilize the disease condition in a long term

with certain effects of anti-inflammatory and analgesia.

关键词

Keywords

references

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