Clinical Observation of Jiawei Bushen Huoxuetang Combined with Fumigation of Traditional Chinese Medicine After Operation of Vertebral Compression Fracture

Hai-ling ZHAO; Zong-bo ZHOU; Jian-qiang LI; Jian HUANG; Yi CHENG; Zhi-fu LU

doi:10.13422/j.cnki.syfjx.20190832

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Clinical Observation of Jiawei Bushen Huoxuetang Combined with Fumigation of Traditional Chinese Medicine After Operation of Vertebral Compression Fracture

Clinic | 更新时间：2021-02-09

- Clinical Observation of Jiawei Bushen Huoxuetang Combined with Fumigation of Traditional Chinese Medicine After Operation of Vertebral Compression Fracture
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 8, Pages: 95-100(2019)
- 作者机构：
  
  海口市中医医院，海口　 570216
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190832
  CLC： R289;R68;R683;R683.2
- Received：29 September 2018，
  
  Published：20 April 2019
- 稿件说明：
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Hai-ling ZHAO, Zong-bo ZHOU, Jian-qiang LI, et al. Clinical Observation of Jiawei Bushen Huoxuetang Combined with Fumigation of Traditional Chinese Medicine After Operation of Vertebral Compression Fracture[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 95-100.
DOI：

Hai-ling ZHAO, Zong-bo ZHOU, Jian-qiang LI, et al. Clinical Observation of Jiawei Bushen Huoxuetang Combined with Fumigation of Traditional Chinese Medicine After Operation of Vertebral Compression Fracture[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 95-100. DOI： 10.13422/j.cnki.syfjx.20190832.

摘要

目的：

观察加味补肾活血汤联合中药熏蒸治疗骨质疏松性椎体压缩性骨折(OVCF)术后的疗效及对骨密度和骨代谢的影响。

方法：

将116例OVCF术后患者按随机数字表法分为对照组和观察组各58例。对照组口服阿仑膦酸钠片

70 mg/次

1次/周；四烯甲萘醌软胶囊

15 mg/次

3次/d，饭后服用；碳酸钙D

咀嚼片(Ⅱ)

1片/次

2次/d；观察组在对照组治疗的基础上给予加味补肾活血汤内服

1剂/d；两组患者均连续治疗24周。在服用中药的同时联合中药熏蒸治疗2周。采用疼痛视觉模拟评分法(VAS)评价腰背疼程度，采用Oswestry 功能障碍指数(ODI)评价腰部功能障碍程度，分别于术后4

12和24周进行评价；评价治疗前后椎体前壁高度(AVBH)，椎体后凸角度(Cobb)，股骨颈和腰椎骨密度及中国人骨质疏松症生存质量简明量表(COQOL)；检测治疗前后Ⅰ型胶原羧基端前肽(CICP)，I型胶原羧基端交联肽(CTX-I)，抗酒石酸酸性磷酸酶(TRACP)，骨碱性磷酸酶(BALP)，骨钙素(BGP)水平。

结果：

经秩和检验，观察组临床疗效优于对照组(

=2.026，

0.05)；观察组治疗术后4

12和24周腰背疼痛VAS评分和ODI评分均低于对照组(

0.01)；观察组的AVBH，股骨颈骨密度和腰椎骨密度高于对照组(

0.01)

Cobb角小于对照组；观察组患者COQOL量

表4

个维度评分均低于对照组(

0.01)；观察组患者BALP

CICP

CTX-I和TRACP水平均低于对照组(

0.01)

BGP水平高于对照组(

0.01)。

结论：

加味补肾活血方联合中药熏蒸治疗OVCF术后患者，可增强骨密度，调节骨代谢，减轻腰背疼痛，促进了骨折的愈合，改善骨质疏松，临床疗效显著。

Abstract

Objective:

To observe the effect of Jiawei Bushen Huoxuetang on osteoporotic vertebral compression fractures (OVCF)

bone density and bone metabolism.

Method:

One hundred and sixteen patients with OVCF operation were randomly divided into control group (58 cases) and observation group (58 cases) by random number table. Patients in control group got Alendronate sodium tablets

70 mg/time

1 time/week. Menatetrenone soft capsules

15 mg/time

3 times/days after meals. Calcium carbonate D

chewable tablets (Ⅱ)

1 tablet/time

2 times/days. Based on the treatment in control group

patients in observation group received additional Jiawei Bushen Huoxue decoction

1 dose/day. The course of treatment was 24 weeks in both groups. The treatment of traditional Chinese medicine(TCM) fumigation was used in combination with the TCM for 2 weeks. At the 4

and 24

weeks after treatment

pain degree of waist and back were evaluated by pain visual analogue scale (VAS)

and waist dysfunction was evaluated by Oswestry disability index (ODI). Before and after treatment

anterior vertebral height (AVBH)

Cobb

femoral neck

lumbar spine bone mineral density and Chinese osteoporosis quality of life scale were evaluated. Before and after treatment

levels of carboxy terminal propeptide of type I collagen (CICP)

C-terminal cross-linking peptide of type I collagen (CTX-I)

tartrate resistant acid phosphatase (TRACP)

bone alkaline phosphatase (BALP) and bone glaprotein(BGP) were detected.

Result:

By rank sum test

the clinical efficacy in observation was better than that in control group (

=2.026

0.05). At the 4

and 24

weeks after treatment

scores of lumbago and back pain VAS and ODI were lower than those in control group (

0.01). AVBH

femoral neck bone mineral density

and lumbar spine bone mineral density in observation group were higher than those in control group (

0.01). Cobb angle was smaller than that in control group; and the four dimension scores of COQOL were lower than those in control group (

0.01). Levels of BALP

CICP

CTX-I and TRACP in observation group were lower than those in control group (

0.01)

and BGP was higher than that in control group (

0.01).

Conclusion:

Jiawei Bushen Huoxuetang can enhance bone mineral density

regulate bone metabolism

reduce back pain

promote healing of fracture

and ameliorate osteoporosis

with obvious clinical efficacy.

关键词

Keywords

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