Effect of Whenshen Prescription on Hepatic Encephalopathy in Patients with HBV-related Hepatic Cirrhosis and Content of HMGB<sub>1</sub>/TLR4

Jian-xing LUO; Xiao-yu HU

doi:10.13422/j.cnki.syfjx.20190926

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Effect of Whenshen Prescription on Hepatic Encephalopathy in Patients with HBV-related Hepatic Cirrhosis and Content of HMGB₁/TLR4

Clinic | 更新时间：2021-02-09

- Effect of Whenshen Prescription on Hepatic Encephalopathy in Patients with HBV-related Hepatic Cirrhosis and Content of HMGB₁/TLR4
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 15, Pages: 131-135(2019)
- 作者机构：
  
  成都中医药大学　附属医院，成都　 610072
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190926
  CLC： R22; R242; R2-031; R287
- Received：30 October 2018，
  
  Published Online：17 January 2019，
  
  Published：05 August 2019
- 稿件说明：
移动端阅览
Jian-xing LUO, Xiao-yu HU. Effect of Whenshen Prescription on Hepatic Encephalopathy in Patients with HBV-related Hepatic Cirrhosis and Content of HMGB₁/TLR4[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(15): 131-135.
DOI：

Jian-xing LUO, Xiao-yu HU. Effect of Whenshen Prescription on Hepatic Encephalopathy in Patients with HBV-related Hepatic Cirrhosis and Content of HMGB₁/TLR4[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(15): 131-135. DOI： 10.13422/j.cnki.syfjx.20190926.

摘要

目的：

观察温肾方治疗乙肝肝硬化合并肝性脑病肾阳虚证患者的临床疗效及其对高迁移率族蛋白B

(high mobility group protein B

，HMGB

)，Toll样受体4(Toll-like receptor 4，TLR4)含量的影响。

方法：

纳入成都中医药大学附属医院2013年8月至2015年1月收治的66例乙肝肝硬化合并肝性脑病患者。采用前瞻性、平行对照方法设计，将纳入的66例患者按1∶1分为治疗组和对照组，每组各33例。对照组给予常规内科综合治疗、结肠透析和安慰剂灌肠。治疗组给予常规内科综合治疗、结肠透析和温肾方灌肠。疗程均为10日。治疗前后分别检测患者肝功能水平、数字连接试验(number connect test

NCT)时间、数字符号试验(digit-symbol test，DST)评分及血氨水平，外周血HMGB

，TLR4含量。治疗结束后，分别计算两组患者清醒时间及总有效率。

结果：

两组患者基线具有可比性。治疗结束后，治疗组总有效率优于对照组(

0.05)。治疗组在血氨下降幅度，肝功能恢复程度，NCT时间下降幅度，SDT评分增加程度以及患者清醒时间缩短幅度等方面均优于对照组(

0.05)。治疗结束后，治疗组外周血HMGB

，TLR4含量低于对照组(

0.05)。

结论：

温肾方可显著提高乙肝肝硬化合并肝性脑病肾阳虚证患者的临床疗效，其作用机制可能与抑制HMGB

，TLR4含量，进而抑制炎症因子释放，降低血氨水平有关。

Abstract

Objective:

To investigate the effect of Whenshen prescription on hepatic encephalopathy in patients with HBV-related hepatic cirrhosis and kidney Yang deficiency syndrome and the content of high-mobility group protein B

(HMGB

) and Toll-like receptor 4 (TLR4).

Method:

The 66 patients treated in the Hospital of Chengdu University of Traditional Chinese Medicine from August 2013 to January 2015 were included. A prospective

parallel controlled design was used. The 66 cases were randomly divided into treatment group and control group according to 1∶1 ratio

with 33 cases in each group.The control group was treated with comprehensive therapy

colon dialysis and placebo enema

while treatment group was treated with comprehensive therapy

colon dialysis and Whenshen prescription enema for 10 days. Finally

liver function

number connect test (NCT)

digit-symbol test (SDT)

awake time

the total effective rate and content of HMGB

and TLR4 were analyzed.

Result:

There was no significant difference between two groups at baseline. The total effective rate in treatment group was 93.9%

which was higher than 72.7% in control group (

0.05). Plasma ammonia

liver function

awake time

NCT and SDT in treatment group were better than those in control group (

0.05). The contents of HMGB

and TLR4 in treatment group were lower than those in the control group.

Conclusion:

Whenshen prescription can significantly improve the clinical efficacy by inhibiting the contents of HMGB

and TLR4.

关键词

Keywords

references

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Effect of Whenshen Prescription on Hepatic Encephalopathy in Patients with HBV-related Hepatic Cirrhosis and Content of HMGB1/TLR4

DOI：10.13422/j.cnki.syfjx.20190926

摘要

Abstract

关键词

Keywords

references

Effect of Whenshen Prescription on Hepatic Encephalopathy in Patients with HBV-related Hepatic Cirrhosis and Content of HMGB₁/TLR4