Clinical Effect of Peiyuan Tongnao Capsule Combined with " Zhisanzhen" for Post-stroke Dementia

Cui-lei JIANG; Jun-jie ZHAO; Fei LOU; Ying ZHOU

doi:10.13422/j.cnki.syfjx.20190931

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Clinical Effect of Peiyuan Tongnao Capsule Combined with " Zhisanzhen" for Post-stroke Dementia

Clinic | 更新时间：2021-02-09

- Clinical Effect of Peiyuan Tongnao Capsule Combined with " Zhisanzhen" for Post-stroke Dementia
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 9, Pages: 103-108(2019)
- 作者机构：
  
  泰山医学院　附属莱芜医院，山东　莱芜　 271100
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20190931
  CLC： R25; R255; R256; R245
- Received：25 September 2018，
  
  Published Online：28 December 2018，
  
  Published：05 May 2019
- 稿件说明：
移动端阅览
Cui-lei JIANG, Jun-jie ZHAO, Fei LOU, et al. Clinical Effect of Peiyuan Tongnao Capsule Combined with " Zhisanzhen" for Post-stroke Dementia[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(9): 103-108.
DOI：

Cui-lei JIANG, Jun-jie ZHAO, Fei LOU, et al. Clinical Effect of Peiyuan Tongnao Capsule Combined with " Zhisanzhen" for Post-stroke Dementia[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(9): 103-108. DOI： 10.13422/j.cnki.syfjx.20190931.

摘要

目的：

观察培元通脑胶囊联合“智三针”治疗卒中后痴呆(PSD)的临床疗效及作用机制。

方法：

采用SAS软件生成随机数字表法将98例符合要求的患者分为对照组和观察组各49例。两组患者基础治疗口服多奈哌齐片，10 mg／次，1次/d；尼莫地平片，30 mg／次，1次/d，口服。对照组采用“智三针”，1次/d，5次／周。观察组针刺同对照组，加服培元通脑胶囊，3粒／次，3次/d。两组疗程均为连续治疗12周。于治疗前、治疗后4，8，12周评价简易精神状态(MMSE)和蒙特利尔认知评估量表(MoCA)，评估治疗前后日常生活能力量表(ADL)，神经精神症状问卷(NPI)和中医证候，检测治疗前后血清同型半胱氨酸(Hcy)，肝细胞生长因子(HGF)，氧化低密度脂蛋白(Ox-LDL)和乙酰胆碱酶(AchE)水平。

结果：

观察组临床疗效总有效率为93.88%，高于对照组的77.55%(

＝5.333，

0.05)；经重复测量的方差分析，治疗后两组患者MoCA评分逐渐升高(

对照

＝3.947，

观察

＝5.833，

0.05)；MMSE评分也逐渐升高(

对照

＝3.876，

观察

＝6.011，

0.05)，；观察组患者在治疗后8周和12周MMSE评分均高于对照组(

0.05)，12周观察组MoCA评分高于对照组(

0.05)；治疗后观察组MMSE量表的定向力、注意力和计算力、语言3个因子评分均高于对照组(

0.05)；观察组患者的MMSE和MoCA评分治疗前后差值均高于对照组(

0.05)；治疗后观察组患者ADL

NPI-1，NPI-2和中医证候评分均低于对照组(

0.01)；观察组患者Hcy

Ox-LDL和AchE水平均低于对照组，HGF水平高于对照组(

0.01)。

结论：

培元通脑胶囊内服联合“智三针”治疗PSD能进一步的提高认知能力和行为能力，改善精神行为异常，减轻临床症状，提高临床疗效，并能调节Hcy

Ox-LDL

AchE和HGF水平。

Abstract

Objective:

To observe the clinical efficacy of Peiyuan Tongnao capsule combined with " Zhisanzhen" for post-stroke dementia (PSD) and investigate its mechanism.

Method:

Ninety-eight eligible patients were randomly divided into control group (49 cases) and observation group (49 cases) by random number table. Both groups received donepezil tablet

10 mg/time

and nimodipine tablet

30 mg/time

. Patients in control group additionally took " Zhisanzhen"

5 times/week. Based on the treatment in control group

patients in observation group additionally took Peiyuan Tongnao capsule

3 capsules/time

tid

. The treatment course was 12 weeks. Before and at the 4

and 12

week after treatment

mini-mental state examination (MMSE)

montreal cognitive assessment (MoCA)

activity of daily living scale (ADL)

neuropsychiatric inventory (NPI) and symptoms of traditional Chinese medicine(TCM)were evaluated. Before and after treatment

levels of serum hyperhomocysteinemia (Hcy)

hepatocyte growth factor (HGF)

oxidized low density lipoprotein (Ox-LDL) and acetylcholinesterase (AchE) were detected.

Result:

The total clinical effective rate was 93.88% in observation group

better than 77.55% in control group (

=5.333

0.05). Repeat measurement ANOVA after treatment showed that scores of MoCA

MMSE were gradually increased (

control

=3.947

observation

=5.833

0.05 for MoCA.

control

=3.876

observation

=6.011

0.05 for MMSE). At the 8

and 12

after treatment

scores of MMSE in the observation group were all higher than those in control group (

0.05). At the 12

week after treatment

score of MoCA in observation group was higher than that in control group (

0.05). Scores of directing force

attention

capacity of calculation in observation group were higher than those in control group after treatment (

0.05). The changes in scores of MMSE and MoCA in observation group were larger than those in control group after treatment (

0.05). Scores of ADL

NPI-1

NPI-2 and symptom of TCM in observation group were lower than those in control group (

0.01). Levels of Hcy

Ox-LDL and AchE were also lower than those in control group

while level of HGF was higher than that in control group (

0.01).

Conclusion:

Peiyuan Tongnao capsule combined with " Zhisanzhen" can improve cognitive and behavioral abilities

improve clinical efficacy

ameliorate abnormal mental behavior

relieve clinical symptoms

and regulate levels of Hcy

Ox-LDL

AchE and HGF in the treatment of post-stroke dementia.

关键词

Keywords

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