Clinical Efficacy and Serum Metabonomics of Duhuo Xuduan Tang in Treating Lumbar Disc Herniation Due to Liver and Kidney Yin Deficiency

Sheng LIU; Ling LIU; Zhi-guang WANG; Wei FANG

doi:10.13422/j.cnki.syfjx.20191125

您当前的位置：

首页 >

文章列表页 >

Clinical Efficacy and Serum Metabonomics of Duhuo Xuduan Tang in Treating Lumbar Disc Herniation Due to Liver and Kidney Yin Deficiency

Clinic | 更新时间：2021-02-09

- Clinical Efficacy and Serum Metabonomics of Duhuo Xuduan Tang in Treating Lumbar Disc Herniation Due to Liver and Kidney Yin Deficiency
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 11, Pages: 91-96(2019)
- 作者机构：
  
  1.天津中医药大学　第一附属医院，天津　 300193；
  2.天津市第四中心医院，天津　 300143
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191125
  CLC： R22; R242; R2-031; R287
- Received：16 October 2018，
  
  Published Online：19 February 2019，
  
  Published：05 June 2019
- 稿件说明：
移动端阅览
Sheng LIU, Ling LIU, Zhi-guang WANG, et al. Clinical Efficacy and Serum Metabonomics of Duhuo Xuduan Tang in Treating Lumbar Disc Herniation Due to Liver and Kidney Yin Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(11): 91-96.
DOI：

Sheng LIU, Ling LIU, Zhi-guang WANG, et al. Clinical Efficacy and Serum Metabonomics of Duhuo Xuduan Tang in Treating Lumbar Disc Herniation Due to Liver and Kidney Yin Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(11): 91-96. DOI： 10.13422/j.cnki.syfjx.20191125.

摘要

目的：

观察独活续断汤对肝肾阴虚型腰间盘突出症患者疗效，探讨血清中代谢组学的变化。

方法：

将2017年1月至2018年9月天津中医药大学第一附属医院收治的非急症期腰间盘突出症患者68例随机分为观察组(38例)和对照组(30例)，入组患者均给予复位手法治疗后绝对卧床休息，观察组给予独活续断汤治疗，150 mL/次，2次/d，口服，对照组给予布洛芬300 mg/次，维生素B

10 mg/次，2次/d，口服，每周连续服药5 d，停药2 d，两组患者均连续治疗4周；观察两组患者治疗前后视觉模拟评分(VAS)，日本骨科协会评估治疗(JOA)分数及临床疗效；采用超高液相色谱-质谱联用技术比较治疗前后两组患者血清代谢组学变化。

结果：

与本组治疗前比较，两组患者VAS评分降低，JOA评分升高(

0.01)；与对照组治疗后比较，观察组临床疗效明显提高(

0.01)，且患者VAS评分降低，JOA评分升高(

0.01)，血清中柠檬酸、赖氨酸、丙酮酸及

-隐黄素含量均升高(

0.01)。

结论：

独活续断汤治疗肝肾阴虚型腰间盘突出症有明确疗效，其机制可能与增强患者能量代谢及抗氧化、抗炎有关。

Abstract

Objective:

To observe the efficacy of Duhuo Xuduan Tang in treating patients with liver and kidney Yin-deficiency type of lumbar disc herniation

and explore the changes of metabolomics in serum.

Method:

Totally 68 cases of non-emergency lumbar disc herniation admitted to the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from January 2017 to September 2018 were randomly divided into observation group (38 cases) and routine group (30 cases). All of patients in both groups rest in bed after reduction maneuver. The observation group was orally treated with Duhuo Xuduan Tang

150 mL/time

2 times/d

and the control group was orally given ibuprofen

300 mg/time

and vitamin B

10 mg/time

2 times/d. The drugs were administered for 5 days a week and then stopped for 2 days. Both groups were treated continuously for 4 weeks. Before and after treatment

the visual analogue scale (VAS)

the Japanese Orthopaedic Association assessment treatment (JOA) score and the clinical efficacy were observed. The serum metabolomics changes of two groups before and after treatment were compared by ultra-high liquid chromatography-mass spectrometry.

Result:

Compared with before treatment

the VAS scores of two groups were lower

while the JOA scores were increased (

0.01). Compared with the routine group after treatment

the clinical efficacy of observation group was significantly improved (

0.01)

and the VAS score decreased and the JOA score increased (

0.01). The contents of citric acid

lysine

pyruvic acid and

-cryptoxanthin in serum were increased (

0.01).

Conclusion:

Duhuo Xuduan Tang has a clear curative effect in treating lumbar disc herniation with liver and kidney Yin deficiency. The mechanism may be related to the enhancement of energy metabolism

anti-oxidation and anti-inflammation.

关键词

Keywords

references

曾佳兴，梁斌，尹东，等．青少年与中老年腰椎间盘突出相关因素分析 [J]．中国矫形外科杂志， 2013 ， 21 ( 11 )： 1121 - 1126 ．

李星凤，熊钰，邓诗佳，等．腰椎间盘突出症患者疼痛信念与生活质量的相关性分析 [J]．护理学杂志， 2016 ， 31 ( 2 )： 51 - 53 ．

宋芳娇，曾克武，王学美．中药复方有效成分组相关研究方法的研究进展 [J]．环球中医药， 2012 ， 5 ( 12 )： 951 - 955 ．

李医明．从“中药化学”到“化学中药”——对中药化学学科发展的一点臆想 [J]．上海中医药大学学报， 2018 ， 32 ( 4 )： 1 - 3 ．

陈佳佳，李爱平，张晓琴，等．基于核磁共振代谢组学的成分数据分析在中药评价中的应用 [J]．中草药， 2016 ， 47 ( 19 )： 3522 - 3526 ．

贾孟琪，薛芸，王彦，等．色谱-质谱联用技术在中药代谢组学研究中的应用 [J]．分析测试学报， 2016 ， 35 ( 2 )： 172 - 178 ．

Everett J R . A new paradigm for known metabolite identification in Metabonomics/metabolomics: metabolite identification efficiency [J]. Comput Struct Biotechnol J , 2015 , 13 ( 2 ): 131 - 144 .

荣兵，李建，贾峻，等．独活寄生汤治疗肝肾亏虚型膝骨关节炎患者临床疗效及关节液代谢组学变化 [J]．中国实验方剂学杂志， 2017 ， 23 ( 23 )： 159 - 165 ．

王志光，商艳慧，谭涛，等．独活续断汤对不同类型腰间盘突出症患者临床疗效、生活能力的影响及机制 [J]．中国实验方剂学杂志， 2019 ， 25 ( 4 )： 63 - 69 ．

中华医学会．临床诊疗指南·骨科分册 [M]．北京：人民卫生出版社， 2009 ： 97 - 98 ．

国家中医药管理局．中医病证诊断疗效标准 [M]．北京：中国中医药出版社， 2014 ： 214 ．

张斌．右归丸治疗腰间盘突出症随机平行对照研究 [J]．光明中医， 2017 ， 32 ( 6 )： 775 - 777 ．

Michael E , Swart Z . Ultra performance liquid chromatography(UPLC): an introduction [J]. Sep Sci Red , 2005 , 5 ( 40 ): 8 - 14 .

李佩，曾祥英，崔君涛，等．液相色谱-串联质谱法测定尿液中7种有机磷酸酯代谢物 [J]．分析化学， 2017 ， 45 ( 11 )： 1648 - 1654 ．

朱钦士．正转和反转的三羧酸循环 [J]．生物学通报， 2015 ， 50 ( 1 )： 16 - 19 ．

Haas R , Cucchi D , Smith J , et al . Intermediates of metabolism: from bystanders to signalling molecules [J]. Trends Biochem Sci , 2016 , 41 ( 5 ): 460 - 471 .

CHEN X , Schreiber K , Appel J , et al . The Entner-Doudoroff pathway is an overlooked glycolytic route in cyanobacteria and plants [J]. Proc Natl Acad Sci USA , 2016 , 113 ( 19 ): 5441 - 5446 .

刘奇，杜萍，施晓兰，等．针刺对SAMP8小鼠海马乳酸、葡萄糖、丙酮酸含量的影响 [J]．成都中医药大学学报， 2018 ， 41 ( 3 )： 9 - 13 ．

干懿洁，丁树哲．丙酮酸的抗氧化作用 [J]．中国临床康复， 2006 ， 10 ( 8 )： 141 - 143 ．

魏芹，金虹，任晓妹，等．羧甲基赖氨酸对人外周血单核细胞破骨样转化的影响 [J]．东南大学学报：医学版， 2014 ， 33 ( 3 )： 283 - 287 ．

盛冉，孙志高，黄巧娟，等． β-隐黄素的生理活性及其机理研究进展 [J]．食品与机械， 2016 ， 32 ( 12 )： 218 - 223 ．

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Mechanism Analysis of Lung Injury Induced by Water Elution Section of Siegesbeckiae Herba on Rats by ¹H-NMR Metabolomics

Investigation of Relationship Between Spleen and Alzheimer' s Disease Based on Glucose, Lipid and Energy Metabolisms

Analysis of Mechanism of Artesunate in Treatment of Liver Cancer Based on Metabolomics

Analysis of Mechanism of Xiaoyaowan on Rats with Nonalcoholic Fatty Liver Disease and Syndrome of Liver Depression and Spleen Deficiency by H-NMR Metabolomics

Establishment and Evaluation of Rat Model of Myocardial Ischemia-reperfusion Injury with Phlegm and Blood Stasis Blocking Collaterals Syndrome Based on Metabolomics

Related Author

Jie LI

Qing FAN

Jian-hong GUAN

Qin ZHENG

Jun LUO

De-lin ZHANG

Yu TANG

Mei-fang ZHU

Related Institution

Shanxi University of Chinese Medicine

State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Key Laboratory of Modern Chinese Medicine Preparations, Ministry of Education, Jiangxi University of Traditional Chinese Medicine

School of Life Science and Technology, Dalian University

Scientific Research Center for Translational Medicine, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences

Guangdong Provincial Engineering Laboratory of Chinese Medicine Preparation Technology, Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰