Effect of Yiqi Huoxue Tongmai Method in Treating Atherosclerotic Lesions of Lower Extremity of Diabetes

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Effect of Yiqi Huoxue Tongmai Method in Treating Atherosclerotic Lesions of Lower Extremity of Diabetes

Clinic | 更新时间：2021-02-09

- Effect of Yiqi Huoxue Tongmai Method in Treating Atherosclerotic Lesions of Lower Extremity of Diabetes
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 11, Pages: 103-108(2019)
- 作者机构：
  
  河南省中医院，郑州　 450002
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191131
  CLC： R25; R58; R587; R587.1
- Received：17 October 2018，
  
  Published Online：21 January 2019，
  
  Published：05 June 2019
- 稿件说明：
移动端阅览
Yan CHEN, Qing BAI, Xin-yu SUN. Effect of Yiqi Huoxue Tongmai Method in Treating Atherosclerotic Lesions of Lower Extremity of Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(11): 103-108.
DOI：

Yan CHEN, Qing BAI, Xin-yu SUN. Effect of Yiqi Huoxue Tongmai Method in Treating Atherosclerotic Lesions of Lower Extremity of Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(11): 103-108. DOI： 10.13422/j.cnki.syfjx.20191131.

摘要

目的：

2

观察益气活血通脉法治疗糖尿病下肢动脉粥样硬化性病变(LEAD)的疗效及对血流动力学指标和血管内皮功能的影响。

方法：

2

将符合要求的105例患者按随机数字表法分为对照组52例和观察组53例。对照组口服拜阿司匹林肠溶片，100 mg·d

－1

，1次/d，和西洛他唑片，100 mg·d

－1

，2次/d。观察组在对照组治疗的基础上给予当归四逆汤合补阳还五汤加减内服、外洗，1剂/d。两组均连续治疗12周。测量治疗前后踝肱指数(ABI)；采用彩色多普勒超声诊断仪检测治疗前后下肢股浅、胫后及足背动脉的内膜厚度、硬化程度、斑块大小、狭窄程度；进行治疗前后气虚血瘀证评分；检测治疗前后全血黏度，血浆黏度，血沉(ESR)，

D

-二聚体(D-D)，纤维蛋白原(FIB)和红细胞电泳水平；检测治疗前后空腹血糖(FPG)，糖化血红蛋白(HbA1c)，血清25-羟维生素D

3

[25(OH)D

3

]，内皮素(ET)，一氧化氮(NO)及同型半胱氨酸(Hcy)水平。

结果：

2

经秩和检验，观察组中医证候疗效优于对照组(

Z

＝2.371，

P

<

0.05)；治疗后观察组患者的ABI高于对照组(

P

<

0.01)，气虚血瘀证评分低于对照组(

P

<

0.01)；治疗后观察组患者双下肢股浅、胫后及足背动脉的内膜厚度、硬化程度、斑块大小、狭窄程度评分及总积分均低于对照组(

P

<

0.01)；治疗后观察组患者的全血黏度、血浆黏度，ESR，D-D，FIB和红细胞电泳时间等改善均优于对照组(

P

<

0.01)；治疗后观察组患者的HbA1c，ET和Hcy水平均低于对照组(

P

<

0.01)，25(OH)D

3

和NO水平均高于对照组(

P

<

0.01)。

结论：

2

当归四逆汤合补阳还五汤加减内服、外洗治疗糖尿病LEAD，可改善血流动力学和血管内皮功能，提高ABI，减轻动脉硬程度和狭窄程度，改善了临床症状。

Abstract

Objective:

2

To observe the effect of Yiqi Huoxue Tongmai method in treating lower extremity atherosclerotic disease (LEAD) and on hemodynamic index and vascular endothelial function.

Method:

2

One hundred and five patients were randomly divided into control group (52 cases) and observation group (53 cases) by random number table. Patients in control group were treated for controlling blood sugar

blood fat

blood pressure and given aspirin enteric-coated tablets

100 mg/day

cilostazol tablets

100 mg/day

2 times/day. In addition to the therapy of control group

patients in observation group were given modified Danggui Sini Tang and Buyang Huanwu Tang for oral and washout

1 dose/day. The treatment course lasted for 12 weeks. Before and after treatment

ankle brachial index (ABI) was detected. And intimal thickness of shallow femoral shallower

arteriae tibialis posterior and arteriae dorsalis pedis

hardening degree

patch size and degree of stenosis were detected by color Doppler ultrasound diagnostic apparatus. Qi deficiency and blood stasis syndrome were scored. And levels of the whole blood viscosity

plasma viscosity

erythrocyte sedimentation rate (ESR)

D

-dimer (D-D)

fibrinogen (FIB)

erythrocyte electrophoresis

fasting blood glucose (FPG)

glycosylated hemoglobin (HbA1c)

serum 25-hydroxyvitamin D

3

( [25(OH)D

3

] )

endothelin (ET)

nitric oxide (NO) and homocysteine (Hcy) were detected.

Result:

2

By the rank sum test

the clinical effect in observation group was better than that in control group (

Z

=2.371

P

<

0.05). After treatment

ABI in observation group was higher than that in control group (

P

<

0.01)

scores of Qi deficiency and blood stasis were lower than those in control group (

P

<

0.01). Scores of intimal thickness of shallow femoral shallower

arteriae tibialis posterior and arteriae dorsalis pedis

hardening degree

patch size and degree of stenosis and the total score in observation group were lower than those in control group (

P

<

0.01). And levels of the whole blood viscosity

ESR

D-D

FIB

erythrocyte electrophoresis were better than those in control group (

P

<

0.01)

while levels of HbA1c

ET and Hcy were lower than those in control group (

P

<

0.01)

and levels of [25(OH)D

3

] and NO were higher than those in control group (

P

<

0.01).

Conclusion:

2

Modified Danggui Sini Tang and Buyang Huanwu Tang can ameliorate hemodynamics and vascular endothelial function

improve ABI

relieve arteriosclerosis and narrow degrees

and alleviate clinical symptoms.

关键词

Keywords

references

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